Popular Trials
Stem Cell Transplant
Cord Blood Transplant for Blood Cancers and Diseases
This trial is for people who need cord blood transplants and best match cord blood units that are not FDA-licensed. Doctors will observe participants for up to a year after the transplant.
Behavioural Intervention
Multidisciplinary Health Intervention for Blood Cancer
This trial is studying a multidisciplinary intervention to help older adults with blood cancers who are planning a stem cell transplant. The intervention includes multiple healthcare professionals and is aimed at improving fitness and the ability to bounce back after transplant.
BMS-986158 + Ruxolitinib/Fedratinib for Myelofibrosis
This trial is testing a new drug called BMS-986158 for patients with high-risk blood cancer. It aims to see if the drug works better alone or when combined with existing treatments, Ruxolitinib and Fedratinib. Ruxolitinib is the first FDA-approved JAK inhibitor for myeloproliferative neoplasms, effective in controlling symptoms and improving splenomegaly, but many patients develop disease progression with long-term use.
Epigenetic Modulator
AZD4573 + Acalabrutinib for Blood Cancer
This trial tests a new drug, AZD4573, combined with another drug, acalabrutinib, for patients with certain blood cancers who haven't responded to other treatments. The drugs work together to kill cancer cells and block their growth. Acalabrutinib is more selective and has fewer side effects compared to an older drug.
Popular Filters
Trials for Acute Myelogenous Leukemia Patients
Alkylating agents
Donor Lymphocyte Infusion for Blood Cancers
This trial is testing if giving white blood cells from a donor to patients with high-risk blood cancers can reduce the risk of the cancer coming back. The goal is to see if this approach helps fight off remaining cancer cells and prevents relapse.
Alkylating agents
Reduced-Dose Cyclophosphamide for Blood Cancer
This trial is testing if a lower dose of cyclophosphamide after a bone marrow transplant can help adults with difficult-to-treat blood cancers. The aim is to prevent complications from donor cells attacking the body while reducing side effects. The study focuses on patients who are older, less fit, or have not had success with other treatments.
Trials for Acute Lymphoblastic Leukemia Patients
Alkylating agents
Donor Lymphocyte Infusion for Blood Cancers
This trial is testing if giving white blood cells from a donor to patients with high-risk blood cancers can reduce the risk of the cancer coming back. The goal is to see if this approach helps fight off remaining cancer cells and prevents relapse.
Alkylating agents
Reduced-Dose Cyclophosphamide for Blood Cancer
This trial is testing if a lower dose of cyclophosphamide after a bone marrow transplant can help adults with difficult-to-treat blood cancers. The aim is to prevent complications from donor cells attacking the body while reducing side effects. The study focuses on patients who are older, less fit, or have not had success with other treatments.
Cognitive Training for Post-Transplant Cognitive Impairment
This trial will test whether it is possible to enroll patients in a study to improve their thinking skills after they have had a hematopoietic cell transplant, as well as whether patients are interested in learning about their genetic risk for cognitive impairment after the transplant.
Trials With No Placebo
Alkylating agents
Donor Lymphocyte Infusion for Blood Cancers
This trial is testing if giving white blood cells from a donor to patients with high-risk blood cancers can reduce the risk of the cancer coming back. The goal is to see if this approach helps fight off remaining cancer cells and prevents relapse.
Alkylating agents
Reduced-Dose Cyclophosphamide for Blood Cancer
This trial is testing if a lower dose of cyclophosphamide after a bone marrow transplant can help adults with difficult-to-treat blood cancers. The aim is to prevent complications from donor cells attacking the body while reducing side effects. The study focuses on patients who are older, less fit, or have not had success with other treatments.
Frequently Asked Questions
Introduction to blood cancer
What are the top hospitals conducting blood cancer research?
