Behavioral Intervention
Acceptance and Commitment Therapy for Chronic Migraine
Recruiting1 award
Boston, Massachusetts
This trial aims to see if a type of therapy called Acceptance and Commitment Therapy (ACT) can help improve daily functioning and reduce headaches in adults with chronic migraines. Participants will either receive ACT
Corticosteroid
Lidocaine + Steroid Injections for Migraines
Recruiting1 awardPhase 2
Camden, New Jersey
This trial aims to investigate if injecting lidocaine and steroids into two blood vessels in the brain can help treat chronic migraines. The study will assess the safety and effectiveness of this treatment for chronic migraine
Procedure
Intravenous Fluids for Childhood Migraine
Recruiting0 awards
Dayton, Ohio
This trial is comparing different amounts of fluids given through an IV to children with migraines. The trial wants to find out if giving a large amount of fluids quickly can help reduce pain and prevent hospital admissions
Behavioural Intervention
High-Fat Meal Effects on Cardiovascular Risk in Women with Migraine
Recruiting1 award
Philadelphia, Pennsylvania
This trial is testing the effects of a high-fat, high-carbohydrate meal on various cardiovascular disease risk factors in young women with and without migraine, comparing obese and normal weight women in each group.
Behavioural Intervention
Auricular Acupuncture for Migraines
Recruiting3 awards1 criteria
Louisville, Kentucky
This trial compares ear acupuncture and standard IV medications for treating migraines in children in the emergency room. Ear acupuncture uses needles in the ear to change nerve signals and reduce pain, while standard treatments use drugs to relieve symptoms.
Calcitonin Gene-Related Peptide (CGRP) Antagonist
Atogepant for Migraine Prevention
Recruiting2 awardsPhase 3
Phoenix, Arizona
This trial is testing a medication called Atogepant to see if it can safely and effectively prevent migraines in people who have them often. The medication works by blocking signals in the brain that cause migraines. Atogepant is a newly approved oral medication for the prevention of episodic migraine.
Popular Filters
Trials for MA Patients
Behavioral Intervention
CBT + Amitriptyline for Childhood Migraine
Recruiting1 award4 criteria
Birmingham, Alabama
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Emotional Awareness and Expression Therapy for Migraine
Recruiting1 award
Salt Lake City, Utah
This trial tests a new therapy called Emotional Awareness and Expression Therapy (EAET) for people with migraines. EAET helps individuals recognize and express difficult emotions to reduce stress and emotional pain. The goal is to see if this therapy can lower the frequency and severity of migraine attacks.
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
Recruiting1 awardPhase 3
Toronto, Ontario
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
Recruiting1 award5 criteria
Aurora, Colorado
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Trials for Headache Patients
Behavioral Intervention
CBT + Amitriptyline for Childhood Migraine
Recruiting1 award4 criteria
Birmingham, Alabama
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
Recruiting1 award5 criteria
Aurora, Colorado
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Behavioral Intervention
Behavioral Treatment for Migraines
Recruiting1 award2 criteria
Stanford, California
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Local Anesthetic
Exparel for Craniofacial Pain
Recruiting0 awardsPhase 2
Stanford, California
This trial tests if injecting Exparel into the nasal area can help people with craniofacial pain. Exparel is a long-lasting pain reliever, and the study focuses on those who usually get pain relief from Lidocaine during ENT procedures.
Phase 3 Trials
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
Recruiting1 awardPhase 3
Toronto, Ontario
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Monoclonal Antibodies
Erenumab for Migraine
Recruiting1 awardPhase 3
Colorado Springs, Colorado
This trial tests if erenumab, an injection given regularly, can reduce migraine days in children and adolescents with chronic migraines by blocking a protein that triggers these headaches. Erenumab has been shown to reduce migraine days and improve quality of life in adults with chronic and episodic migraines.
Eptinezumab for Chronic Migraine in Adolescents
Recruiting1 awardPhase 3
Norfolk, Virginia
This trial is testing if eptinezumab, given through an IV, can reduce migraine days in young people aged 12 to 17 who have chronic migraines. Eptinezumab works by blocking a protein that causes migraines. Participants will receive different amounts of the treatment to compare the effects. Eptinezumab has been shown to be effective and safe for preventing migraines in adults.
Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
Rimegepant for Pediatric Migraine
Recruiting2 awardsPhase 3
Anaheim, California
This trial aims to test the safety of rimegepant, a medication for treating migraines. The study focuses on children and adolescents aged 6 to 17 years who experience moderate to severe migraines. Rimegepant works by blocking a protein that triggers migraine pain, helping to alleviate symptoms.
Trials With No Placebo
Behavioral Intervention
CBT + Amitriptyline for Childhood Migraine
Recruiting1 award4 criteria
Birmingham, Alabama
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Emotional Awareness and Expression Therapy for Migraine
Recruiting1 award
Salt Lake City, Utah
This trial tests a new therapy called Emotional Awareness and Expression Therapy (EAET) for people with migraines. EAET helps individuals recognize and express difficult emotions to reduce stress and emotional pain. The goal is to see if this therapy can lower the frequency and severity of migraine attacks.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
Recruiting1 award5 criteria
Aurora, Colorado
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Behavioral Intervention
Online Intervention for Migraines
Recruiting1 awardPhase 2
Cincinnati, Ohio
This trial is testing whether an online intervention can help improve headache outcomes for adolescents with migraines, compared to an attention control intervention. The primary outcome will be the number of headache days, assessed via online daily diary pre- and post-intervention.
View More Related Trials
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.