Contrast Agent
AMRI vs. Ultrasound for Liver Cancer Surveillance
Recruiting3 awardsPhase 4
La Jolla, California
This trial compares the use of gadolinium contrast-enhanced Abbreviated MRI (AMRI) to standard ultrasound for the screening and surveillance of subjects with liver cirrhosis who are at risk for developing hepatocellular carcinoma (HCC).
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Trials for Myelofibrosis Patients
Anti-metabolite
Ruxolitinib + Azacytidine for Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm
Recruiting1 awardPhase 2
Houston, Texas
This trial is testing two drugs, ruxolitinib phosphate and azacytidine, in patients with specific types of blood cancers that are hard to treat. Ruxolitinib blocks enzymes needed for cancer cell growth, while azacytidine kills cancer cells or stops them from dividing. Azacytidine is a well-known anticancer drug used in the treatment of various cancers, including breast cancer, melanoma, and colon cancer. The goal is to find a more effective treatment for these patients.
Anti-metabolites
Decitabine for Myelofibrosis
Recruiting1 awardPhase 2
Chicago, Illinois
This trial looks at the side effects and effectiveness of decitabine in treating patients with myelofibrosis, a cancer of the blood system. Decitabine may block proteins that turn certain genes off in various cancers including myelofibrosis.
Small Molecule Inhibitor
KRT-232 for Myelofibrosis
Recruiting1 awardPhase 2 & 3
Birmingham, Alabama
This trial will study KRT-232, a new drug that inhibits MDM2, for the treatment of patients with myelofibrosis who are no longer benefiting from treatment with a JAK inhibitor. The trial will be conducted in 2 phases.
Trials for Cystic Fibrosis Patients
Monoclonal Antibodies
Denosumab for Osteoporosis in Cystic Fibrosis
Recruiting3 awardsPhase 4
Dallas, Texas
This trial is testing a new way to treat CF patients with bone disease. Up to 100 subjects with CF will participate in a single study visit that will include a DEXA scan, micro CT, and blood collection. If results indicate bone disease, subjects will receive treatment with Denosumab for up to 5 years.
Cephalosporin Antibiotic
Ceftaroline for Cystic Fibrosis
Recruiting3 awardsPhase 4
Cincinnati, Ohio
This trial is testing a new way to give the antibiotic ceftaroline to kids with cystic fibrosis who also have a history of methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant Staphylococcus aureus (ORSA).
Angiotensin II Receptor Blocker
Losartan for Cystic Fibrosis
Recruiting1 awardPhase < 1
Kansas City, Kansas
This trial is testing losartan, a blood pressure medication, to see if it can help clear mucus from the lungs of cystic fibrosis patients who can't use current treatments. These patients need alternative treatments because they don't respond to existing options. Losartan may reduce lung inflammation, making it easier for them to breathe.
GLP-1 Agonist
GLP-1 Agonist Therapy for Cystic Fibrosis-related Diabetes
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial looks at whether a weekly injection of a medication called dulaglutide can help improve early-phase insulin secretion and glucose tolerance in people with cystic fibrosis-related diabetes.
Hormone Therapy
CGM-Assisted Insulin Dosing for Cystic Fibrosis-Related Diabetes
Recruiting3 awardsPhase 4
Pittsburgh, Pennsylvania
This trial is testing whether using a CGM to help calculate meal-time insulin doses leads to better blood sugar management for people with CF than the current standard method.
Trials for CFTR Positive Patients
Angiotensin II Receptor Blocker
Losartan for Cystic Fibrosis
Recruiting1 awardPhase < 1
Kansas City, Kansas
This trial is testing losartan, a blood pressure medication, to see if it can help clear mucus from the lungs of cystic fibrosis patients who can't use current treatments. These patients need alternative treatments because they don't respond to existing options. Losartan may reduce lung inflammation, making it easier for them to breathe.
GLP-1 Agonist
GLP-1 Agonist Therapy for Cystic Fibrosis-related Diabetes
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial looks at whether a weekly injection of a medication called dulaglutide can help improve early-phase insulin secretion and glucose tolerance in people with cystic fibrosis-related diabetes.
Gene Therapy
Gene Therapy (4D-710) for Cystic Fibrosis
Recruiting1 awardPhase 1 & 2
Kansas City, Kansas
This trial is testing a new gene therapy called 4D-710 in adults with cystic fibrosis who can't use standard treatments. The goal is to see if it is safe and effective. 4D-710 is part of a new generation of AAV vectors being developed for cystic fibrosis gene therapy.
Phase 3 Trials
Statin
Simvastatin for Liver Cirrhosis
Recruiting1 awardPhase 3
San Francisco, California
This trial tests if simvastatin can prevent serious liver problems in U.S. Veterans with early-stage liver damage. Simvastatin not only lowers cholesterol but also helps protect the liver from further damage and reduces the risk of severe liver issues. Statins, including simvastatin, have been increasingly recognized for their potential benefits in treating chronic liver diseases, including cirrhosis, by reducing portal pressure and protecting against liver damage.
N-acetyl Cysteine for Idiopathic Pulmonary Fibrosis
Recruiting1 awardPhase 3
Stanford, California
This trial will compare the effect of NAC plus standard care with placebo plus standard of care in patients with idiopathic pulmonary fibrosis who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative decline in lung function, first respiratory hospitalization, lung transplantation, or all-cause mortality.
Resmetirom for Fatty Liver Disease
Recruiting1 awardPhase 3
Chandler, Arizona
This trial is testing a medication called MGL-3196 to see if it can help treat patients with NASH and liver fibrosis. The medication works by reducing fat and inflammation in the liver, which can help heal and protect it from further damage.
Trials With No Placebo
Monoclonal Antibodies
Denosumab for Osteoporosis in Cystic Fibrosis
Recruiting3 awardsPhase 4
Dallas, Texas
This trial is testing a new way to treat CF patients with bone disease. Up to 100 subjects with CF will participate in a single study visit that will include a DEXA scan, micro CT, and blood collection. If results indicate bone disease, subjects will receive treatment with Denosumab for up to 5 years.
Cephalosporin Antibiotic
Ceftaroline for Cystic Fibrosis
Recruiting3 awardsPhase 4
Cincinnati, Ohio
This trial is testing a new way to give the antibiotic ceftaroline to kids with cystic fibrosis who also have a history of methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant Staphylococcus aureus (ORSA).
Behavioural Intervention
Manual Therapy for Swallowing Difficulty in Head and Neck Cancer Survivors
Recruiting1 award3 criteria
Houston, Texas
This trial studies the effectiveness of manual therapy (massage and stretching exercises) in treating fibrosis-related dysphagia (difficulty swallowing) in survivors of head and neck cancer.
Angiotensin II Receptor Blocker
Losartan for Cystic Fibrosis
Recruiting1 awardPhase < 1
Kansas City, Kansas
This trial is testing losartan, a blood pressure medication, to see if it can help clear mucus from the lungs of cystic fibrosis patients who can't use current treatments. These patients need alternative treatments because they don't respond to existing options. Losartan may reduce lung inflammation, making it easier for them to breathe.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.