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TICS: Transcranial Magnetic Stimulation for Intervening in Children With Tourette's Syndrome (CIHR) (TICS-CIHR Trial)

N/A
Waitlist Available
Led By Frank P MacMaster, PhD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 11
Awards & highlights
No Placebo-Only Group

Summary

This trial is investigating whether pairing 3 weeks of repetitive transcranial magnetic stimulation (rTMS) and hormone replacement therapy (HRT) can reduce tic severity in children and adolescents with Tourette's Syndrome (TS).

Eligible Conditions
  • Tic Disorders

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 11
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 11 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Yale Global Tic Severity Scale Total Tic score (YGTSS)
Secondary study objectives
Functional connectivity of the Supplementary Motor Area (SMA) and the dominant Primary Motor Cortex (M1)
Supplementary Motor Area (SMA) GABA concentration as measured by LCModel (Institutional Units)
Other study objectives
Yale Global Tic Severity Scale Total Tic score (YGTSS) post CBIT

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: rTMS + CBITExperimental Treatment2 Interventions
Repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)
Group II: Sham rTMS + CBITActive Control1 Intervention
Sham repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)

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Who is running the clinical trial?

University of CalgaryLead Sponsor
810 Previous Clinical Trials
886,244 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,392 Previous Clinical Trials
26,529,395 Total Patients Enrolled
2 Trials studying Tic Disorders
274 Patients Enrolled for Tic Disorders
Frank P MacMaster, PhDPrincipal InvestigatorUniversity of Calgary
2 Previous Clinical Trials
63 Total Patients Enrolled
~8 spots leftby Dec 2025
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