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Toronto General Hospital

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TORONTO, Ontario M5G 2C4

Global Leader in Lung Cancer

Global Leader in Heart Failure

Conducts research for Cardiovascular Disease

Conducts research for Heart Disease

Conducts research for Coronary Artery Disease

396 reported clinical trials

25 medical researchers

Photo of Toronto General Hospital in TORONTOPhoto of Toronto General Hospital in TORONTOPhoto of Toronto General Hospital in TORONTO

Summary

Toronto General Hospital is a medical facility located in TORONTO, Ontario. This center is recognized for care of Lung Cancer, Heart Failure, Cardiovascular Disease, Heart Disease, Coronary Artery Disease and other specialties. Toronto General Hospital is involved with conducting 396 clinical trials across 515 conditions. There are 25 research doctors associated with this hospital, such as Gary Lewis, MD, Eric Horlick, MD, David Cherney, and Vivek Rao, MD.

Area of expertise

1

Lung Cancer

Global Leader

Toronto General Hospital has run 27 trials for Lung Cancer. Some of their research focus areas include:

Stage I
Stage II
Stage III
2

Heart Failure

Global Leader

Toronto General Hospital has run 21 trials for Heart Failure.

Top PIs

Clinical Trials running at Toronto General Hospital

Paroxysmal Nocturnal Hemoglobinuria

Coronary Artery Disease

Chronic Kidney Disease

Bipolar Disorder

Chronic Renal Failure

Lung Cancer

Heart Failure

Heart Disease

Cardiovascular Disease

Hepatitis C

Image of trial facility.

Pozelimab + Cemdisiran

for Paroxysmal Nocturnal Hemoglobinuria

This study is researching an experimental treatment combination with two experimental drugs called pozelimab and cemdisiran. The study is focused on people with paroxysmal nocturnal hemoglobinuria (PNH). The aim of this study is to see how safe and effective the pozelimab + cemdisiran combination is for people with PNH in the long term. The pozelimab + cemdisiran combination may be referred to as "study drugs" in this section. This study is looking at several other research questions, including: * How effective is the pozelimab + cemdisiran combination? * What side effects may happen from taking the study drugs? * How much of each study drug is in the blood at different times? * Whether the body makes antibodies against the study drugs (which could make the drugs less effective or could lead to side effects)

Recruiting

2 awards

Phase 3

8 criteria

Image of trial facility.

Pozelimab + Cemdisiran

for Paroxysmal Nocturnal Hemoglobinuria

This trial is testing a new combination of two drugs, pozelimab and cemdisiran, for patients with a rare blood disorder called PNH. The goal is to see if this new combination is safe and works better than current treatments. Researchers will also check for side effects and how the body reacts to the drugs. Eculizumab is the first approved treatment for PNH and has significantly changed the treatment landscape by inhibiting terminal complement activation.

Recruiting

2 awards

Phase 3

3 criteria

Image of trial facility.

ALN-CFB

for Paroxysmal Nocturnal Hemoglobinuria

This study is researching an experimental drug called ALN-CFB. The study is focused on people with Paroxysmal Nocturnal Hemoglobinuria (PNH) who are currently taking a complement component C5 inhibitor ("C5-inhibitor") and continue to have anemia (low red blood cell count). The aim of the study is to see how tolerable ALN-CFB is compared to placebo. A placebo looks like the study drug but does not contain any drug. The study is looking at several other research questions, including: * What side effects may happen from taking ALN-CFB * How much ALN-CFB is in the blood at different times * How much Complement Factor B (CFB) protein levels in the blood are affected by ALN-CFB

Recruiting

0 awards

Phase 1 & 2

2 criteria

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