Popular Trials
Anticoagulant
Defibrotide Prophylaxis + Stem Cell Transplant for Sickle Cell Disease
Recruiting1 awardPhase 2
Los Angeles, California
This trial tests if Defibrotide can safely and effectively prevent liver damage in high-risk sickle cell or beta thalassemia patients undergoing a special stem cell transplant. The medication works by improving blood flow in the liver to prevent blockages.
Amino Acid Supplement
L-Citrulline for Sickle Cell Disease
Recruiting0 awardsPhase 2
Washington, District of Columbia
This trial aims to investigate if intravenous citrulline can help reduce acute pain in hospitalized patients with sickle cell disease. Researchers will compare the effects of intravenous citrulline to a
Procedure
Motixafortide + Natalizumab for Sickle Cell Disease
Recruiting1 awardPhase 1
Saint Louis, Missouri
This trial is testing two drugs, motixafortide and natalizumab, to help patients with sickle cell disease. These drugs aim to move more stem cells from the bone marrow into the blood, making it easier to collect them for gene therapy. Natalizumab is also used to treat multiple sclerosis.
Tetracycline Antibiotic
Minocycline for Cognitive Decline in Sickle Cell Disease
Recruiting0 awardsPhase 1
Cincinnati, Ohio
This trial will investigate if the antibiotic minocycline can stop/reverse cognitive decline in people with Sickle Cell Disease, a disorder which affects people of African ancestry and can lead to learning, memory, and attention problems due to brain inflammation.
Popular Filters
Trials for SCD Patients
Behavioural Intervention
SCThrive for Sickle Cell Anemia
Recruiting0 awardsPhase 2
Wilmington, Delaware
This trial aims to see if a self-management intervention called SCThrive can improve the health and well-being of 260 adolescents and young adults with sickle cell disease. The trial will assess if SC
Carbon Dioxide for Sickle Cell Anemia
Recruiting1 award10 criteria
Saint Louis, Missouri
This trial is looking at how blood flow and metabolism affects brain development in early life. SCA participants and healthy controls will have their blood flow and metabolism examined using MRI, and will also undergo cognitive assessments and brief questionnaires.
Trials for Sickle Cell Anemia Patients
Behavioural Intervention
SCThrive for Sickle Cell Anemia
Recruiting0 awardsPhase 2
Wilmington, Delaware
This trial aims to see if a self-management intervention called SCThrive can improve the health and well-being of 260 adolescents and young adults with sickle cell disease. The trial will assess if SC
Carbon Dioxide for Sickle Cell Anemia
Recruiting1 award10 criteria
Saint Louis, Missouri
This trial is looking at how blood flow and metabolism affects brain development in early life. SCA participants and healthy controls will have their blood flow and metabolism examined using MRI, and will also undergo cognitive assessments and brief questionnaires.
Trials for HbSS Positive Patients
Hematopoietic Stem Cell Transplantation
Stem Cell Transplant for Sickle Cell Disease
Recruiting1 awardPhase 1 & 2
Oakland, California
This trial is testing a new treatment for sickle cell disease which involves transplanting stem cells. The goal is to evaluate the safety and effectiveness of the treatment.
Phase 3 Trials
Gene Therapy
CTX001 for Sickle Cell Disease
Recruiting1 awardPhase 2 & 3
Palo Alto, California
This trial is testing a possible new treatment for sickle cell disease using CRISPR-Cas9 technology to modify patients' own stem cells. The goal is to improve safety and efficacy compared to current treatments.
Small Molecule
Etavopivat for Sickle Cell Disease
Recruiting1 awardPhase 3
Little Rock, Arkansas
This trial is testing a drug called etavopivat to see if it can help people with sickle cell disease. The drug aims to improve blood health and reduce pain by making red blood cells work better. The study includes patients aged 12 to 65.
Gene Therapy
Gene Therapy for Sickle Cell Disease
Recruiting2 awardsPhase 3
Birmingham, Alabama
This trial is studying a gene therapy for sickle cell disease. The FDA has put a partial clinical hold on the trial for patients less than 18 years of age, which means that no new enrollment, cell collection, conditioning, or drug product infusion can be initiated in pediatric patients. The study is still open to patients 18 years of age and older.
Trials With No Placebo
Carbon Dioxide for Sickle Cell Anemia
Recruiting1 award10 criteria
Saint Louis, Missouri
This trial is looking at how blood flow and metabolism affects brain development in early life. SCA participants and healthy controls will have their blood flow and metabolism examined using MRI, and will also undergo cognitive assessments and brief questionnaires.
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.