When it comes to cutting-edge clinical trials in the field of blood cancer, several top hospitals have emerged as leaders. Memorial Sloan Kettering Cancer Center, located in New york City, is at the forefront with four ongoing blood cancer trials and an impressive track record of 35 completed studies since their first recorded trial in 2005. The National Institutes of Health Clinical Center in Bethesda also plays a significant role, conducting three active clinical trials focused on blood cancer and contributing to a total of 13 previous studies dating back to their inaugural trial in 2003.
In Boston, Massachusetts General Hospital has made notable contributions with three ongoing blood cancer trials and a history encompassing 19 prior investigations since initiating research on this condition back in 2002. Meanwhile, Tufts Medical Center boasts an equally commendable commitment with three current clinical tests for blood cancer and five previously conducted trials starting only recently in2011.
An additional institution making noteworthy strides is the City of Hope Medical Center situated in Duarte. Despite being smaller-scale by comparison when it comes to active trials or past endeavors both are dwarfed but its critical contribution lies within its three present-day investigations that hold promise for advancements against this complex disease; additionally adding value through eleven accomplished experiments from before whose humble origins date all the way back until1999.
These remarkable institutions across multiple locations serve as beacons of hope for those affected by various types of blood cancers. With each passing year and every new clinical trial conducted, researchers inch closer towards better understanding these diseases while developing innovative treatments that offer improved outcomes for patients around the world
Which are the best cities for blood cancer clinical trials?
When it comes to blood cancer clinical trials, several cities stand out as hotspots for research and development. Boston, Massachusetts leads the way with 9 active trials focusing on treatments like Enasidenib, BMS-986158, and TAK-981. New york, New York closely follows with 8 ongoing studies exploring therapies such as Enasidenib, CYNK-001, and Cord Blood Transplant. Duarte, California also joins the ranks with 8 active trials investigating treatment options like Enasidenib and AZD4573. Houston, Texas contributes to the field with 7 active trials studying interventions such as CYNK-001 and TAK-981. Finally, Bethesda in Maryland boasts 4 active trials examining treatments including Cyclophosphamide and Cord Blood Transplant. These cities offer individuals battling blood cancer access to cutting-edge clinical trials that have the potential to revolutionize care outcomes.
Which are the top treatments for blood cancer being explored in clinical trials?
The world of blood cancer research is abuzz with promising treatments currently being explored in clinical trials. Two top contenders include cyclophosphamide and cord blood transplant. Cyclophosphamide, first listed in 2000, has been involved in two active trials and an impressive 57 all-time blood cancer trials. Cord blood transplant, on the other hand, made its debut in 2012 and has since gained traction with two ongoing trials and one all-time trial dedicated to battling this complex disease. Another noteworthy treatment making waves is tranexamic acid—a newcomer that entered the scene in 2016—and has shown potential through one active trial and involvement in two previous studies focused on combating blood cancer. As researchers continue their efforts towards finding effective solutions for patients worldwide, these treatments offer glimpses of hope on the horizon.
What are the most recent clinical trials for blood cancer?
Exciting advancements are being made in the field of blood cancer research through recent clinical trials. One notable trial is exploring the potential of cord blood transplant as a treatment option for patients with blood cancer, showing promising results in phase 2. Another study focuses on dose escalation and matching techniques, aiming to optimize treatment outcomes for individuals with this challenging disease. Additionally, tranexamic acid has shown promise in phase 3 trials as a potential therapeutic intervention. Moreover, ongoing investigations into drugs like fedratinib and LOXO-338 hold great potential for improving patient care and survival rates in the future. These cutting-edge studies shed light on new pathways towards effective treatments against various types of blood cancers.
What blood cancer clinical trials were recently completed?
In recent years, multiple clinical trials have been completed for various blood cancers, showcasing the dedicated efforts of researchers in advancing treatment options. Notably, a trial sponsored by the National Cancer Institute (NCI) concluded in April 2021 and explored the potential of mRNA-1273 therapy. Similarly, Prelude Therapeutics conducted a trial on PRT1419 that ended in September 2020. Additionally, Epizyme's investigation into Tazemetostat was completed in April 2020. These studies contribute to our evolving understanding of blood cancer treatments and offer hope for patients grappling with these challenging diseases.