Behavioral Intervention
Prehabilitation for Abdominal Aortic Aneurysm Repair
This trial will look at whether a pre-op program of exercise, nutrition, and psych support can help people with an artery enlargement in the abdomen to reduce complications after surgery.
Procedure
CSF Drain Placement for Aortic Aneurysm
This trial aims to see if using CSF drains before surgery can prevent spinal cord injury in patients having endovascular thoracoabdominal aneurysm repair. The study focuses on patients at risk of spinal cord injury due to reduced blood flow during the procedure. CSF drains help by lowering pressure around the spinal cord, improving blood flow and potentially preventing injury. CSF drainage has been used to protect the spinal cord during thoracic and thoracoabdominal aortic surgeries by reducing the risk of paraplegia.
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Trials for AAA Patients
Endovascular Repair
EVAR vs ESAR for Abdominal Aortic Aneurysm
This trial compares two methods of repairing abdominal aortic aneurysms in patients with wide aortic necks. One method uses a stent graft alone, while the other adds extra anchors to secure the graft. The goal is to see which method works better for these patients.
Procedure
Endovascular Repair for Aortic Aneurysm
This trial tests special medical devices, either custom-made or pre-made, to fix weakened areas in the main blood vessel (aorta) in patients with specific types of aortic aneurysms. These devices support the weakened sections to prevent them from rupturing. The Zenith platform has been used in various studies for treating complex aortic aneurysms.
Trials for Thoracoabdominal Aortic Aneurysms Patients
Endovascular Graft
Endovascular Graft Repair for Aortic Aneurysm
This trial is testing a new device to treat complex aortic aneurysms and thoracoabdominal aortic aneurysms in high-risk patients. The trial will assess the safety and preliminary effectiveness of the device, as well as renal function, radiation exposure, and quality of life.
Endovascular Device
Aortic Endografts for Aortic Aneurysm
This trial is testing three investigational devices to see if they're safe and effective for treating aortic pathologies involving the visceral vessels. This approach has the potential to decrease hospital length of stay, pulmonary complications, and in-hospital mortality.
Trials With No Placebo
Endovascular Repair
EVAR vs ESAR for Abdominal Aortic Aneurysm
This trial compares two methods of repairing abdominal aortic aneurysms in patients with wide aortic necks. One method uses a stent graft alone, while the other adds extra anchors to secure the graft. The goal is to see which method works better for these patients.
Procedure
Endovascular Repair for Aortic Aneurysm
This trial tests special medical devices, either custom-made or pre-made, to fix weakened areas in the main blood vessel (aorta) in patients with specific types of aortic aneurysms. These devices support the weakened sections to prevent them from rupturing. The Zenith platform has been used in various studies for treating complex aortic aneurysms.
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Frequently Asked Questions
Introduction to abdominal aortic aneurysm
What are the top hospitals conducting abdominal aortic aneurysm research?
Advancements in medical research continue to revolutionize the treatment of abdominal aortic aneurysm, and several top hospitals are leading the charge. In Boston, Massachusetts General Hospital is at the forefront with two ongoing clinical trials dedicated to this condition. Over the years, they have conducted a remarkable 12 trials focusing on abdominal aortic aneurysms since their first recorded trial in 2005. Meanwhile, in Grand Rapids, Spectrum Health System has emerged as another prominent institution addressing this health issue. They currently have two active trials and have contributed to three previous studies since initiating their first trial in 2011.
Further down south, Mission Hospital located in Asheville has also made significant contributions by conducting five total abdominal aortic aneurysm trials thus far while having just begun their journey into researching this condition back in 2010. Not to be outdone, Cleveland Clinic Foundation has been actively involved with six past investigations related to abdominal aortic aneurysms following its inception of undertaking such tests starting from year2005; meanwhile maintaining current involvement through two active ongoing ones for better understanding of it's intricate workings.
Lastly but not least University of Pittsburgh Medical Center based hospital sets itself apart as well by embarking on eight separate explorations regarding these types after kicking off such projects way back right same year when Cleveland began theirs whose present status still holds strong through participation within two different recent experiments.
These hospitals represent pillars of innovation and expertise when it comes to tackling abdominal aortic aneurysms head-on. Through collective efforts and tireless dedication towards groundbreaking clinical trials, researchers strive toward improving outcomes for individuals affected by this potentially life-threatening condition that affects the large blood vessel supplying oxygenated blood to our vital organs situated deep within our abdomen including kidneys liver intestines etc., making them emblematic examples pushing boundaries towards transforming medical landscape positively
Which are the best cities for abdominal aortic aneurysm clinical trials?
When it comes to abdominal aortic aneurysm clinical trials, several cities emerge as key players in advancing research and treatment options. Among them are Birmingham, Alabama; Phoenix, Arizona; Sioux Falls, South dakota; Houston, Texas; and Boston Massachusetts. Each of these cities currently hosts multiple active trials focused on innovative interventions such as the GORE® EXCLUDER® Conformable AAA Endoprosthesis and the Treovance stent-graft. With their commitment to cutting-edge research and advancements in care, these cities provide individuals with abdominal aortic aneurysms access to potential breakthrough treatments that can improve outcomes and quality of life.
Which are the top treatments for abdominal aortic aneurysm being explored in clinical trials?
Abdominal aortic aneurysm clinical trials are exploring several innovative treatments to combat this condition. Among the top contenders is Multimodal Prehabilitation, currently being tested in one active trial since its first listing in 2023. Another promising option is the Physician-Modified Cook Zenith Alpha Thoracic Endovascular Graft, which has also caught attention with one ongoing trial and was first listed in 2021. Additionally, researchers are investigating the potential of the GORE® EXCLUDER® Conformable AAA Endoprosthesis, which made its debut in 2017 and is currently under evaluation in one active abdominal aortic aneurysm trial. With these novel approaches on the horizon, there is hope for improved outcomes for individuals grappling with abdominal aortic aneurysms.
What are the most recent clinical trials for abdominal aortic aneurysm?
Exciting advancements in the field of abdominal aortic aneurysm research offer hope for patients diagnosed with this condition. One recent clinical trial focuses on evaluating the effectiveness of the Treovance stent-graft as a potential treatment option. This innovative Phase 2 study, available since 11/23/2013, aims to assess the outcomes and safety profile associated with using this device in individuals with abdominal aortic aneurysms. Additionally, another significant Phase 3 trial conducted since 9/1/2006 examines various treatments for abdominal aortic aneurysm, aiming to enhance patient care and ultimately improve long-term prognosis. These groundbreaking trials contribute valuable insights that may shape future treatment approaches for individuals affected by abdominal aortic aneurysms.
What abdominal aortic aneurysm clinical trials were recently completed?
Several noteworthy clinical trials focusing on abdominal aortic aneurysm have recently concluded, presenting advancements in the management of this condition. In October 2021, a trial sponsored by the University Hospitals Cleveland Medical Center investigated the effectiveness of endovascular repair techniques. Another study led by Johns Hopkins Medicine examined biomarkers for risk assessment and was completed in September 2021. Additionally, a trial exploring innovative imaging modalities to enhance diagnosis and monitoring reached completion in January 2021. These recent achievements shed light on ongoing efforts to improve treatment options and patient outcomes for individuals with abdominal aortic aneurysms.