What side effects are associated with this type of intervention?

Common treatments for prediabetes often involve lifestyle modifications, including increased consumption of fruits, vegetables, and healthy fats, which are rich in bioactive compounds like antioxidants and vitamins. These dietary changes generally have minimal side effects. However, some individuals may experience gastrointestinal discomfort, such as bloating or gas, when increasing fiber intake rapidly. Additionally, while rare, allergic reactions to specific fruits or vegetables can occur. Overall, these dietary interventions are considered safe and beneficial for most people.

What prior FDA approvals exist?

The FDA has not specifically approved any drugs solely for the treatment of prediabetes. However, lifestyle interventions, including dietary changes, are commonly recommended. Treatments focusing on bioactive compounds like antioxidants, vitamins, and healthy fats, similar to those found in avocados and mangoes, are being studied for their potential benefits. These compounds may help improve vascular function and overall metabolic health, but more research is needed to confirm their efficacy and safety.

What other types of research exist?

Promising alternatives to avocado and mango for prediabetes patients include: <ol> <li>Nuts and Seeds: Almonds, walnuts, and chia seeds are rich in healthy fats, fiber, and antioxidants.</li> <li>Berries: Blueberries, strawberries, and raspberries are high in antioxidants, fiber, and vitamins.</li> <li>Leafy Greens: Spinach, kale, and Swiss chard provide fiber, vitamins A, C, and K, and various antioxidants.</li> <li>Olive Oil: Rich in monounsaturated fats and antioxidants, it can be used as a healthy fat source.</li> <li>Fatty Fish: Salmon, mackerel, and sardines are excellent sources of omega-3 fatty acids and vitamin D.</li> </ol>

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Avocado Mango for Pre-diabetes (AVMa Trial)

N/A

Waitlist Available

Led By Britt Burton-Freeman, Ph.D

Research Sponsored by Clinical Nutrition Research Center, Illinois Institute of Technology

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline-8 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial tests if eating one avocado and one mango daily can help people with prediabetes by improving their blood vessel health, cognitive function, and kidney function. Mangos have shown antidiabetic, anti-inflammatory, and heart-protective properties.

Who is the study for?

This trial is for men and women aged 25-70 with prediabetes, having fasting blood glucose levels between 100-125 mg/dL. Participants should be in good health without major diseases or recent surgeries that could affect the study's results. They shouldn't take medications or supplements that might interfere with outcomes, must not abuse substances, and non-smokers are preferred.

What is being tested?

The study tests how eating avocados and mangos affects vascular function over 8 weeks compared to a control diet. It measures changes in artery flexibility, blood pressure, eye vessel health using OCTA technology, cognitive performance through specific tasks, and kidney function indicators.

What are the potential side effects?

While the trial does not focus on side effects of avocado and mango consumption directly, potential side effects may include digestive discomfort or food-related allergies for those sensitive to these fruits.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline-8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline-8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline-8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Changes in Central Blood pressure

Changes in Kidney function markers

Changes in Pulse Wave Velocity

+9 more

Secondary study objectives

Changes in Cognitive Function

Changes in Cognitive Function-1

Changes in Cognitive Function-2

+7 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Control meal planExperimental Treatment1 Intervention

2 meals and snacks per day, without avocado and mango, covering 75% of daily calories needs

Group II: Avocado mango meal planExperimental Treatment1 Intervention

2 meals and snacks per day, including 1 avocado + 1 cup of mango, covering 75% of daily calories needs,

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for prediabetes often include dietary interventions that focus on the intake of bioactive compounds such as antioxidants, vitamins, and healthy fats. These compounds can improve insulin sensitivity, reduce oxidative stress, and enhance vascular function. For example, antioxidants help neutralize free radicals, reducing inflammation and oxidative damage to cells, which is crucial for maintaining healthy blood sugar levels. Vitamins, particularly those with anti-inflammatory properties, support metabolic processes and improve insulin function. Healthy fats, such as those found in avocados, can improve lipid profiles and reduce insulin resistance. These mechanisms are vital for prediabetes patients as they help prevent the progression to type 2 diabetes and reduce the risk of associated cardiovascular complications.

Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds.