Nutrition & Strength Training for Osteoporosis

(INVEST Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Kristen Beavers, PhD, MPH, RD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Wake Forest University Health Sciences

No Placebo Group

Trial Summary

What is the purpose of this trial?

The main goal of the proposed study is to compare the effects of weight loss (WL) alone with WL plus weighted vest use or WL plus resistance exercise training (RT) on indicators of bone health and subsequent fracture risk.

Research Team

Kristen Beavers, PhD, MPH, RD

Principal Investigator

Wake Forest University Health Sciences

Eligibility Criteria

This trial is for adults aged 60-85 with a BMI between 27 and 40, who are stable in weight, can attend virtual sessions, and travel to visits. It's not for those with severe arthritis, recent major surgeries or metal implants in the hip/pelvis area, uncontrolled health conditions like hypertension or diabetes, heavy medication use including steroids or osteoporosis drugs, cognitive impairments, smokers or excessive drinkers.

Inclusion Criteria

I am between 60 and 85 years old.

I agree to participate, follow the study's procedures, and can get myself to visits.

My BMI is between 27 and 40, and I may have a risk factor if it's under 30.

Exclusion Criteria

You have difficulty following a specific diet, wearing a vest, or undergoing a CT scan due to feeling claustrophobic.

You smoke more than one cigarette per day or have smoked at least four cigarettes per week in the past year. You also consume more than 14 alcoholic drinks per week.

Anemia (Hb <13 g/dL in men/<12 g/dL in women)

Treatment Details

Interventions

• Resistance Exercise Training (Strength Training)
• Vest (Device)
• Weight Loss Program (Behavioural Intervention)

Trial Overview The study compares three approaches to improve bone health and reduce fracture risk: weight loss alone (WL), WL plus wearing a weighted vest (Vest), and WL combined with resistance exercise training (RT). Participants will be assessed on how these methods affect their bones.

Participant Groups

Group I: Weight Loss plus Vest Experimental Treatment 2 Interventions

Group II: Weight Loss Plus Resistance Exercise Training Active Control 2 Interventions

Group III: Weight Loss Active Control 1 Intervention

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Wake Forest University School of Medicine Winston-Salem, NC

Who Is Running the Clinical Trial?

Wake Forest University Health Sciences

Lead Sponsor

Trials

1432

Patients Recruited

2,506,000+