Popular Trials
Kinase Inhibitor
Turalio for Leukemia
Recruiting1 awardPhase 1
Bethesda, Maryland
This trial is testing a drug called PLX3397 to see if it can help treat certain types of cancer. Eligible participants will take the drug once daily for a 28-day cycle, and will have various tests and procedures throughout the study.
Popular Filters
Trials for Neurofibromatosis Patients
Kinase Inhibitor
Selumetinib for Plexiform Neurofibroma
Recruiting1 awardPhase 1
Rochester, Minnesota
This trial is testing how well selumetinib works when taken with a low-fat meal in adolescents with NF1 who have tumors that can't be removed by surgery. The goal is to see if eating a low-fat meal affects how the body absorbs the medication and if it helps reduce stomach-related side effects. Selumetinib is being investigated for its effectiveness in treating NF1-associated tumors, with previous studies showing promising positive results in patients.
MEK1/2 inhibitor
FCN-159 for Neurofibromatosis
Recruiting1 awardPhase 1 & 2
Detroit, Michigan
This trial is testing FCN-159, a new drug taken by mouth, for patients with advanced solid tumors and neurofibromatosis type 1. The drug works by blocking specific proteins that help cancer cells grow. This targeted approach aims to slow down or stop the progression of these diseases.
Kinase Inhibitor
Selumetinib for Plexiform Neurofibromas
Recruiting1 awardPhase 3
Gainesville, Florida
This trial is testing a medication called selumetinib to see if it can help adults with a condition called NF1 who have tumors that cause symptoms and cannot be removed by surgery. The medication works by blocking signals that make the tumors grow.
MEK Inhibitor
MEK Inhibitor for Neurofibromatosis
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial tests mirdametinib, a medication taken by mouth, for patients with NF1-related tumors that can't be surgically removed. The drug works by blocking specific proteins to stop or shrink the tumors. Mirdametinib has shown significant and lasting decreases in pain and partial responses in NF1-related plexiform neurofibromas.
Trials for PNs Patients
MEK1/2 inhibitor
FCN-159 for Neurofibromatosis
Recruiting1 awardPhase 1 & 2
Detroit, Michigan
This trial is testing FCN-159, a new drug taken by mouth, for patients with advanced solid tumors and neurofibromatosis type 1. The drug works by blocking specific proteins that help cancer cells grow. This targeted approach aims to slow down or stop the progression of these diseases.
Kinase Inhibitor
Selumetinib for Plexiform Neurofibromas
Recruiting1 awardPhase 3
Gainesville, Florida
This trial is testing a medication called selumetinib to see if it can help adults with a condition called NF1 who have tumors that cause symptoms and cannot be removed by surgery. The medication works by blocking signals that make the tumors grow.
MEK Inhibitor
MEK Inhibitor for Neurofibromatosis
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial tests mirdametinib, a medication taken by mouth, for patients with NF1-related tumors that can't be surgically removed. The drug works by blocking specific proteins to stop or shrink the tumors. Mirdametinib has shown significant and lasting decreases in pain and partial responses in NF1-related plexiform neurofibromas.
Mitogen-activated Protein Kinase (MAPK) Inhibitor
Trametinib for Pediatric Brain Tumor
Recruiting1 awardPhase 2
Calgary, Alberta
This trial will study the response rate of pediatric brain tumors to oral administration of the drug trametinib. A total of 150 patients will be recruited, and the study will also explore the molecular mechanisms behind tumor development, progression and resistance to treatment.
Trials for NF1 Positive Patients
Kinase Inhibitor
Selumetinib for Plexiform Neurofibroma
Recruiting1 awardPhase 1
Rochester, Minnesota
This trial is testing how well selumetinib works when taken with a low-fat meal in adolescents with NF1 who have tumors that can't be removed by surgery. The goal is to see if eating a low-fat meal affects how the body absorbs the medication and if it helps reduce stomach-related side effects. Selumetinib is being investigated for its effectiveness in treating NF1-associated tumors, with previous studies showing promising positive results in patients.
MEK1/2 inhibitor
FCN-159 for Neurofibromatosis
Recruiting1 awardPhase 1 & 2
Detroit, Michigan
This trial is testing FCN-159, a new drug taken by mouth, for patients with advanced solid tumors and neurofibromatosis type 1. The drug works by blocking specific proteins that help cancer cells grow. This targeted approach aims to slow down or stop the progression of these diseases.
Kinase Inhibitor
Selumetinib for Plexiform Neurofibromas
Recruiting1 awardPhase 3
Gainesville, Florida
This trial is testing a medication called selumetinib to see if it can help adults with a condition called NF1 who have tumors that cause symptoms and cannot be removed by surgery. The medication works by blocking signals that make the tumors grow.
MEK Inhibitor
MEK Inhibitor for Neurofibromatosis
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial tests mirdametinib, a medication taken by mouth, for patients with NF1-related tumors that can't be surgically removed. The drug works by blocking specific proteins to stop or shrink the tumors. Mirdametinib has shown significant and lasting decreases in pain and partial responses in NF1-related plexiform neurofibromas.
Trials With No Placebo
Kinase Inhibitor
Selumetinib for Plexiform Neurofibroma
Recruiting1 awardPhase 1
Rochester, Minnesota
This trial is testing how well selumetinib works when taken with a low-fat meal in adolescents with NF1 who have tumors that can't be removed by surgery. The goal is to see if eating a low-fat meal affects how the body absorbs the medication and if it helps reduce stomach-related side effects. Selumetinib is being investigated for its effectiveness in treating NF1-associated tumors, with previous studies showing promising positive results in patients.
MEK1/2 inhibitor
FCN-159 for Neurofibromatosis
Recruiting1 awardPhase 1 & 2
Detroit, Michigan
This trial is testing FCN-159, a new drug taken by mouth, for patients with advanced solid tumors and neurofibromatosis type 1. The drug works by blocking specific proteins that help cancer cells grow. This targeted approach aims to slow down or stop the progression of these diseases.
MEK Inhibitor
MEK Inhibitor for Neurofibromatosis
Recruiting1 awardPhase 2
Birmingham, Alabama
This trial tests mirdametinib, a medication taken by mouth, for patients with NF1-related tumors that can't be surgically removed. The drug works by blocking specific proteins to stop or shrink the tumors. Mirdametinib has shown significant and lasting decreases in pain and partial responses in NF1-related plexiform neurofibromas.
Mitogen-activated Protein Kinase (MAPK) Inhibitor
Trametinib for Pediatric Brain Tumor
Recruiting1 awardPhase 2
Calgary, Alberta
This trial will study the response rate of pediatric brain tumors to oral administration of the drug trametinib. A total of 150 patients will be recruited, and the study will also explore the molecular mechanisms behind tumor development, progression and resistance to treatment.
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.