Monoclonal Antibodies
Ocrelizumab for Psychosis
Recruiting1 awardPhase 1 & 2
Houston, Texas
This trial is investigating whether some people diagnosed with schizophrenia or bipolar disorder may actually have a brain disease caused by auto-antibodies. These auto-antibodies attack brain receptors, leading to symptoms
Stem Cell Therapy
SSC Transplant + Testicular Tissue Grafting for Male Infertility
Recruiting1 award4 criteria
Pittsburgh, Pennsylvania
This trial tests two methods to help men who stored testicular tissue before harmful treatments. It aims to restore their ability to produce sperm by reintroducing essential cells into their testes.
CAR T-cell Therapy
Cell Depletion using CliniMACS for Primary Immunodeficiencies
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial is testing a new way to do a stem cell transplant using cells from either an unrelated or partially matched related donor. There are two different ways to do the transplant depending on the patient's diagnosis and age.
Popular Filters
Trials for Multiple Sclerosis Patients
Anti-bacterial
Oral Antibiotics for Prosthetic Joint Infections
Recruiting3 awardsPhase 4
Little Rock, Arkansas
This trial is testing whether a 7-day course of an oral, prophylactic antibiotic can reduce the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.
Thromboxane A2 Receptor Antagonist
Oral Ifetroban for Scleroderma
Recruiting0 awardsPhase 2
Tucson, Arizona
This trial is testing ifetroban, an oral medication, in patients with severe forms of systemic sclerosis. The goal is to see if it can reduce inflammation and improve blood flow, potentially helping to manage their condition better.
Monoclonal Antibodies
Rituximab + Cyclosporine for Glomerulonephritis
Recruiting1 awardPhase 2
Bethesda, Maryland
This trial is testing the safety and effectiveness of combining two drugs to treat membranous nephropathy, a kidney disease associated with damage to the walls of the glomeruli. The first drug, rituximab, is an immunosuppressant that attempts to reduce the activity of the immune system. The second drug, cyclosporine, is a blood pressure lowering medication. The trial will last up to 2 years, and participants will have frequent blood and urine tests.
Neurostimulation Device
VNS for Epilepsy
Recruiting1 award2 criteria
Louisville, Kentucky
This trial is studying whether vagal nerve stimulation (VNS) for epilepsy affects bowel habits and the gut microbiome. VNS is a neurosurgical procedure where an impulse generator is placed near the vagus nerve in the neck.
Trials for Myasthenia Gravis Patients
Anti-bacterial
Oral Antibiotics for Prosthetic Joint Infections
Recruiting3 awardsPhase 4
Little Rock, Arkansas
This trial is testing whether a 7-day course of an oral, prophylactic antibiotic can reduce the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.
Thromboxane A2 Receptor Antagonist
Oral Ifetroban for Scleroderma
Recruiting0 awardsPhase 2
Tucson, Arizona
This trial is testing ifetroban, an oral medication, in patients with severe forms of systemic sclerosis. The goal is to see if it can reduce inflammation and improve blood flow, potentially helping to manage their condition better.
Monoclonal Antibodies
Rituximab + Cyclosporine for Glomerulonephritis
Recruiting1 awardPhase 2
Bethesda, Maryland
This trial is testing the safety and effectiveness of combining two drugs to treat membranous nephropathy, a kidney disease associated with damage to the walls of the glomeruli. The first drug, rituximab, is an immunosuppressant that attempts to reduce the activity of the immune system. The second drug, cyclosporine, is a blood pressure lowering medication. The trial will last up to 2 years, and participants will have frequent blood and urine tests.
Topoisomerase II inhibitors
Stem Cell Transplant for Autoimmune Neurological Diseases
Recruiting1 awardPhase 2
Denver, Colorado
This trial tests a combination of strong chemotherapy and an immune-suppressing medicine followed by a stem cell transplant. It targets patients with autoimmune neurological diseases that haven't improved with other treatments. The treatment aims to weaken the immune system to stop it from attacking the nervous system and then helps the body recover by making new blood cells. High-dose chemotherapy followed by a stem cell transplant has been shown to improve various autoimmune diseases.
Neurostimulation Device
VNS for Epilepsy
Recruiting1 award2 criteria
Louisville, Kentucky
This trial is studying whether vagal nerve stimulation (VNS) for epilepsy affects bowel habits and the gut microbiome. VNS is a neurosurgical procedure where an impulse generator is placed near the vagus nerve in the neck.
Stem Cell Transplant
Bone Marrow/Kidney Transplant for Blood Disorders & Chronic Kidney Disease
Recruiting1 award11 criteria
Boston, Massachusetts
This trial is for a combined bone marrow and kidney transplant from a partially matched related donor to treat a blood disorder and kidney disease. The expectation is to have 10 people participate.
Trials With No Placebo
Anti-metabolites
CC-97540 for Severe Refractory Lupus
Recruiting1 awardPhase 1
Denver, Colorado
This trial is testing a new drug called CC-97540. It aims to help people with severe autoimmune diseases that don't get better with regular treatments. Researchers want to see if the drug is safe, how it moves through the body, and if it can improve patients' health.
Procedure
Stem Cell Transplant for Autoimmune Diseases
Recruiting1 awardPhase 2
Philadelphia, Pennsylvania
This trial is testing a new treatment strategy for children and young adults with autoimmune diseases that are unresponsive to conventional treatments. The new treatment involves delivering high doses of immunosuppressive therapy followed by an autologous stem cell transplant (ASCT). The goal is to purge the pathogenic, autoreactive immune system and reset the immune system.
Anti-bacterial
Oral Antibiotics for Prosthetic Joint Infections
Recruiting3 awardsPhase 4
Little Rock, Arkansas
This trial is testing whether a 7-day course of an oral, prophylactic antibiotic can reduce the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.
Monoclonal Antibodies
Rituximab + Cyclosporine for Glomerulonephritis
Recruiting1 awardPhase 2
Bethesda, Maryland
This trial is testing the safety and effectiveness of combining two drugs to treat membranous nephropathy, a kidney disease associated with damage to the walls of the glomeruli. The first drug, rituximab, is an immunosuppressant that attempts to reduce the activity of the immune system. The second drug, cyclosporine, is a blood pressure lowering medication. The trial will last up to 2 years, and participants will have frequent blood and urine tests.
Topoisomerase II inhibitors
Stem Cell Transplant for Autoimmune Neurological Diseases
Recruiting1 awardPhase 2
Denver, Colorado
This trial tests a combination of strong chemotherapy and an immune-suppressing medicine followed by a stem cell transplant. It targets patients with autoimmune neurological diseases that haven't improved with other treatments. The treatment aims to weaken the immune system to stop it from attacking the nervous system and then helps the body recover by making new blood cells. High-dose chemotherapy followed by a stem cell transplant has been shown to improve various autoimmune diseases.
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.