PEMF Therapy for Postoperative Pain After Orthopedic Surgery
This trial is testing whether PEMF therapy can help reduce pain in patients who have had shoulder or knee surgery. PEMF therapy uses electromagnetic waves to interact with the body's cells, which may reduce pain and speed up healing. The study will measure pain levels, medication use, and physical function after surgery. PEMF therapy has been evaluated as a therapeutic strategy for pain management in several clinical scenarios, showing positive efficacy and safety profiles.
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Trials for TKR Patients
Corticosteroid
Medrol Dosepak for Total Knee Replacement
This trial will test whether an oral methylprednisolone taper can help improve pain and function following outpatient total knee arthroplasty, as well as decrease opioid use, nausea, and complications.
Duloxetine for Postoperative Pain After Knee Surgery
This trial is testing if duloxetine can help reduce pain and opioid use in patients after knee replacement surgery. It focuses on patients who often have severe pain or heightened pain sensitivity. Duloxetine may work by altering brain chemicals to lessen pain signals. Duloxetine has been shown to have significant pain-relieving effects for managing chronic pain associated with conditions like fibromyalgia and diabetic peripheral neuropathic pain.
Trials for Osteoarthritis Patients
Dronabinol for Knee Surgery Pain
This trial will test whether dronabinol, a medication derived from marijuana, is effective in relieving pain after arthroscopic knee surgery, with the hope of expanding the trial to other types of orthopedic surgery if results are promising.
Procedure
Chondro-Gide® for Knee Cartilage Injury
This trial uses a special surgery combined with a protective membrane to treat large knee cartilage damage. It aims to help patients who might not benefit as much from the surgery alone. The treatment encourages new cartilage growth and protects it with the membrane.
Behavioural Intervention
SOAR Program for Preventing Osteoarthritis After ACL Tear
This trial aims to help young people who have torn their knee ligament and undergone surgery. Participants will either receive a 6-month virtual education and exercise program or a minimal intervention. The study will assess
Trials With No Placebo
Behavioural Intervention
Weightbearing Strategies After Knee Ligament Surgery for Knee Injuries
This trial is testing whether it is safe for patients who have had surgery on their posterior cruciate ligament, medial collateral ligament, or a combination of multiple ligaments, to start partial weightbearing six weeks after surgery.
Behavioural Intervention
Blood Flow Restriction Training for Knee Instability
This trial is testing whether using an air cuff to limit blood flow during physical therapy helps people with unstable kneecaps recover faster. Patients will receive either regular physical therapy or regular therapy plus this new method. The goal is to see if this approach helps muscles get stronger more quickly.
Procedure
Chondro-Gide® for Knee Cartilage Injury
This trial uses a special surgery combined with a protective membrane to treat large knee cartilage damage. It aims to help patients who might not benefit as much from the surgery alone. The treatment encourages new cartilage growth and protects it with the membrane.
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Frequently Asked Questions
Introduction to knee replacement
What are the top hospitals conducting knee replacement research?
When it comes to advancing the field of knee replacement surgeries, several top hospitals around the world are making significant contributions. In Edina, Minnesota, Twin Cities Orthopedics is at the forefront with three active knee replacement trials and a total of three completed trials thus far. This hospital made its first recorded foray into knee replacement research in 2020. Similarly dedicated to improving outcomes for patients with knee issues, the Hospital for Special Surgery in New york has three ongoing clinical trials with one previously conducted trial dating back to 2004.
Moving across state lines to Lebanon, New hampshire, Dartmouth Hitchcock Medical Center is actively involved in two current knee replacement trials while having accomplished two previous studies as well since initiating their first recorded trial just recently in 2022.
Meanwhile, located in Hamilton, Ontario's St. Joseph's Healthcare Hamilton also plays a crucial role by conducting two active knee replacement trials and recording their initial investigation on this matter alongside Twin Cities Orthopedics during 2020 itself; they've made further progress than Hospital #2 as only have managed one all-time study yet.The London Health Sciences Centre from Canada may not boast any completed studies specifically focused on knee replacements but remains an important institution contributing towards advancements through their involvement in two ongoing clinical trials.
These hospitals serve as beacons of innovation and collaboration within orthopedic medicine and symbolize hope for individuals suffering from debilitating conditions that require knee replacements. By pushing boundaries and exploring new techniques or technologies through these remarkable clinical trials worldwide organizations endeavor towards providing better quality lives whilst continuing efforts shaping future standards healthcare treatment
Which are the best cities for knee replacement clinical trials?
When it comes to knee replacement clinical trials, several cities lead the way in research and innovation. New york City stands out with 5 active trials exploring treatments like Microfracture plus placement of Chondro-Gide® ACC and Navio™ Robotics-assisted Surgical System. London, Ontario follows closely behind with 4 ongoing studies focused on techniques such as Measured resection technique and POROUS TIBIA BASEPLATE W/ JRNY LOCK. Edina, Minnesota also contributes to the field with 3 active trials examining interventions like Physical Therapy and MRI. These cities hold great promise for individuals seeking advancements in knee replacement procedures through cutting-edge clinical trials that aim to improve outcomes and quality of life.
Which are the top treatments for knee replacement being explored in clinical trials?
In the realm of knee replacement research, clinical trials are exploring various treatments to improve outcomes. Physical therapy is taking center stage with two active trials and a total of two all-time knee replacement trials since its listing in 2020. MRI, on the other hand, shows promise as a diagnostic tool with one ongoing trial and one historical study focused on knee replacements since its introduction also in 2020. Another intriguing treatment gaining attention is falling training, currently being investigated in one active trial alongside an all-time record of one knee replacement trial since its recent debut in 2022. These innovative approaches hold potential for enhancing the success rates and overall quality of life for those undergoing knee replacement surgery.
What are the most recent clinical trials for knee replacement?
Exciting advancements in knee replacement research offer new possibilities for improved outcomes and patient comfort. Clinical trials have explored various approaches to enhance post-operative pain management and recovery. The efficacy of F14 combined with multimodal analgesia has been investigated in a phase 3 trial, demonstrating potential benefits for patients undergoing knee replacement surgery. Another phase 3 trial evaluated the use of Dronabinol, a drug derived from cannabis, as an adjunctive therapy for post-operative pain relief. Additionally, studies have delved into the effectiveness of Venlafaxine at a dosage of 37.5 MG and non-stiff intravenous hydrocortisone in improving patient outcomes after knee replacement surgery. These recent clinical trials provide hope for optimizing care and enhancing the overall experience of individuals undergoing knee replacement procedures.
What knee replacement clinical trials were recently completed?
Recently, several clinical trials focused on knee replacement have concluded, presenting promising advancements in the field.