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Trials for Hepatocellular Carcinoma Patients
Chemotherapy
Contrast-Enhanced Ultrasound for Liver Cancer
This trial assesses the use of a specific type of ultrasound, called contrast-enhanced ultrasound (CEUS), to see how well it can determine if the treatment is working for liver tumors in patients undergoing
Anti-adhesive Film
Anti-Adhesive Film for Tissue Adhesions
This trial will evaluate the effectiveness of using a hyaluronan and cellulose based antiadhesive film at the time of index hepatectomy in reducing perihepatic adhesions at the time of repeat hepatic surgery.
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
Local Anesthetic
Spinal Anesthesia for Liver Surgery
This trial will compare epidural and spinal anesthetics for liver resection surgery to see if spinal anesthesia can help reduce blood pressure & IV fluid use, while providing the same pain control & faster recovery.
Trials for HCC Patients
Monoclonal Antibodies
Anti-TIM-3 + Anti-PD-1 Antibodies for Liver Cancer
This trial is testing two drugs, cobolimab and dostarlimab, to help the immune system fight advanced or spreading liver cancer. The drugs work by blocking proteins that allow cancer cells to hide from the immune system, making it easier for the body to attack them.
Trials for Metastatic Patients
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
Hypoxia-activating Agent
Tirapazamine + Embolization for Liver Cancer
This trial is testing a new cancer treatment involving two drugs. The first drug is given before the second drug, which is used to block blood flow to the tumor. The treatment will be given to people with liver cancer who are eligible based on their health. The effects of the treatment will be monitored with MRIs.
Anti-metabolites
Floxuridine for Pancreatic Cancer
This trial is testing a new way to treat pancreatic cancer that has spread to the liver. Patients will receive a special chemotherapy drug directly into their liver through a pump, along with their usual chemotherapy. The goal is to see if this method helps them live longer.
Trials With No Placebo
Chemotherapy
Contrast-Enhanced Ultrasound for Liver Cancer
This trial assesses the use of a specific type of ultrasound, called contrast-enhanced ultrasound (CEUS), to see how well it can determine if the treatment is working for liver tumors in patients undergoing
Anti-adhesive Film
Anti-Adhesive Film for Tissue Adhesions
This trial will evaluate the effectiveness of using a hyaluronan and cellulose based antiadhesive film at the time of index hepatectomy in reducing perihepatic adhesions at the time of repeat hepatic surgery.
Procedure
Histotripsy with HistoSonics System for Liver Cancer
This trial tests a device that uses sound waves to break down liver tumors. It targets patients with liver tumors that may not respond to other treatments. The device works by creating bubbles in the tumor, which then burst and destroy the tumor cells.
Local Anesthetic
Spinal Anesthesia for Liver Surgery
This trial will compare epidural and spinal anesthetics for liver resection surgery to see if spinal anesthesia can help reduce blood pressure & IV fluid use, while providing the same pain control & faster recovery.
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Frequently Asked Questions
Introduction to liver cancer
What are the top hospitals conducting liver cancer research?
When it comes to the battle against liver cancer, several top hospitals are leading the way in groundbreaking clinical trials. One of these institutions is the renowned Mayo Clinic located in Rochester. With 10 active liver cancer trials currently underway, Mayo Clinic demonstrates its commitment to finding new treatments and solutions for this challenging disease. Although they have only recorded two liver cancer trials thus far, their first trial was initiated as recently as 2018.
Another prominent hospital making significant strides in liver cancer research is Memorial Sloan Kettering Cancer Center in New york City. Currently conducting eight active trials, this esteemed institution has already completed an impressive 28 studies dedicated to liver cancer since embarking on its first trial back in 2003.
In Houston, M D Anderson Cancer Center also stands out with eight ongoing clinical trials focused specifically on liver cancer. They have a history of conducting 14 previous studies since recording their inaugural trial for this condition in 2002.
Meanwhile, Washington University School of Medicine in Saint Louis has made notable contributions to the field as well. This prestigious institution currently has six active clinical trials dedicated to advancing our understanding and treatment options for patients with liver cancer. Since starting their first trial related to this disease in 2002, they have completed a total of eight investigations.
Lastly, but certainly not least important is Massachusetts General Hospital Cancer Center based out of Boston which conducts five current research endeavors pertaining solely towards avoiding fatal impacts caused by Liver Cancers; while theirs can be traced only around recent years from beginning it's primary live-trial experimentations dating back till year 2001 they've managed successfully accomplish six such tests all-time
These hospitals represent beacons of hope and progress for those affected by liver cancer worldwide. Through their relentless dedication and tireless efforts within countless scientific breakthroughs being achieved every day; these medical centers truly symbolize inspiration proving that even the most challenging diseases can be overcome one step at a time
Which are the best cities for liver cancer clinical trials?
Boston, Massachusetts; Los Angeles, California; Houston, Texas; New york, New York; and Chicago, Illinois emerge as the top cities for liver cancer clinical trials. These locations offer individuals access to cutting-edge research with a wide range of active trials studying various treatments such as Pembrolizumab, Nivolumab, Ipilimumab, Atezolizumab, and more. With 26 active trials in Boston and 21 each in Los Angeles and Houston, these cities stand out as hotspots for liver cancer research. Additionally, New York City and Chicago contribute to this important field with 20 and 18 ongoing trials respectively. From coast to coast across the United States these cities provide hope through innovative approaches in the fight against liver cancer.
Which are the top treatments for liver cancer being explored in clinical trials?
The pursuit of effective liver cancer treatments is ongoing, with several promising options currently being explored in clinical trials. Pembrolizumab stands out as a frontrunner, with four active trials and six all-time liver cancer trials since its introduction in 2016. Atezolizumab and durvalumab are also making strides, each involved in three active trials and five all-time liver cancer trials (atezolizumab listed in 2020 and durvalumab listed the same year). Additionally, a pharmacological study holds promise with two active trials and three all-time liver cancer trials since its initiation back in 2008. These advancements bring hope to patients living with this challenging disease as researchers continue their dedicated efforts towards finding new treatment avenues.
What are the most recent clinical trials for liver cancer?
Exciting advancements are being made in the realm of liver cancer research, with recent clinical trials exploring novel treatments and combinations. One such trial is investigating Arm 1, a comprehensive approach to combat liver cancer that encompasses both Phase 2 and Phase 3 studies. Additionally, regorafenib has shown promise as a potential treatment option for liver cancer patients, while durvalumab plus tremelimumab is being evaluated in a Phase 3 trial. Another study focuses on the combination of zimberelimab and domvanalimab in treating this challenging condition. These latest developments bring hope to individuals affected by liver cancer, highlighting the ongoing efforts to improve treatment outcomes and quality of life for patients.
What liver cancer clinical trials were recently completed?
Several clinical trials exploring potential treatments for liver cancer have recently reached completion, highlighting advancements in this field. In August 2020, Celldex Therapeutics concluded a trial investigating the efficacy of CDX-527. Additionally, the National Cancer Institute wrapped up their study on nivolumab in June 2019. Another notable trial was conducted by Celldex Therapeutics and focused on CDX-1140; it was completed in December 2017. These developments showcase the ongoing efforts to find effective therapies for liver cancer and provide hope for patients facing this challenging disease.