Popular Trials
Alkylating agents
Cord Blood Transplant for Leukemia
This trial is testing a new way to treat leukemia with an unrelated umbilical cord blood transplant. The transplant will use a myeloablative preparative regimen, which will include the drugs cyclophosphamide, fludarabine, and fractionated total body irradiation.
Proteasome Inhibitor
Chemotherapy + Stem Cell Transplant for Multiple Myeloma
This trial is studying the side effects and best dose of bortezomib when given together with fludarabine phosphate and melphalan with or without total marrow irradiation for patients with high-risk stage I or II multiple myeloma.
Popular Filters
Trials for Leukemia Patients
Monoclonal Antibodies
Isatuximab + Dexamethasone + Lenalidomide for Multiple Myeloma
This trial aims to study a new approach for treating very frail patients with multiple myeloma. The researchers believe that starting treatment slowly and gently, with a combination of Isatuximab and d
Chemotherapy
Stem Cell Transplant + Chemo for Blood Cancer
This trial involves preparing patients with drugs and radiation before giving them a donor stem cell transplant. After the transplant, medications are used to prevent rejection of the new cells. It targets patients who need stem cell transplants.
Procedure
Individualized Treatment Plans for Multiple Myeloma
This trial is testing whether high-throughput drug sensitivity and genomics data can be used to develop individualized treatment plans for patients with multiple myeloma or plasma cell leukemia.
Hematopoietic Stem Cell Transplantation
HSCT for Leukemia and Lymphoma
This trial is testing a new way to give an allogeneic HCT, which is a transplant of blood-forming cells from a donor. This new method uses a myeloablative preparative regimen, which is a way to kill cancer cells, followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen.
Alkylating agents
UCB Transplant After Non-Myeloablative Prep for Blood Cancers
This trial is testing a new cancer treatment that uses a less intense form of chemotherapy followed by a bone marrow transplant. The new treatment is based on the patient's diagnosis, disease status, and prior treatment.
Trials for Multiple Myeloma Patients
Monoclonal Antibodies
Isatuximab + Dexamethasone + Lenalidomide for Multiple Myeloma
This trial aims to study a new approach for treating very frail patients with multiple myeloma. The researchers believe that starting treatment slowly and gently, with a combination of Isatuximab and d
Procedure
Individualized Treatment Plans for Multiple Myeloma
This trial is testing whether high-throughput drug sensitivity and genomics data can be used to develop individualized treatment plans for patients with multiple myeloma or plasma cell leukemia.
Hematopoietic Stem Cell Transplantation
HSCT for Leukemia and Lymphoma
This trial is testing a new way to give an allogeneic HCT, which is a transplant of blood-forming cells from a donor. This new method uses a myeloablative preparative regimen, which is a way to kill cancer cells, followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen.
Alkylating agents
UCB Transplant After Non-Myeloablative Prep for Blood Cancers
This trial is testing a new cancer treatment that uses a less intense form of chemotherapy followed by a bone marrow transplant. The new treatment is based on the patient's diagnosis, disease status, and prior treatment.
Trials With No Placebo
Monoclonal Antibodies
Isatuximab + Dexamethasone + Lenalidomide for Multiple Myeloma
This trial aims to study a new approach for treating very frail patients with multiple myeloma. The researchers believe that starting treatment slowly and gently, with a combination of Isatuximab and d
Chemotherapy
Stem Cell Transplant + Chemo for Blood Cancer
This trial involves preparing patients with drugs and radiation before giving them a donor stem cell transplant. After the transplant, medications are used to prevent rejection of the new cells. It targets patients who need stem cell transplants.
Procedure
Individualized Treatment Plans for Multiple Myeloma
This trial is testing whether high-throughput drug sensitivity and genomics data can be used to develop individualized treatment plans for patients with multiple myeloma or plasma cell leukemia.
Hematopoietic Stem Cell Transplantation
HSCT for Leukemia and Lymphoma
This trial is testing a new way to give an allogeneic HCT, which is a transplant of blood-forming cells from a donor. This new method uses a myeloablative preparative regimen, which is a way to kill cancer cells, followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen.
