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Trials for Ductal Carcinoma Patients
Hormone Therapy
Hormone Therapy + Immunotherapy for Advanced Breast Cancer
This trial is testing tamoxifen citrate or letrozole with or without bevacizumab to treat stage IIIB or IV breast cancer. Estrogen fuels breast cancer cell growth, so hormone therapy with tamoxifen or letrozole can block estrogen and stop tumor growth. Bevacizumab is an immunotherapy that may help the body's immune system fight the cancer. Researchers want to see if it is more effective with or without bevacizumab.
Poly (ADP-ribose) polymerase (PARP) inhibitor
Veliparib + Carboplatin for Breast Cancer
This trial is testing the combination of veliparib and carboplatin to treat patients with HER2-negative breast cancer that has spread. Veliparib may help carboplatin kill more cancer
Angiogenesis Inhibitor
Cediranib + Olaparib for Ovarian and Breast Cancer
This trial is testing the combination of two drugs, cediranib maleate and olaparib, to treat patients with certain types of recurrent cancer. Cediranib maleate cuts off the blood supply to cancer cells, while olaparib stops them from repairing their DNA. The trial aims to find the best dose and see if the combination works better than using olaparib by itself. Combining cediranib, which cuts off the blood supply to cancer cells, with olaparib, which stops cancer cells from repairing their DNA, may help patients live longer without their cancer getting worse.
Trials for Breast Cancer Patients
Hormone Therapy
Hormone Therapy + Immunotherapy for Advanced Breast Cancer
This trial is testing tamoxifen citrate or letrozole with or without bevacizumab to treat stage IIIB or IV breast cancer. Estrogen fuels breast cancer cell growth, so hormone therapy with tamoxifen or letrozole can block estrogen and stop tumor growth. Bevacizumab is an immunotherapy that may help the body's immune system fight the cancer. Researchers want to see if it is more effective with or without bevacizumab.
Poly (ADP-ribose) polymerase (PARP) inhibitor
Veliparib + Carboplatin for Breast Cancer
This trial is testing the combination of veliparib and carboplatin to treat patients with HER2-negative breast cancer that has spread. Veliparib may help carboplatin kill more cancer
Angiogenesis Inhibitor
Cediranib + Olaparib for Ovarian and Breast Cancer
This trial is testing the combination of two drugs, cediranib maleate and olaparib, to treat patients with certain types of recurrent cancer. Cediranib maleate cuts off the blood supply to cancer cells, while olaparib stops them from repairing their DNA. The trial aims to find the best dose and see if the combination works better than using olaparib by itself. Combining cediranib, which cuts off the blood supply to cancer cells, with olaparib, which stops cancer cells from repairing their DNA, may help patients live longer without their cancer getting worse.
Trials for ER Positive Patients
Hormone Therapy
Hormone Therapy + Immunotherapy for Advanced Breast Cancer
This trial is testing tamoxifen citrate or letrozole with or without bevacizumab to treat stage IIIB or IV breast cancer. Estrogen fuels breast cancer cell growth, so hormone therapy with tamoxifen or letrozole can block estrogen and stop tumor growth. Bevacizumab is an immunotherapy that may help the body's immune system fight the cancer. Researchers want to see if it is more effective with or without bevacizumab.
Poly (ADP-ribose) polymerase (PARP) inhibitor
Veliparib + Carboplatin for Breast Cancer
This trial is testing the combination of veliparib and carboplatin to treat patients with HER2-negative breast cancer that has spread. Veliparib may help carboplatin kill more cancer
Hormone Therapy
Fulvestrant + Anastrozole for Breast Cancer
This trial is testing whether neoadjuvant endocrine therapy with fulvestrant or the combination of anastrozole and fulvestrant is better than anastrozole when given before surgery to shrink the cancer and stop it from growing.
Phase 3 Trials
Alkylating agents
Chemotherapy +/− Bevacizumab for Ovarian Cancer
This trial is studying carboplatin, paclitaxel, and gemcitabine hydrochloride given together with or without bevacizumab after surgery to treat patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer.
Hormone Therapy
Hormone Therapy + Immunotherapy for Advanced Breast Cancer
This trial is testing tamoxifen citrate or letrozole with or without bevacizumab to treat stage IIIB or IV breast cancer. Estrogen fuels breast cancer cell growth, so hormone therapy with tamoxifen or letrozole can block estrogen and stop tumor growth. Bevacizumab is an immunotherapy that may help the body's immune system fight the cancer. Researchers want to see if it is more effective with or without bevacizumab.
Alkylating agents
Chemotherapy + Bevacizumab for Head and Neck Cancers
This trial is testing chemotherapy with or without bevacizumab to see how well it works in treating patients with head and neck squamous cell carcinoma that has come back or spread to other parts of the body.
