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University Health Network

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TORONTO, Ontario M5G 2C4

Global Leader in Prostate Cancer

Global Leader in Cancer

Conducts research for Lung Cancer

Conducts research for Depression

Conducts research for Breast Cancer

541 reported clinical trials

60 medical researchers

Photo of University Health Network in TORONTOPhoto of University Health Network in TORONTOPhoto of University Health Network in TORONTO

Summary

University Health Network is a medical facility located in TORONTO, Ontario. This center is recognized for care of Prostate Cancer, Cancer, Lung Cancer, Depression, Breast Cancer and other specialties. University Health Network is involved with conducting 541 clinical trials across 709 conditions. There are 60 research doctors associated with this hospital, such as Lillian Siu, MD, Marcus Butler, Anna Spreafico, MD PhD, and Peter Chung, MD.

Area of expertise

1

Prostate Cancer

Global Leader

University Health Network has run 33 trials for Prostate Cancer. Some of their research focus areas include:

Stage IV
2

Cancer

Global Leader

University Health Network has run 29 trials for Cancer. Some of their research focus areas include:

Stage IV
TP53 positive
MET positive

Top PIs

Clinical Trials running at University Health Network

Breast Cancer

Cancer

Prostate Cancer

Bladder Cancer

Brain Tumor

Melanoma

Multiple Myeloma

Thalassemia

Pancreatic Cancer

Colorectal Cancer

Image of trial facility.

Sentinel Lymph Node Biopsy

for Breast Cancer

This is a prospective, open-label, within-patient clinical trial to determine the accuracy of Indocyanine green (ICG) guided sentinel lymph node biopsy (SLNB) compared to the standard dual-tracer SLNB in breast cancer patients who have had chemotherapy as a first treatment using a non-inferiority design. Patients with operable breast cancer treated with chemotherapy and eligible for SLNB will be included in the study. During surgery, ICG will be injected and used to identify fluorescent sentinel nodes using a hand-held imaging camera; radiotracer and blue dye will also be used as per standard protocols. Intraoperative and clinicopathologic outcomes such as complications, characteristics of nodes, false negative rates and feasibility will be assessed. Patients will be asked to complete standardized patient reported outcome questionnaires (Breast-Q, FACT-B+4, VAS) to define the patient experience with this novel technique.

Recruiting

1 award

N/A

6 criteria

Image of trial facility.

Anakinra

for Breast Cancer

This study will examine changes in the tumor microenvironment (TME) induced by 14 days of pre-operative IL-1-inhibiting therapy among patients with early breast cancer (including TNBC and ER-low positive). Key immune biomarkers (TILs, TAMs, NK cells, IL1\[beta\] and inflammasome component expression) will be evaluated at baseline and following 14 days of IL-1 antagonist therapy (Anakinra) using paired tissue specimens.

Recruiting

1 award

Phase 2

3 criteria

Image of trial facility.

PEM vs Liquid Biopsy

for Breast Cancer

The goal of this research study is to evaluate the performance of two experimental tests, namely Liquid Biopsy and Positron Emission Mammography (PEM) in women at high risk of breast cancer. The plan for this study is to assess whether findings from the combination or each individual test can assist radiologists in visualizing and characterizing beast abnormalities. Liquid Biopsy is a blood test that can detect early tumours in patients with malignancies, while PEM is an imaging tool equipped with a high-resolution camera that uses a low dose of injected positron emitting isotope to locate breast tumours. Participation in this study entails a blood draw for Liquid Biopsy test and a PEM imaging exam before undergoing a magnetic resonance imaging (MRI) - guided biopsy for a suspicious breast lesion. If PEM and/or Liquid Biopsy provide accurate information to assist radiologists in visualizing and characterizing breast abnormalities, this method may serve as the first step towards establishing these genomic and new imaging technologies as new diagnostic modalities and ultimately reduce the unnecessary biopsies and anxiety in high-risk populations.

Recruiting

1 award

N/A

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