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CPAP Devices for Breast and Lung Cancer

N/A

Recruiting

Led By Sheeh Cherian, MD

Research Sponsored by Case Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must be undergoing left breast/chest wall radiation with or without regional nodal irradiation

Patients with left-sided breast cancers

Must not have

Patients with right side breast cancer

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at the time of scan, " day 1"

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether using a CPAP device can help improve outcomes for patients with left-sided breast cancer or lung SBRT.

Who is the study for?

This trial is for patients with left-sided breast cancer or those undergoing lung SBRT, including cases of metastatic and primary lung cancers. It's not suitable for individuals with right-side breast cancer or those who cannot tolerate a CPAP device.

What is being tested?

The study is evaluating the use of CPAP devices during radiation therapy to see if they can reduce the amount of radiation received by the lungs in patients with certain types of breast and lung cancers.

What are the potential side effects?

While this trial focuses on data collection rather than drug effects, using a CPAP device may cause discomfort, difficulty sleeping, dry mouth or nose, and possible skin irritation where the mask contacts the face.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am receiving radiation therapy on my left breast or chest wall, possibly including nearby lymph nodes.

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My breast cancer is in the left breast.

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I am receiving targeted radiation therapy for my lung.

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My cancer has spread to my lungs.

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My cancer originated in my lungs.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

My breast cancer is in the right breast.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at the time of scan, " day 1"

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at the time of scan, " day 1"

This trial's timeline: 3 weeks for screening, Varies for treatment, and at the time of scan, " day 1" for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Dosimetry comparison CPAP and free breathing.

Secondary study objectives

Cardiac dosimetry with CPAP as compared to free breathing

Confirm maintenance of inflation with CPAP using surface guidance

Measure breast/chest wall or lung tumor motion as well as organ at risk motion

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Active Control

Group I: Lung SBRTActive Control3 Interventions

Participants will come in for their regularly scheduled radiation planning and treatment. Participants will undergo three scans (with and without DIBH (i.e., free-breathing), with CPAP). Participants will also use the CPAP device before the CT scan, for which they will be educated and trained.

Group II: left-sided breast cancerActive Control3 Interventions

0 / 6Eligibility criteria met