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Arthur G. James Cancer Hospital - Ohio State University

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Columbus, Ohio 43202

Global Leader in Lymphoma

Global Leader in Lung Cancer

Conducts research for Breast Cancer

Conducts research for Leukemia

Conducts research for Cancer

491 reported clinical trials

16 medical researchers

Photo of Arthur G. James Cancer Hospital - Ohio State University in ColumbusPhoto of Arthur G. James Cancer Hospital - Ohio State University in ColumbusPhoto of Arthur G. James Cancer Hospital - Ohio State University in Columbus

Summary

Arthur G. James Cancer Hospital - Ohio State University is a medical facility located in Columbus, Ohio. This center is recognized for care of Lymphoma, Lung Cancer, Breast Cancer, Leukemia, Cancer and other specialties. Arthur G. James Cancer Hospital - Ohio State University is involved with conducting 491 clinical trials across 357 conditions. There are 16 research doctors associated with this hospital, such as Uma Borate, MD, Alice Mims, Sagar Sardesai, MD, and David O'Malley, MD.

Area of expertise

1

Lymphoma

Global Leader

Arthur G. James Cancer Hospital - Ohio State University has run 61 trials for Lymphoma. Some of their research focus areas include:

Stage IV
Stage III
CCND1 positive
2

Lung Cancer

Global Leader

Arthur G. James Cancer Hospital - Ohio State University has run 52 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
BRAF positive

Top PIs

Clinical Trials running at Arthur G. James Cancer Hospital - Ohio State University

Acute Myeloid Leukemia

Myelofibrosis

Chronic Lymphocytic Leukemia

Lung Cancer

Multiple Myeloma

Follicular Lymphoma

Mantle Cell Lymphoma

Myelodysplastic Syndrome

Leukemia

Acute Myelogenous Leukemia

Image of trial facility.

SEA-CD70

for Myelodysplastic Syndrome and Acute Myeloid Leukemia

This trial is testing a new drug, SEA-CD70, alone and with azacitidine, to see if it is safe and works for adults with certain blood cancers that haven't responded to other treatments. The study will determine the best dose and check for side effects. Azacitidine is a treatment that improves survival, reduces the need for transfusions, and lowers the risk of progression to acute myeloid leukemia in patients with higher risk myelodysplastic syndromes.

Recruiting

1 award

Phase 1

10 criteria

Image of trial facility.

Emavusertib (+ Venetoclax)

for Acute Myeloid Leukemia

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS). Patients enrolling in the Phase 1 dose escalation of the study must meet one of the following criteria prior to consenting to the study: * Relapse/refractory (R/R) AML with FMS-like tyrosine kinase-3 (FLT3) mutations who have been previously treated with a FLT3 inhibitor * R/R AML with spliceosome mutations of splicing factor 3B subunit 1 (SF3B1) or U2AF1 * R/R hrMDS with spliceosome mutations of SF3B1 or U2 small nuclear RNA auxiliary factor 1 (U2AF1) * Number of pretreatments: 1 or 2 The Phase 2a Dose Expansion will be in 3 Cohorts of patients: 1. R/R AML with FLT3 mutations who have been previously treated with a FLT3 inhibitor; 2. R/R AML with spliceosome mutations of SF3B1 or U2AF1; and 3. R/R hrMDS (Revised International Prognostic Scoring System \[IPSS-R\] score \> 3.5) with spliceosome mutations of SF3B1 or U2AF1. All patients above have had ≤ 2 lines of prior systemic anticancer treatment. In previous versions of this protocol there was a Phase 1b portion of the study, in which patients with AML or hrMDS received CA-4948 in combination with venetoclax. This part of the study is no longer open for enrollment.

Recruiting

1 award

Phase 1 & 2

9 criteria

Image of trial facility.

Quizartinib + Chemotherapy

for Leukemia

This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).

Recruiting

1 award

Phase 3

4 criteria

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