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Focused Ultrasound

Patients with Multiple Sclerosis and Tremor for Multiple Sclerosis (MSFUS001 Trial)

N/A
Waitlist Available
Led By Nir Lipsman, MD, PhD
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1, 7, 30, 90 and 120 days
Awards & highlights

Summary

This trial will test a new treatment using focused sound waves to reduce hand tremors in MS patients. The sound waves target and destroy a small part of the brain causing the tremors. This method has been previously approved for treating other types of tremors and has shown promise in treating MS-associated tremor.

Eligible Conditions
  • Multiple Sclerosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1, 7, 30, 90 and 120 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1, 7, 30, 90 and 120 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Change from baseline in the CRST (Clinical Rating Scale for Tremors)
Changes from baseline in QUEST (Quality of Life in Essential Tremor Questionnaire) scores
Changes from baseline in the EDSS (Expanded Disability Status Scale) scores
+5 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with Multiple Sclerosis and TremorExperimental Treatment1 Intervention
Participants will undergo MRgFUS thermal ablation of the ventral intermedius (Vim) thalamus contralateral to the most affected side of the body.

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Who is running the clinical trial?

Multiple Sclerosis Society of CanadaOTHER
15 Previous Clinical Trials
1,041 Total Patients Enrolled
15 Trials studying Multiple Sclerosis
1,041 Patients Enrolled for Multiple Sclerosis
Sunnybrook Health Sciences CentreLead Sponsor
661 Previous Clinical Trials
1,554,045 Total Patients Enrolled
5 Trials studying Multiple Sclerosis
612 Patients Enrolled for Multiple Sclerosis
Nir Lipsman, MD, PhDPrincipal InvestigatorSunnybrook Health Sciences Centre
3 Previous Clinical Trials
28 Total Patients Enrolled
~1 spots leftby Sep 2025
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