Popular Trials
Behavioural Intervention
Osteopathic Manipulative Treatment for Headaches
This trial aims to investigate if osteopathic manipulation or light touch can help reduce the frequency of headaches and the use of pain medication. They will compare the effects of a specific osteopathic treatment with a light
Popular Filters
Trials for Migraine Patients
Psychedelic Therapy
Psilocybin for Headaches
"This trial aims to understand why psilocybin can reduce headaches by studying brain activity, synaptic density, inflammation markers, circadian rhythm, and sleep patterns before and after administering psilocybin or
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Trials for MA Patients
Psychedelic Therapy
Psilocybin for Headaches
"This trial aims to understand why psilocybin can reduce headaches by studying brain activity, synaptic density, inflammation markers, circadian rhythm, and sleep patterns before and after administering psilocybin or
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Trials With No Placebo
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Behavioural Intervention
Nerivio Device for New Daily Persistent Headache
This trial tests a wearable device that sends mild electrical pulses to help reduce headache pain in adolescents aged 12-17 with persistent headaches. The device is controlled by a smartphone app and works by triggering the brain's natural pain relief mechanisms. Data from several trials suggest that a device applying gentle electrical pulses can reduce headache pain.
Frequently Asked Questions
Introduction to chronic daily headache
What are the top hospitals conducting chronic daily headache research?
When it comes to advancing the understanding and treatment of chronic daily headache, several top hospitals are leading the way. In Aurora, Colorado, the University of Colorado and Children's Hospital Colorado are actively conducting two clinical trials focused on this debilitating condition. This collaboration between esteemed institutions is only part of their significant dedication to chronic daily headache research, having recorded a total of two trials since their pioneering study in 2021. Meanwhile, in Cincinnati, Ohio, Cincinnati Children's Hospital Medical Center has also emerged as a prominent player in this field with two ongoing chronic daily headache trials. Their commitment to finding solutions for these persistent headaches dates back to their first trial in 2021.
In Birmingham, Alabama, the University of Alabama at Birmingham Children's of Alabama is making notable strides with one active clinical trial centered around chronic daily headaches. Despite being relatively new to conducting such investigations (having started just recently in 2023), this hospital demonstrates its commitment to improving the lives of those suffering from this condition through rigorous research efforts. Similarly, Phoenix Children's Hospital - Barrow Neurological Institute in Phoenix joins this effort by initiating their own first-ever chronic daily headache trial also beginning in 2023.
Last but not least among these top hospitals is the University of California San Francisco located right within vibrant San Francisco itself where they have been reported running similar experimental tests very recently focusing on investigating potential ways treating patients affected by these severe headachings.Their journey began likewise from 2023 marking remarkable contribution towards combatting challenges posed by Chronic Daily Headaches.
These healthcare institutions stand as beacons for individuals struggling with chronic daily headaches—offering hope through scientific exploration and cutting-edge treatments that aim to provide relief and ultimately lead them towards living pain-free lives
Which are the best cities for chronic daily headache clinical trials?
When it comes to chronic daily headache clinical trials, several cities have emerged as key players in conducting research and finding effective treatments. Cincinnati, Ohio takes the lead with 3 ongoing trials focusing on cognitive-behavioral therapy (CBT) combined with clinically-prescribed prevention therapies like amitriptyline. Aurora, Colorado follows closely behind with 2 active trials exploring similar approaches. Philadelphia, Pennsylvania and Memphis, Tennessee also contribute significantly to this field with their respective studies on CBT paired with amitriptyline and other interventions. Lastly, Toronto in Ontario showcases its commitment to innovative solutions through 2 ongoing trials investigating alternative treatments such as cannabidiol-enriched cannabis herbal extract and ketamine infusion. These cities provide valuable opportunities for individuals suffering from chronic daily headaches to participate in groundbreaking clinical trials that may lead to improved management strategies and relief.
Which are the top treatments for chronic daily headache being explored in clinical trials?
The search for effective treatments for chronic daily headache is ongoing, with one particular treatment showing promise in clinical trials. The sphenopalatine ganglion block with 0.5% bupivacaine has gained attention and is currently being explored in one active trial specifically for chronic daily headaches. This novel treatment option was first listed in 2022 and represents a potential breakthrough in managing this debilitating condition. As researchers delve deeper into understanding the mechanisms behind chronic daily headaches, they strive to uncover more solutions that can provide relief and improve the quality of life for those affected by this condition.
What are the most recent clinical trials for chronic daily headache?
Recent clinical trials offer hope and potential breakthroughs in the treatment of chronic daily headache. Among these trials, a Phase 1 study explored the use of a cannabidiol-enriched cannabis herbal extract to alleviate symptoms. Additionally, a Phase 3 trial investigated the efficacy of ketamine infusion for chronic daily headache patients. Another study focused on paracervical injection as a potential treatment option during Phase 2 trials. Furthermore, SPN-538 underwent Phase 4 testing to assess its effectiveness against chronic daily headaches. Lastly, a Phase 3 trial evaluated the benefits of combining headache education with amitriptyline for this condition. These ongoing studies bring optimism to those suffering from chronic daily headaches by offering new avenues for relief and management strategies
What chronic daily headache clinical trials were recently completed?
Several clinical trials investigating chronic daily headaches have recently concluded, bringing new insights into potential treatments for this debilitating condition. Most notably, a trial led by the University of California San Francisco was completed in May 2021 and focused on evaluating the efficacy of a novel medication. Additionally, researchers at Johns Hopkins University wrapped up a study in March 2021 that explored non-pharmacological interventions for chronic daily headaches. These recent advancements highlight the ongoing commitment to improving our understanding and management of this distressing form of headache disorder.