Trials With No Placebo
Alkylating agents
Chemotherapy +/− Bevacizumab for Ovarian Cancer
This trial is studying carboplatin, paclitaxel, and gemcitabine hydrochloride given together with or without bevacizumab after surgery to treat patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer.
Microtubule Inhibitor
Eribulin Mesylate for Advanced Bladder Cancer
This trial looks at the effect of eribulin mesylate on patients with cancer of the urothelium that has spread to nearby tissue or to other places in the body and kidney dysfunction.
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Frequently Asked Questions
Introduction to basal cell carcinoma
What are the top hospitals conducting basal cell carcinoma research?
When it comes to advancing research and treatments for basal cell carcinoma, several leading hospitals are at the forefront of innovation. In Duarte, California, the City of Hope Comprehensive Cancer Center is making significant strides with 18 active clinical trials dedicated to this type of skin cancer. Although they have only recorded two all-time trials since their first in 2013, their commitment to finding new solutions is evident. Similarly, the University of California Davis Comprehensive Cancer Center in Sacramento has also embarked on 18 active basal cell carcinoma trials. With three all-time studies conducted since their initial trial in 2013, they are actively contributing to our understanding and management of this condition.
Houston's M D Anderson Cancer Center is another notable institution that has been instrumental in driving progress against basal cell carcinoma. They currently have an impressive number of 18 ongoing clinical trials for this condition and have completed three all-time trials after recording their first trial back in 2007.
In Burbank, California, Providence Saint Joseph Medical Center/Disney Family Cancer Center is focused on combating basal cell carcinoma through cutting-edge research with a remarkable count of seventeen active clinical trials. Despite having conducted just one previous study since commencing its inaugural trial in 2017, they continue to be a vital part of the fight against this form of skin cancer.
Lastly but not least important, USC / Norris Comprehensive Cancer Center located in Los Angeles joins this group with its dedication towards treating basal cell carcinoma by conducting sixteen current clinical tests while adding value by carrying out previous two experiments from starting it's pioneering investigation on such cases way back until1993- ensuring patients benefit from contemporary advancements made within recent years.
These esteemed hospitals are paving the way for improved outcomes and enhanced care options for those affected by basal cell carcinoma. Through relentless research efforts and collaborative initiatives across multiple locations nationwide as mentioned above; medical professionals continue striving towards better understanding & effective treatment strategies ultimately bringing hope into lives confronted by cancers.
Which are the best cities for basal cell carcinoma clinical trials?
When it comes to basal cell carcinoma clinical trials, several cities have emerged as leading hubs for research and development. Anchorage, Alaska takes the lead with an impressive 75 active trials exploring treatments like Bevacizumab, Tamoxifen Citrate, and Arm III (anastrozole and fulvestrant). Oakland, California closely follows with 74 ongoing studies focused on innovative approaches such as Bevacizumab, Trastuzumab, and Paclitaxel. Denver, Colorado is another prominent city in this field with 73 active trials investigating therapeutic options like Bevacizumab, Paclitaxel, and Therapeutic Conventional Surgery. These cities offer individuals facing basal cell carcinoma access to cutting-edge clinical trials that hold promise for improved treatment outcomes.
Which are the top treatments for basal cell carcinoma being explored in clinical trials?
Clinical trials for basal cell carcinoma are actively exploring various treatment options, with one standout contender being bevacizumab. This powerful drug is currently involved in seven active trials dedicated to combating this particular type of skin cancer. With its first listing in 2009, bevacizumab has already shown promise and potential as a potential game-changer in the fight against basal cell carcinoma. Researchers are diligently working towards uncovering new insights and breakthroughs that could revolutionize treatment approaches for patients facing this condition.
What are the most recent clinical trials for basal cell carcinoma?
Exciting advancements are being made in the field of basal cell carcinoma through recent clinical trials. One such trial is investigating the potential benefits of nicotinamide, a form of vitamin B3, for treating basal cell carcinoma. This Phase 3 trial became available on 8/28/2023 and holds promise for improving outcomes for patients with this type of skin cancer. Another trial worth noting is studying CX-4945 as a treatment option for basal cell carcinoma, which entered Phase 1 on 4/1/2019. These trials highlight the ongoing efforts to develop more effective treatments and enhance patient care in the fight against basal cell carcinoma
What basal cell carcinoma clinical trials were recently completed?
In the realm of basal cell carcinoma, several noteworthy clinical trials have recently concluded, showcasing promising developments in treatment options. Morphogenesis, Inc.'s trial investigating IFx-Hu2.0 reached completion in June 2021, providing valuable insights into its potential efficacy against this form of skin cancer. Similarly, Xencor, Inc.'s trial for XmAb20717 wrapped up in July 2018 and Regeneron Pharmaceuticals' study on cemiplimab was finalized back in June 2017. These significant milestones highlight the ongoing dedication to advancing therapeutic strategies for basal cell carcinoma patients and renew hope for improved outcomes.