Trials in Philadelphia, Pennsylvania
Here are the top 10 medical studies for depression in Philadelphia, Pennsylvania
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Phase 3 Trials
Aticaprant for Depression
Recruiting1 awardPhase 3
Allentown, Pennsylvania
This trial is testing aticaprant to see if it can help adults with major depressive disorder and anhedonia who haven't responded well to other antidepressants. Aticaprant works by blocking certain receptors in the brain to potentially improve depressive symptoms.
Psychedelic
Psilocybin for Treatment-Resistant Depression
Recruiting1 awardPhase 3
Toms River, New Jersey
This trial is testing a new medication called COMP360 to help people with severe depression that hasn't improved with other treatments. The study involves adults aged 18 and older. Researchers want to see if a single dose of COMP360 can reduce depression symptoms when given with psychological support.
Lumateperone for Major Depressive Disorder
Recruiting1 awardPhase 3
Philadelphia, Pennsylvania
This trial is testing lumateperone, a medication that may help people with depression who haven't improved with other treatments. The study includes patients diagnosed with Major Depressive Disorder who haven't responded well to their current antidepressants. Lumateperone works by balancing brain chemicals that affect mood, potentially improving depressive symptoms.
NMRA-335140 for Depression
Recruiting2 awardsPhase 3
Media, Pennsylvania
This trial is testing a new medication called NMRA-335140 to see if it helps people with major depressive disorder. It includes participants who have no safety concerns. The medication aims to improve mood by affecting brain chemicals.
Behavioural Intervention
NMRA 335140 for Depression
Recruiting1 awardPhase 3
Media, Pennsylvania
This trial is testing a new medication called NMRA 335140 to see if it can help people with Major Depressive Disorder feel less depressed. The study involves an initial evaluation and a treatment phase where participants will receive either the medication or an inactive substance. The medication likely works by changing brain chemicals that affect mood.
Trials With No Placebo
Behavioural Intervention
Mindfulness-Based Neurofeedback for Depression
Recruiting1 award
New York, New York
This trial uses real-time brain scans to help depressed adolescents practice mindfulness and control their brain activity. It targets teens with major depression who don't respond well to current treatments. By seeing their brain activity live, they can reduce negative thinking patterns that worsen depression.
Psychotherapy
Psychotherapy for Postpartum Depression
Recruiting1 award6 criteria
New York, New York
This trial tests a remote therapy called Engage & Connect for new mothers with postpartum depression. The therapy aims to reduce depression by encouraging social activities with significant others, helping mothers feel happier and less isolated.
Behavioral Intervention
Mindfulness Therapy for Migraines
Recruiting1 award
Bronx, New York
This trial is testing a type of therapy called Mindfulness-Based Cognitive Therapy, provided over the phone, through video calls, or as part of regular care with added support. It aims to help people with migraines and depressive symptoms by teaching them to focus on the present moment and understand their thought patterns better. Mindfulness-Based Cognitive Therapy (MBCT) was developed to prevent relapse in recurrent depression by combining cognitive behavioral therapy and meditative techniques.
Behavioural Intervention
Behavioral Activation for Depression
Recruiting1 awardPhase 2
New York, New York
This trial is testing if a type of therapy called behavioral activation, which helps people do enjoyable activities to feel better, can be done over the phone or video calls. It focuses on older adults who have survived cancer and are dealing with depression. Behavioral activation is a well-established treatment for depression, recognized for its effectiveness in increasing engagement in enjoyable activities to improve mood.
Photobiomodulation
Transcranial Photobiomodulation for Depression
Recruiting1 award3 criteria
New York, New York
This trial is testing a special kind of invisible light aimed at the forehead to help people with depression. The light might improve blood flow in the brain. About 60 people with depression will be part of this study to see if this treatment works.
SGLT2 Inhibitor
SGLT2 Inhibitor for Depression
Recruiting1 awardPhase 2
New York, New York
This trial is testing whether empagliflozin, a medication that helps produce ketone bodies, can reduce depression symptoms. It targets people with depression by providing an alternative energy source for the brain, potentially improving their mood.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.