MEK Inhibitor
AZD6244 + Chemotherapy for Advanced Cancer
This study is evaluating whether a combination of AZD6244 given orally twice a day with standard doses of selected chemotherapies will be safe and tolerable for cancer patients with advanced solid tumors. The highest tolerated dose of AZD6244 in combination with selected chemotherapies will be evaluated
Cancer Vaccine
Autogene Cevumeran + Atezolizumab for Cancer
This trial tests a personalized cancer vaccine and an immune-boosting drug in cancer patients. The vaccine teaches the body to attack cancer, while the drug helps immune cells find and kill hidden cancer cells. This approach aims to induce strong anti-tumor responses by selecting suitable vaccines based on the patient's existing immune system.
Cancer Vaccine
NeoVax + Ipilimumab for Kidney Cancer
This trial is testing a new cancer vaccine for kidney cancer. The vaccine is personalized, meaning it is made from each patient's own tumor. The study will also test two other drugs, Poly-ICLC and Ipilimumab, in combination with the vaccine.
Popular Filters
Trials for Kidney Cell Carcinoma Patients
Cyclin-Dependent Kinase Inhibitor
NKT2152 + Palbociclib + Sasanlimab for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer who have already tried other treatments. The goal is to see if these drugs can work better together to stop cancer growth and help the immune system fight the disease.
Cryoablation
Cryoablation-Assisted Surgery for Kidney Cancer
This trial will compare two methods of controlling blood loss during surgery for kidney cancer: renal cryoablation (freezing the tumor) and selective arterial renal ischemia (restricting blood flow to the kidney).
HIF2α Inhibitor
Oral NKT2152 for Kidney Cancer
This trial is testing NKT2152, a new oral drug, in adults with a specific type of kidney cancer who have no other treatment options. It aims to find the safest dose and see if the drug can effectively fight the cancer.
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
Trials for Renal Cell Cancer Patients
Cyclin-Dependent Kinase Inhibitor
NKT2152 + Palbociclib + Sasanlimab for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer who have already tried other treatments. The goal is to see if these drugs can work better together to stop cancer growth and help the immune system fight the disease.
Cryoablation
Cryoablation-Assisted Surgery for Kidney Cancer
This trial will compare two methods of controlling blood loss during surgery for kidney cancer: renal cryoablation (freezing the tumor) and selective arterial renal ischemia (restricting blood flow to the kidney).
HIF2α Inhibitor
Oral NKT2152 for Kidney Cancer
This trial is testing NKT2152, a new oral drug, in adults with a specific type of kidney cancer who have no other treatment options. It aims to find the safest dose and see if the drug can effectively fight the cancer.
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
Trials for Metastatic Patients
Cyclin-Dependent Kinase Inhibitor
NKT2152 + Palbociclib + Sasanlimab for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer who have already tried other treatments. The goal is to see if these drugs can work better together to stop cancer growth and help the immune system fight the disease.
HIF2α Inhibitor
Oral NKT2152 for Kidney Cancer
This trial is testing NKT2152, a new oral drug, in adults with a specific type of kidney cancer who have no other treatment options. It aims to find the safest dose and see if the drug can effectively fight the cancer.
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
Histone Deacetylase Inhibitor
Entinostat + Aldesleukin for Kidney Cancer
This trial is testing a combination of drugs to treat metastatic kidney cancer. Entinostat may stop tumor cell growth, and aldesleukin may stimulate white blood cells to kill cancer cells. The goal is to see if this combination is more effective than current treatments.
Phase 3 Trials
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
Pembrolizumab for Bladder Cancer
This trial looks at how well pembrolizumab works in treating patients with muscle-invasive bladder cancer or locally advanced urothelial cancer. Monoclonal antibodies that block the PD-1 axis can interfere with the ability of tumor cells to grow.
Tyrosine Kinase Inhibitor
Pazopanib for Renal Cell Carcinoma
This trial is testing whether pazopanib hydrochloride can help prevent the return of kidney cancer in patients who have had surgery to remove it. The medication aims to stop cancer cell growth and block blood flow to tumors. Patients will take the drug for several months and be monitored frequently. Pazopanib has been approved for treating kidney cancer since 2009.
Trials With No Placebo
Cyclin-Dependent Kinase Inhibitor
NKT2152 + Palbociclib + Sasanlimab for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer who have already tried other treatments. The goal is to see if these drugs can work better together to stop cancer growth and help the immune system fight the disease.
Cryoablation
Cryoablation-Assisted Surgery for Kidney Cancer
This trial will compare two methods of controlling blood loss during surgery for kidney cancer: renal cryoablation (freezing the tumor) and selective arterial renal ischemia (restricting blood flow to the kidney).
HIF2α Inhibitor
Oral NKT2152 for Kidney Cancer
This trial is testing NKT2152, a new oral drug, in adults with a specific type of kidney cancer who have no other treatment options. It aims to find the safest dose and see if the drug can effectively fight the cancer.
