Hallucinogenic Drug
Psilocybin for Depression and Alcoholism
This trial is testing if psilocybin can help people with both depression and alcohol problems. The drug might improve mood and reduce drinking by changing brain activity. The study involves giving psilocybin to see if it helps. Psilocybin is a naturally occurring psychedelic that has shown promise in treating mood and substance use disorders.
Behavioral Intervention
Oxytocin + COPE Therapy for Alcoholism and PTSD
This trial will compare oxytocin to a placebo in reducing symptoms of alcohol use disorder and post-traumatic stress disorder in veterans receiving COPE therapy. Brain scans will be used to examine potential mechanisms of change.
Serotonin/Dopamine Activity Modulator
Brexpiprazole for Alcoholism
This trial tests whether brexpiprazole can help reduce alcohol consumption in people with Alcohol Use Disorder who are not seeking treatment. The medication works by balancing brain chemicals related to mood and behavior. Researchers will also see if genetic differences affect how well the medication works. Brexpiprazole is a newer medication related to aripiprazole, which has shown potential in reducing alcohol use by stabilizing dopamine and serotonin systems.
COMT Inhibitor
Tolcapone for Alcoholism and ADHD
This trial tests tolcapone to see if it helps people with both alcohol use issues and attention problems. The study focuses on people with both AUD and ADHD. Tolcapone works by affecting brain chemicals related to mood and behavior. Initially used for Parkinson's disease, tolcapone might be considered for ADHD treatment.
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Trials for Alcohol Use Disorder Patients
Behavioural Intervention
Parent-Child Assistance Program for Substance Use During Pregnancy
This trial helps 200 mothers in Oklahoma who use alcohol/drugs during pregnancy & their children by providing support/resources for 3 years. Benefits include substance use disorder treatment, birth control, abstinence, child custody, & criminal justice involvement.
Behavioural Intervention
Psycho-education & Understanding Bipolar Medications Therapy + MBSR + ISRT + Bipolar-Specific CBT for Bipolar Disorder
This trial will study how to better treat bipolar patients who are suicidal by looking at environmental and psychological factors, as well as implementing a 6-week intervention program.
Trials for Binge Drinking Patients
Neuroeconomic Decision-Making for Alcoholism
This trial uses techniques from neuroeconomics, which is a mix of psychology, neuroscience, and economics, to study how the brain makes decisions about alcohol consumption. They will be using functional magnetic resonance imaging (fMRI) to look at brain activity while participants make hypothetical decisions about alcohol consumption at various prices. There will be an in-scanner alcohol cue exposure task where participants will view images of alcoholic or neutral beverages before making their decisions.
Trials With No Placebo
Behavioural Intervention
Parent-Child Assistance Program for Substance Use During Pregnancy
This trial helps 200 mothers in Oklahoma who use alcohol/drugs during pregnancy & their children by providing support/resources for 3 years. Benefits include substance use disorder treatment, birth control, abstinence, child custody, & criminal justice involvement.
Behavioural Intervention
Neural and Hormonal Influences on Alcohol Use Disorder Risk
This trial is looking at the neural and hormonal factors that contribute to why women are more at risk for AUD than men. They will be looking at three addiction domains: inhibitory control (executive function), negative emotionality, and alcohol cue reactivity (incentive salience).
Behavioural Intervention
Psycho-education & Understanding Bipolar Medications Therapy + MBSR + ISRT + Bipolar-Specific CBT for Bipolar Disorder
This trial will study how to better treat bipolar patients who are suicidal by looking at environmental and psychological factors, as well as implementing a 6-week intervention program.
Behavioral Intervention
Weaving Healthy Families Program for Substance Use and Domestic Violence
This trial is testing a program to reduce alcohol and drug abuse and violence in families among Native Americans in order to promote health and wellness. The expected outcomes are a reduction in abuse and violence and promotion of resilience and wellness.
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Frequently Asked Questions
Introduction to alcoholism
What are the top hospitals conducting alcoholism research?
