Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen by Charles Van Way, III, M.D.

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Missouri, Kansas City

Trial Summary

What is the purpose of this trial?

Overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield, in civilian life, or which can be used during initial resuscitation in the first fixed facility to which the injured patient is brought.

Research Team

Charles Van Way, III, M.D.

Principal Investigator

University of Missouri, Kansas City

Eligibility Criteria

Inclusion Criteria

Blunt or penetrating trauma patients who meet Truman Medical Center criteria for a trauma activation.

These patients will typically be in shock and have blunt injuries or penetrating trauma.

Patients must be alert, awake, oriented, and responsive and be English speaking males or females between the ages 21-65.

Treatment Details

Interventions

• Glutamine (Other)
• Placebo (Other)
• Ringer's Lactate (Other)
• Standard Trauma Resuscitation Therapy (Other)

Participant Groups

Group I: Ringer's Lactate with 25 grams Glutamine Experimental Treatment 2 Interventions

Ringer's Lactate with 25 grams Glutamine (1 liter) once over 6 hours

Group II: Ringer's Lactate and Placebo for Glutamine Placebo Group 2 Interventions

Ringer's Lactate 1 liter once over 6 hours

Who Is Running the Clinical Trial?

University of Missouri, Kansas City

Lead Sponsor

Trials

73

Recruited

34,600+

Donald Jeff Keyser

University of Missouri, Kansas City

Chief Executive Officer since 2017

PhD in Economics from The University of Texas at Dallas

Edwina Baskin-Bey

University of Missouri, Kansas City

Chief Medical Officer

MD from Mount Sinai/NYU School of Medicine

United States Department of Defense

Collaborator

Trials

940

Recruited

339,000+

Pete Hegseth

United States Department of Defense

Chief Executive Officer

Bachelor's degree in Political Science from Princeton University, JD from Harvard Law School

Lisa Hershman

United States Department of Defense

Chief Medical Officer since 2021

MD from Uniformed Services University of the Health Sciences