Glioblastoma Clinical Trials in Cincinnati, OH

View the best 10 glioblastoma medical studies in Cincinnati, Ohio. Access promising new therapies by applying to a Cincinnati-based Glioblastoma clinical trial.

Trials in Cincinnati, Ohio

Here are the top 10 medical studies for glioblastoma in Cincinnati, Ohio

Lorlatinib

ALK Inhibitor

Recruiting1 awardPhase < 1

This trial aims to see how well the drug loratinib works in treating children with a specific type of brain tumor called high-grade glioma. The study will also look at the safety of using lor

Cemiplimab +1 More

Monoclonal Antibodies

Recruiting1 awardPhase 1

This trial is testing the safety and effectiveness of combining two drugs, ASP8374 and cemiplimab, for people with recurrent brain cancer. The study aims to find the best dose and see if the combination helps before surgery. The drugs work by boosting the immune system to fight cancer cells. Cemiplimab has been previously tested in combination with other treatments for severe cancers.

SurVaxM

Cancer Vaccine

Recruiting1 awardPhase 1

This trial tests the SurVaxM vaccine, which helps the immune system target and destroy cancer cells, in children and young adults with certain difficult-to-treat brain cancers. The vaccine works by teaching the immune system to recognize a protein found in cancer cells. Additional substances are used to make the immune response stronger.

GammaTile radiation therapy implantation +3 More

Brachytherapy

Recruiting3 awardsPhase 4

This trial tests if adding GammaTile radiation therapy to standard treatment can improve outcomes for patients with newly diagnosed GBM. GammaTile delivers quick, direct radiation to the tumor, which may help control the tumor better and improve survival rates.

Selinexor +1 More

Selective Inhibitor of Nuclear Export

Recruiting1 awardPhase 1 & 2

This trial tests selinexor with temozolomide for patients whose brain cancer has returned. Selinexor blocks a protein that helps cancer cells grow, and temozolomide damages their DNA to kill them or stop their growth. Temozolomide is a DNA methylating drug currently used as a first-line treatment in glioblastoma therapy.

Temozolomide +1 More

Chemotherapy

Recruiting1 awardPhase 3

This trial is testing a treatment for newly diagnosed brain cancer patients. They are comparing the effectiveness of a new treatment called Optune with chemotherapy and immunotherapy to a combination of Optune with chemotherapy alone.

Temozolomide +1 More

Alkylating agents

Recruiting1 awardPhase 2

This trial is testing a new drug called OKN-007 combined with a chemotherapy drug, temozolomide, in patients whose brain cancer has returned after standard treatments. OKN-007 may help reduce tumor growth and make the chemotherapy more effective. Temozolomide is effective in treating malignant brain tumors.

LP-184

Recruiting1 awardPhase 1 & 2

This trial will measure how safe and tolerable a drug is and test its effectiveness in treating advanced solid tumors.

Photon Beam Radiation Therapy +2 More

Radiation Therapy

Recruiting1 awardPhase 2

This trial is studying how well two types of radiation therapy work compared to standard radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma.

Autologous genetically modified gamma-delta T cells +1 More

CAR T-cell Therapy

Recruiting1 awardPhase 1 & 2

This trial tests if a cell therapy can delay cancer return in GBM patients when combined with standard chemo. If it works, it should be studied further.

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Trials With No Placebo

ALK Inhibitor

Lorlatinib for Brain Tumors

Recruiting1 awardPhase < 1

Cincinnati, Ohio

This trial aims to see how well the drug loratinib works in treating children with a specific type of brain tumor called high-grade glioma. The study will also look at the safety of using lor

Alkylating agent

Olutasidenib + Temozolomide for Brain Tumors

Recruiting1 awardPhase 2

Cincinnati, Ohio

This trial will test if a drug can extend the life of kids/young adults with a deadly brain tumor linked to a genetic mutation.

LP-184 for Solid Tumors

Recruiting1 awardPhase 1 & 2

Louisville, Kentucky

This trial will measure how safe and tolerable a drug is and test its effectiveness in treating advanced solid tumors.

Chemotherapy

Ultrasound-Assisted Chemotherapy for Glioblastoma

Recruiting2 awardsPhase 3

Indianapolis, Indiana

This trial tests a new method to treat recurrent brain cancer using an ultrasound device called SonoCloud-9. The device helps open the brain's protective barrier so that more of the chemotherapy drug carboplatin can reach the tumor. The goal is to see if this combination makes the treatment more effective. Carboplatin has been used in various studies for treating high-grade gliomas and glioblastomas, often showing modest efficacy due to low tissue concentration when delivered intravenously.

mTOR Inhibitor

Ribociclib + Everolimus for Brain Tumors

Recruiting1 awardPhase 2

Cincinnati, Ohio

This trial is testing whether the combination of ribociclib and everolimus can help children and young adults with aggressive brain tumors live longer. Everolimus is a medication that has been approved for treating various cancers. These drugs are taken by mouth and work by stopping cancer cells from growing. The study focuses on patients whose tumors have specific genetic changes that make them hard to treat with standard therapies.

CAR T-cell Therapy

Gene-Modified T Cell Therapy for Glioblastoma

Recruiting1 awardPhase 1 & 2

Louisville, Kentucky

This trial tests if a cell therapy can delay cancer return in GBM patients when combined with standard chemo. If it works, it should be studied further.

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Frequently Asked Questions

Do I need insurance to participate in a trial?

Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).

Is there any support for travel costs?

Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.

Will I know what medication I am taking?

This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.

How long do clinical trials last?

Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.

Do you verify all the trials on your website?

All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.

How quickly will I hear back from a clinical trial?

Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.