Behavioral Intervention
Neurofeedback for Depression
Recruiting0 awards
Tulsa, Oklahoma
This trial aims to investigate the relationship between brain connectivity and repetitive negative thinking in individuals with depression. The researchers will use a technique called real-time fMRI neurofeedback to reduce the connectivity between certain brain regions
Popular Filters
Trials for Depression Patients
Procedure
Individualized TMS for Depression
Recruiting1 awardPhase 2
Boston, Massachusetts
This trial tests aiTBS, a magnetic brain stimulation method, on patients with depression that hasn't responded to other treatments. The treatment uses magnetic pulses to reset brain activity and improve mood. Participants will receive aiTBS either guided by brain scans or by physical measurements of the head. Intermittent Theta Burst Stimulation (iTBS) is a newer form of repetitive Transcranial Magnetic Stimulation (rTMS) that has shown potential for faster and more intense effects in treating depression.
tDCS for Major Depressive Disorder
Recruiting0 awards2 criteria
Edmonton, Alberta
This trial tests tDCS, a non-invasive brain stimulation technique, on patients with severe depression who haven't responded to multiple treatments. The goal is to see if tDCS can help improve their mood by using a small electrical current to stimulate specific brain areas. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been investigated for its potential to treat depression, especially in patients who do not respond well to medication.
Procedure
Theta Burst Stimulation for Adolescent Depression
Recruiting1 award4 criteria
Ottawa, Ontario
This trial aims to study the effectiveness of a new treatment called Theta burst stimulation (TBS) for major depression in adolescents. They want to compare how well a new accelerated, three times a day T
Behavioural Intervention
Electrical Nerve Stimulation for Depression
Recruiting0 awards3 criteria
San Diego, California
This trial aims to test the effectiveness of a non-invasive treatment called Electrical Vestibular Nerve Stimulation (VeNS) for Major Depressive Disorder (MDD). Participants will be randomly assigned
Trials for Persistent Depressive Disorder Patients
NMDA Receptor Antagonist
Ketamine for Treatment-Resistant Depression
Recruiting1 awardPhase 2
Iowa City, Iowa
This trial is testing whether the antidepressant effects of ketamine are greater in people with a family history of alcohol use disorder, who may respond differently to both alcohol and ketamine.
Omega-3 Fatty Acids
Vitamin D + Omega-3 for Depression
Recruiting0 awards
Boston, Massachusetts
This trial is studying whether taking vitamin D3 or omega-3 fatty acids supplements reduces the risk of developing cancer, heart disease, and stroke. This study will also examine whether either of these supplements reduces the risk of clinical depression or improves mood scores over time.
Selective Serotonin Reuptake Inhibitor
Fluoxetine for Anxiety and Depression
Recruiting0 awardsPhase 2
Bethesda, Maryland
This trial uses fMRI to study brain regions engaged in processing motivationally salient stimuli in children, adolescents, and adults with mood and anxiety disorders, in order to better understand how these disorders develop and how they can be treated.
Phase 3 Trials
Aticaprant for Depression
Recruiting1 awardPhase 3
Colorado Springs, Colorado
This trial is testing aticaprant to see if it can help adults with major depressive disorder and anhedonia who haven't responded well to other antidepressants. Aticaprant works by blocking certain receptors in the brain to potentially improve depressive symptoms.
Psychedelic Therapy
Psilocybin for Depression
Recruiting1 awardPhase 3
Denver, Colorado
This trial is testing psilocybin, a substance from mushrooms, to see if it can help adults with depression who may not respond well to current treatments. Psilocybin works by affecting brain chemicals related to mood. Psilocybin has shown promise as a treatment for major depressive disorder and was designated as a breakthrough therapy by the FDA in 2019.
Aticaprant + Antidepressant for Depression
Recruiting1 awardPhase 3
Chicago, Illinois
This trial aims to see if aticaprant is effective in preventing the return of depression symptoms when added to antidepressant therapy in individuals with major depressive disorder who have already responded well to aticaprant treatment
Trials With No Placebo
Procedure
Individualized TMS for Depression
Recruiting1 awardPhase 2
Boston, Massachusetts
This trial tests aiTBS, a magnetic brain stimulation method, on patients with depression that hasn't responded to other treatments. The treatment uses magnetic pulses to reset brain activity and improve mood. Participants will receive aiTBS either guided by brain scans or by physical measurements of the head. Intermittent Theta Burst Stimulation (iTBS) is a newer form of repetitive Transcranial Magnetic Stimulation (rTMS) that has shown potential for faster and more intense effects in treating depression.
Behavioral Intervention
Social-Cognitive Skills Training for Schizophrenia
Recruiting1 award
Minneapolis, Minnesota
This trial will adapt an evidence-based social cognitive skills intervention for use with Veterans in a work setting, in order to help them better understand and manage social interactions.
Procedure
Theta Burst Stimulation for Adolescent Depression
Recruiting1 award4 criteria
Ottawa, Ontario
This trial aims to study the effectiveness of a new treatment called Theta burst stimulation (TBS) for major depression in adolescents. They want to compare how well a new accelerated, three times a day T
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.