Corticosteroid
Lidocaine + Steroid Injections for Migraines
This trial aims to investigate if injecting lidocaine and steroids into two blood vessels in the brain can help treat chronic migraines. The study will assess the safety and effectiveness of this treatment for chronic migraine
Procedure
Intravenous Fluids for Childhood Migraine
This trial is comparing different amounts of fluids given through an IV to children with migraines. The trial wants to find out if giving a large amount of fluids quickly can help reduce pain and prevent hospital admissions
Behavioural Intervention
High-Fat Meal Effects on Cardiovascular Risk in Women with Migraine
This trial is testing the effects of a high-fat, high-carbohydrate meal on various cardiovascular disease risk factors in young women with and without migraine, comparing obese and normal weight women in each group.
Behavioural Intervention
Auricular Acupuncture for Migraines
This trial compares ear acupuncture and standard IV medications for treating migraines in children in the emergency room. Ear acupuncture uses needles in the ear to change nerve signals and reduce pain, while standard treatments use drugs to relieve symptoms.
Behavioural Intervention
EMG Biofeedback for Chronic Pain
This trial is testing a device that helps people relax their muscles. It targets patients with chronic low back pain, those undergoing mastectomy or lumpectomy, and those with episodic migraines. The goal is to see if this device can help reduce their pain and improve their overall well-being.
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Trials for MA Patients
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Emotional Awareness and Expression Therapy for Migraine
This trial tests a new therapy called Emotional Awareness and Expression Therapy (EAET) for people with migraines. EAET helps individuals recognize and express difficult emotions to reduce stress and emotional pain. The goal is to see if this therapy can lower the frequency and severity of migraine attacks.
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Trials for Headache Patients
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Nerve Stimulator
Wearable Nerve Stimulation for Migraines and Mood Disorders
This trial tests a wrist-worn nerve stimulator to see if it can reduce pain, anxiety, depression & sleep disruption in adolescents with chronic headaches & mood trouble. Participants wear device & complete monthly surveys for 12 weeks.
Phase 3 Trials
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Monoclonal Antibodies
Erenumab for Migraine
This trial tests if erenumab, an injection given regularly, can reduce migraine days in children and adolescents with chronic migraines by blocking a protein that triggers these headaches. Erenumab has been shown to reduce migraine days and improve quality of life in adults with chronic and episodic migraines.
Trials With No Placebo
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Emotional Awareness and Expression Therapy for Migraine
This trial tests a new therapy called Emotional Awareness and Expression Therapy (EAET) for people with migraines. EAET helps individuals recognize and express difficult emotions to reduce stress and emotional pain. The goal is to see if this therapy can lower the frequency and severity of migraine attacks.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Behavioral Intervention
Online Intervention for Migraines
This trial is testing whether an online intervention can help improve headache outcomes for adolescents with migraines, compared to an attention control intervention. The primary outcome will be the number of headache days, assessed via online daily diary pre- and post-intervention.
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Frequently Asked Questions
Introduction to migraine
What are the top hospitals conducting migraine research?
When it comes to cutting-edge research and clinical trials for migraine, several top hospitals are leading the way. In Bellevue, Washington, the Northwest Clinical Research Center stands out with an impressive 12 ongoing migraine trials and a total of 37 completed trials in their history. This facility has been dedicated to studying migraines since recording its first trial in 2014. Meanwhile, Clinvest Research LLC in Springfield is making significant contributions as well with nine active migraine trials and a previous record of 17 conducted studies since initiating their inaugural trial in 2018.
Moving east to Cincinnati, Ohio, the Cincinnati Children's Hospital Medical Center is at the forefront of pediatric migraine research. With eight ongoing clinical trials focused on migraines and a total of 13 previously conducted studies since their first recorded trial in 2012, this hospital plays a critical role in advancing our understanding of this condition among children.
In Stamford, Connecticut, the New England Institute for Clinical Research is actively involved in investigating new treatments for migraines. They currently have eight active migraine trials underway and have completed a commendable sixteen studies since conducting their initial trial also back in 2012.
Not far away from Stamford lies Boston Clinical Trials where another group of medical professionals are diligently working on finding solutions for those affected by migraines. With eight ongoing clinical trials and twenty-three completed investigations under their belt dating back to their first recorded trial in 2015,
All these hospitals demonstrate dedication towards unraveling mysteries surrounding migraines through cutting-edge research approaches across different regions within the United States.With every step forward taken by these esteemed institutions brings us closer toward advancements that could potentially transform countless lives affected by this debilitating condition worldwide
Which are the best cities for migraine clinical trials?
When it comes to migraine clinical trials, several cities have emerged as hubs for cutting-edge research. Miami, Florida leads the pack with 45 active trials investigating promising treatments such as Lasmiditan, Ubrogepant, and Rimegepant / BHV3000. Cincinnati, Ohio closely follows with 38 ongoing studies exploring treatments like Rimegepant / BHV3000, Ubrogepant, and Fremanezumab. Amherst, New york also plays a significant role in migraine research with 26 active trials focusing on therapies such as Fremanezumab, Eptinezumab, and Rimegepant / BHV3000. These cities offer individuals suffering from migraines access to state-of-the-art clinical trials that pave the way for improved treatment options and quality of life.
Which are the top treatments for migraine being explored in clinical trials?
The field of migraine treatment is constantly evolving, and clinical trials are at the forefront of exploring new possibilities. Eptinezumab has emerged as a top contender with four active trials and 12 all-time migraine trials since its introduction in 2019. Fremanezumab is also proving promising, currently being tested in three ongoing trials following its listing in 2016. Additionally, Emotional Awareness and Expression Therapy (EAET) shows potential with two active trials slated for this innovative approach introduced recently in 2023. Rimegepant / BHV3000 rounds out the list with two active trials examining its effectiveness against migraines since being listed in 2021. As research progresses, these treatments offer hope for improved management and relief from the debilitating effects of migraines.
What are the most recent clinical trials for migraine?
Exciting advancements in migraine treatment have emerged from recent clinical trials. One of them involves atogepant, which has shown promise in Phase 3 trials as a potential therapy for migraines. Additionally, ReMMiD-C Therapeutic Arm A and eptinezumab 300 mg have both demonstrated positive results in Phase 3 trials, offering hope for improved migraine management. Another trial focused on the use of greater occipital nerve blocks to alleviate migraines shows encouraging potential during its Phase 2 stage. These findings provide renewed optimism for individuals seeking effective solutions to manage their migraines and improve their quality of life.
What migraine clinical trials were recently completed?
Several recent clinical trials have made significant strides in the field of migraine treatment. March 2022 saw the completion of a trial sponsored by Allergan, which investigated the effectiveness of Ubrogepant. In December 2021, Eli Lilly and Company concluded their study on Galcanezumab, while H. Lundbeck A/S wrapped up their trial on Lu AG09222 in November 2021. Other completed trials include Dihydroergotamine (June and September 2021), Fremanezumab-Vfrm (December 2020), THC ~5% and CBD ~12% (November 2020), LY3451838 (November 2020), Erenumab-Aooe (October 2020) – all with various sponsors ranging from pharmaceutical companies to academic institutions. These advancements offer hope for individuals living with migraines by expanding our understanding of potential treatments for this debilitating condition.