Anti-tumor antibiotic
Utidelone + Capecitabine for Breast Cancer with Brain Metastases
Recruiting1 awardPhase 2
Oxnard, California
This trial aims to test the effectiveness and safety of using utidelone along with capecitabine to treat patients with HER2-negative breast cancer that has spread to the brain. Patients will receive
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Trials for Diffuse Intrinsic Pontine Glioma Patients
Chemotherapy
PF-07799544 for Cancer
Recruiting1 awardPhase 1
Fayetteville, Arkansas
This trial tests a new cancer medicine, PF-07799544, taken regularly as a tablet. It is for people with advanced solid tumors who haven't responded to other treatments. The medicine may be used alone or with other drugs to improve its effectiveness.
CDK4/6 Inhibitor
Abemaciclib + Elacestrant for Brain Metastasis from Breast Cancer
Recruiting1 awardPhase 1 & 2
Canton, Ohio
This trial tests a combination of two drugs, elacestrant and abemaciclib, in patients with a specific type of breast cancer. It aims to find the best dose and see how well it works for those whose cancer has spread to the brain. The drugs work by blocking signals that help cancer cells grow and divide. Abemaciclib is a drug that has been approved for the treatment of certain advanced breast cancers.
Trials for Pituitary Adenomas Patients
Chemotherapy
PF-07799544 for Cancer
Recruiting1 awardPhase 1
Fayetteville, Arkansas
This trial tests a new cancer medicine, PF-07799544, taken regularly as a tablet. It is for people with advanced solid tumors who haven't responded to other treatments. The medicine may be used alone or with other drugs to improve its effectiveness.
CDK4/6 Inhibitor
Abemaciclib + Elacestrant for Brain Metastasis from Breast Cancer
Recruiting1 awardPhase 1 & 2
Canton, Ohio
This trial tests a combination of two drugs, elacestrant and abemaciclib, in patients with a specific type of breast cancer. It aims to find the best dose and see how well it works for those whose cancer has spread to the brain. The drugs work by blocking signals that help cancer cells grow and divide. Abemaciclib is a drug that has been approved for the treatment of certain advanced breast cancers.
Trials for HER2 Positive Patients
Diagnostic Test
MRI Screening for Brain Metastases in Breast Cancer
Recruiting1 award3 criteria
Toronto, Ontario
This trial will recruit 50 women with metastatic breast cancer to study the benefits of routine MRI screening for brain metastases. The participants will be randomly assigned to receive either regular brain MRI screening or the
Antimetabolite
Neratinib + Capecitabine for Breast Cancer
Recruiting1 awardPhase 2
Rochester, New York
This trial is testing a combination of neratinib and capecitabine for breast cancer patients with brain metastases. These patients' tumors did not show HER2 activity with usual tests but did with a special test, suggesting they might benefit from this treatment. Neratinib blocks growth proteins in cancer cells, while capecitabine kills them. Neratinib is approved for use in combination with capecitabine for advanced HER2-positive breast cancer.
Phase 3 Trials
Radiation Therapy
Radiosurgery vs Whole Brain Radiation for Brain Metastasis
Recruiting2 awardsPhase 3
Houston, Texas
This trial compares two radiation treatments for brain tumors from non-melanoma cancers. One treatment is a focused, high-dose method, while the other treats the entire brain over several sessions. The goal is to determine which method controls tumors better and has fewer side effects on thinking and memory. The focused, high-dose method has been increasingly used over the past years as an effective treatment for brain metastases, often replacing the whole brain treatment due to its ability to improve outcomes and reduce side effects.
Radiation
Stereotactic Radiosurgery vs. HA-WBRT + Memantine for Brain Cancer
Recruiting2 awardsPhase 3
Tucson, Arizona
This trial is testing whether memantine used in combination with HA-WBRT helps to improve mental function (measured by how well patients can remember things) compared to those who receive HA-WBRT alone.
Procedure
Surgery and Radiation vs. Radiation Alone for Brain Cancer
Recruiting2 awardsPhase 3
Decatur, Illinois
This trialcompares two treatments to help stop cancer spread to the brain: surgery w/ radiation therapy or radiation therapy alone. Radiation is targeted to cancer cells while avoiding healthy brain tissue.
Trials With No Placebo
Chemotherapy
PF-07799544 for Cancer
Recruiting1 awardPhase 1
Fayetteville, Arkansas
This trial tests a new cancer medicine, PF-07799544, taken regularly as a tablet. It is for people with advanced solid tumors who haven't responded to other treatments. The medicine may be used alone or with other drugs to improve its effectiveness.
CDK4/6 Inhibitor
Abemaciclib + Elacestrant for Brain Metastasis from Breast Cancer
Recruiting1 awardPhase 1 & 2
Canton, Ohio
This trial tests a combination of two drugs, elacestrant and abemaciclib, in patients with a specific type of breast cancer. It aims to find the best dose and see how well it works for those whose cancer has spread to the brain. The drugs work by blocking signals that help cancer cells grow and divide. Abemaciclib is a drug that has been approved for the treatment of certain advanced breast cancers.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.