Repetitive Transcranial Magnetic Stimulation in Women With Overactive Bladder With Urgency Incontinence

Phase < 1

Waitlist Available

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up feasibility will be assessed after completion of the study, up to 6 months.

Awards & highlights

No Placebo-Only Group

Summary

This trial tests if rTMS, a procedure using magnetic fields to stimulate brain cells, can help women with overactive bladder and urgency urinary incontinence. By targeting brain areas that control bladder muscles, rTMS may improve bladder control and reduce urgent urination.

Eligible Conditions

Overactive Bladder
Urge Incontinence

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ feasibility will be assessed after completion of the study, up to 6 months.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~feasibility will be assessed after completion of the study, up to 6 months.

This trial's timeline: 3 weeks for screening, Varies for treatment, and feasibility will be assessed after completion of the study, up to 6 months. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Effects of rTMS on pelvic floor muscle activity after high-frequency rTMS

Effects of rTMS on pelvic floor muscle activity after low-frequency rTMS

Effects of rTMS on pelvic-SMA activity after high-frequency rTMS

+1 more

Secondary study objectives

Assess objective OAB and UUI symptom changes following rTMS

Assess subjective OAB and UUI symptom changes following rTMS

Other study objectives

Feasibility of repetitive transcranial magnetic stimulation (rTMS) use in women with overactive bladder (OAB) and urgency urinary incontinence (UUI)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Low Frequency rTMS ProtocolExperimental Treatment1 Intervention

Low frequency 1 Hz at 80% motor threshold intensity with figure-of-eight coil for a total of 2,000 pulses. Pulses will be delivered continuously.

Group II: High Frequency rTMS ProtocolExperimental Treatment1 Intervention

High frequency with 10 Hz at 80% motor threshold intensity with figure-of-eight coil for a total of 2,000 pulses. Pulses will be delivered in 10-second trains with a 50-second pause between the trains.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Repetitive Transcranial Magnetic Stimulation

2013

Completed Phase 3

~1170

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