When it comes to the battle against alcoholism, top hospitals are stepping up to the plate with innovative clinical trials aimed at finding effective treatments. In Charleston, South carolina, the Medical University of South Carolina leads the way with four active trials and a total of 25 trials conducted throughout their history. Since their first recorded alcoholism trial in 2009, this institution has been committed to exploring new avenues for helping those struggling with addiction. Meanwhile, in Philadelphia's University of Pennsylvania Center for Studies of Addiction, researchers are currently engaged in three ongoing alcoholism trials as they kickstart their journey into understanding this complex condition. Despite having only completed four studies since recording their initial trial in 2021, this center is making waves in the field.
At the University of Colorado Anschutz Medical Campus located in Aurora, three active alcoholism trials are taking place. Though relatively new to studying alcoholism compared to other institutions on this list (with their first recorded trial dating back only to 2020), they have already demonstrated a dedication towards advancing our knowledge and treatment options for individuals affected by alcohol addiction.
Notably contributing as well is Yale University situated in New Haven where two current clinical tests focus on combating alcoholism. With five previous investigations under its belt since initiating research efforts backin2016,Yale continues pushing forward toward breakthroughs that can transform lives.
Rounding out these leading medical centers is another establishment from Philadelphia—the University of Pennsylvania—where two active clinical trials concentrate on tackling alcoholism head-on.They have completed thirteen all-time studies thus far after embarking upon pioneering endeavors concerning such cases since1998
These hospitals' commitment and tireless efforts underline how crucial it is to find solutions for those grappling with addiction while fostering a sense of hope that through continued research we will uncover novel interventions and approaches leading us towards a society where recovery from Alcohol Use Disorder becomes more attainable than ever before
Which are the best cities for alcoholism clinical trials?
Providence, Rhode island, emerges as one of the top cities for alcoholism clinical trials with 9 ongoing studies focusing on Alcohol Use Disorder Only, Motivational + Family Check-up (MET+FCU), and Lamotrigine among others. Baltimore, Maryland follows closely behind with 7 active trials exploring interventions like Mifepristone, Pregabalin plus BBCET, and Intranasal Oxytocin. New Haven, Connecticut showcases its commitment to research with 6 ongoing trials investigating treatments such as patients receiving 300mg PREG, Active Treatment, and Guanfacine ER. Lastly, Philadelphia in Pennsylvania and New york City both contribute to advancing alcoholism treatment through their respective active trials including XR-NTX 380 mg intramuscular injection and Adaptive Tailored (TA) approaches. These cities offer individuals struggling with alcoholism opportunities to participate in innovative clinical trials that may improve outcomes for this challenging condition.
Which are the top treatments for alcoholism being explored in clinical trials?
Exciting advancements are taking place in the realm of alcoholism treatment, with clinical trials investigating several promising approaches. One notable contender is oxytocin, currently being explored in two active trials and a total of nine all-time alcoholism trials since its introduction in 2014. Another intriguing avenue under investigation is the use of alcohol itself as a potential treatment, with two ongoing trials and twelve all-time trials dedicated to exploring this unconventional approach since 2008. These innovative studies hold great promise for improving outcomes and providing new avenues for individuals struggling with alcoholism.
What are the most recent clinical trials for alcoholism?
Recent clinical trials have brought new hope for individuals struggling with alcoholism. One promising study investigated the effectiveness of Semaglutide, administered in 3 milligram and 7 milligram doses, as a potential treatment option. Another trial focused on Acetyl-l-carnitine and its impact on alcohol dependency. Additionally, Semaglutide was also studied independently to assess its effectiveness in combating alcoholism. Full-spectrum Cannabidiol has shown promise in Phase 2 and Phase 3 trials for treating alcohol use disorder. Lastly, Ibudilast is being evaluated in Phase 2 trials as a possible therapeutic intervention for those battling alcoholism. These exciting developments offer renewed optimism for improving outcomes and quality of life among individuals affected by this challenging condition.
What alcoholism clinical trials were recently completed?
Several recent clinical trials addressing alcoholism have achieved significant milestones, highlighting the ongoing efforts to combat this challenging condition. In December 2021, a trial sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) concluded its investigation into ASP8062. Similarly, in September 2021, Dicerna Pharmaceuticals completed their trial evaluating the potential of DCR-AUD as a treatment option. Additionally, Denver Health and Hospital Authority accomplished an Enhanced linkage study in January 2021. These advancements in research signify crucial steps towards understanding and developing effective interventions for individuals struggling with alcohol addiction.