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
View More Related Trials
Frequently Asked Questions
Introduction to kidney cancer
What are the top hospitals conducting kidney cancer research?
When it comes to advancing the treatment options for kidney cancer, several top hospitals across the United States are leading the charge. In Sacramento, California, the University of California Davis Comprehensive Cancer Center is currently conducting 11 active clinical trials focused on kidney cancer. Although they have a relatively lower number of all-time trials at just 10, their dedication to this field began in 2006 when they recorded their first-ever kidney cancer trial.
Moving down south to Los Angeles, USC / Norris Comprehensive Cancer Center is making significant contributions as well. With 10 ongoing kidney cancer trials and eight completed trials thus far, this institution has been actively exploring innovative solutions since their initial involvement in renal cancer research back in 2009.
On the opposite coast, Boston's prestigious Dana Farber Cancer Institute showcases its commitment to combating kidney cancer with eight active clinical trials and an impressive history of 11 previous studies conducted since initiating their inaugural trial in 2014. Meanwhile, another renowned facility located within Boston—the Dana-Farber Cancer Institute—has also made substantial strides in understanding and treating this condition. They have achieved a remarkable track record of eight ongoing clinical trials and a substantial contribution of twenty-two completed studies since embarking on their first-ever kidney cancer trial way back in1995.
Rounding out our list is New york City's Memorial Sloan Kettering Cancer Center which shares similar accomplishments with eight active kidney cancer trials underway and an extensive portfolio that includes twenty-three previously conducted studies dating back to their inaugural trial recorded in2000.
These leading hospitals collectively demonstrate unwavering determination to combat one of the most common types of cancers worldwide – Kidney Cancer. By continuously pushing boundaries through groundbreaking research initiatives and cutting-edge clinical trials these institutions bring hope not only for current patients but also for those yet to face such challenging situations; ultimately paving a path towards better treatments, improved outcomes,and brighter futures for individuals affected by this disease globally.
Which are the best cities for kidney cancer clinical trials?
When it comes to kidney cancer clinical trials, several cities excel in research and development. Los Angeles, California leads the pack with 58 active trials focusing on treatments like everolimus, Avelumab (MSB0010718C), and Nephrectomy. Boston, Massachusetts closely follows with 42 ongoing studies investigating Ipilimumab, Nivolumab, Avelumab (MSB0010718C), and more. Denver, Colorado also makes a mark with 30 active trials exploring Pharmacological Study, everolimus, Cabozantinib among others. These cities offer individuals battling kidney cancer access to cutting-edge clinical trials that pave the way for advancements in care and hope for better outcomes.
Which are the top treatments for kidney cancer being explored in clinical trials?
Exciting advancements in kidney cancer research have led to the exploration of several promising treatments in clinical trials. Nivolumab, a groundbreaking drug first listed in 2014, is currently being tested in five active trials and has been involved in a total of 20 kidney cancer trials so far. Another contender making waves is ipilimumab with four ongoing trials and ten all-time kidney cancer studies since its introduction in 2014. In addition, cabozantinib shows promise with four active and six all-time kidney cancer trials since its listing in 2012. Last but not least, pembrolizumab joins the ranks with three active and nine all-time kidney cancer studies since it was introduced to the scene in 2015. These innovative treatments offer hope for improved outcomes for patients fighting this formidable disease.
What are the most recent clinical trials for kidney cancer?
Exciting developments have emerged in recent clinical trials for kidney cancer, offering new possibilities for treatment. One noteworthy trial involves the evaluation of a triplet combination therapy in phase 2, showing potential efficacy against kidney cancer. Another promising study focuses on cabozantinib, also in phase 2, as a potential therapeutic option for patients with this type of cancer. Additionally, interventions aimed at improving outcomes and patient care continue to be explored through a phase 4 trial. These advancements highlight the ongoing commitment to finding effective treatments for kidney cancer and bring hope to those affected by this challenging disease.
What kidney cancer clinical trials were recently completed?
Several recent clinical trials have provided valuable insights into the treatment of kidney cancer. Notably, in October 2020, UNC Lineberger Comprehensive Cancer Center concluded a trial investigating Perflutren lipid microsphere's potential benefits. Preceding this, in September 2019, another trial sponsored by the same institution explored Perflutren lipid microsphere for kidney cancer. Earlier studies include M.D. Anderson Cancer Center's examination of Sitravatinib in April 2017 and Ludwig Institute for Cancer Research's investigation of Tremelimumab in December 2016. Further research includes Novartis Pharmaceuticals' study on PDR001 (completed October 2016), National Cancer Institute's exploration of INC280 (completed January 2014), NCI's evaluation of Cabozantinib (completed September 2012), and M.D. Anderson Cancer Center's analysis of Axitinib (completed February 2011). These comprehensive investigations contribute to expanding our understanding and advancing treatment options for patients with kidney cancer.