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Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules

N/A

Waitlist Available

Led By Manjiri K. Dighe, MD

Research Sponsored by University of Washington

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 months. a one-time swus elastography will be performed on day 1 within 2 months prior to the patients scheduled clinical fna or surgery.

Awards & highlights

No Placebo-Only Group

Summary

Shear wave ultrasound elastography is a new technique of finding the softness or hardness in tissue by applying a "push" generated by the machine. This technique will help in diagnosing malignancy in the thyroid gland without biopsy and avoiding biopsy in noncancerous nodules.

Eligible Conditions

Thyroid Nodule

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 months. a one-time swus elastography will be performed on day 1 within 2 months prior to the patients scheduled clinical fna or surgery.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 months. a one-time swus elastography will be performed on day 1 within 2 months prior to the patients scheduled clinical fna or surgery.

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 months. a one-time swus elastography will be performed on day 1 within 2 months prior to the patients scheduled clinical fna or surgery. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Correlating stiffness from the SWUS elastography with indentometer and pathology findings

Secondary study objectives

Correlating SWUS findings with routine US findings

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: SWUS ElastographyExperimental Treatment1 Intervention

This is a noninvasive technique using focused ultrasonic beams (pushing beams.) Several pushing beams at increasing depths are transmitted to generate a quasi-plane shear wave frame that propagates throughout the imaging area. After generating the shear wave, an ultrafast imaging sequence is performed to acquire successive raw radiofrequency dots at a very high frame rate (up to 20,000 per second). A tissue elasticity assessment can be derived from shear wave propagation speed. A color-coded image is displayed; softer tissue in blue and stiffer tissue in red. Quantitative information is delivered by drawing regions of interest on the thyroid and surrounding tissues which is the Elasticity Index expressed in kilo-Pascal (kPa). Due to the lack of manual compression and known value of the strength of pushing beam, SWUS gives an objective number to stiffness within the nodule.

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