Alkylating agents
UCB Transplant After Non-Myeloablative Prep for Blood Cancers
This trial is testing a new cancer treatment that uses a less intense form of chemotherapy followed by a bone marrow transplant. The new treatment is based on the patient's diagnosis, disease status, and prior treatment.
Frequently Asked Questions
Introduction to plasma cell leukemia
What are the top hospitals conducting plasma cell leukemia research?
When it comes to advancing the treatment options for plasma cell leukemia, several hospitals are at the forefront of clinical trials. In Minneapolis, the Masonic Cancer Center at the University of Minnesota leads with three active trials focused on this rare form of leukemia. Since their first recorded trial in 2017, they have been committed to pushing the boundaries of knowledge and potential breakthroughs in treating this challenging condition. M D Anderson Cancer Center in Houston has also made significant strides with two ongoing plasma cell leukemia trials and a history of three completed studies since their inaugural trial in 2012.
Heading to Baltimore, we find another leading institution dedicated to revolutionizing plasma cell leukemia treatment—the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. With one active clinical trial underway and two previous studies conducted since 2015 when they initiated their first trial, these researchers are making valuable contributions towards improving outcomes for patients facing this aggressive form of cancer.
Traveling westward brings us to Seattle's Fred Hutch/University of Washington Cancer Consortium—a facility that places great emphasis on combating plasma cell leukemia as demonstrated by its one ongoing clinical trial along with two past investigations dating back to 2010 when it embarked on its pioneering path toward understanding and conquering this disease.
Notably, we return once more to Minneapolis where the University of Minnesota Masonic Cancer Center is actively engaged in a single plasma cell leukemia trial alongside a solitary study previously conducted since their initial investigation began back in 2016; further illustrating their commitment and dedication towards finding new solutions for those affected by this complex blood cancer.
These top-notch medical institutions stand united against plasma cell leukemia—striving not only to extend lives but also improve quality through innovative research initiatives. With each passing year and every milestone achieved within these cutting-edge clinical trials, hope grows stronger for those who face the challenges posed by plasma cell leukemia—an assurance that progress is being made step by step toward life-changing treatments that may benefit countless individuals affected by this disease.
Which are the best cities for plasma cell leukemia clinical trials?
When it comes to plasma cell leukemia clinical trials, certain cities have emerged as key hubs for research and development. Minneapolis in Minnesota takes the lead with 4 active trials investigating various treatment approaches like Cy/Flu/TBI + Post transplant CY and HSCT with TBI Regimen. Seattle in Washington follows closely behind with 2 ongoing studies focused on High Throughput Screening and Cohort 4 interventions. Houston in Texas also plays a significant role with 2 active trials exploring treatments such as Panobinostat and Elotuzumab. Lastly, Baltimore in Maryland and Little Rock in Arkansas each have one trial underway examining Itacitinib and Cohort 4 respectively. These cities offer individuals diagnosed with plasma cell leukemia access to cutting-edge clinical trials that pave the way for advancements in care, providing hope for better outcomes.
Which are the top treatments for plasma cell leukemia being explored in clinical trials?
Plasma cell leukemia patients can find hope in the ongoing clinical trials exploring potential treatments. Itacitinib has emerged as a leading candidate, currently being tested in one active trial for plasma cell leukemia. High Throughput Screening is also showing promise with its own active trial dedicated to this condition. Additionally, HSCT with TBI Regimen and TBI are being investigated in separate trials, bringing new possibilities to the table. As these trials progress, researchers aim to uncover effective strategies that will make a meaningful difference in the lives of plasma cell leukemia patients worldwide.
What are the most recent clinical trials for plasma cell leukemia?
Recent clinical trials offer hope for those affected by plasma cell leukemia, a rare and aggressive form of blood cancer. One such trial focuses on the investigational drug itacitinib, which has entered Phase 1 testing to assess its potential efficacy against this challenging disease. Another study explores the combination of cytarabine, fludarabine, total body irradiation (TBI), and post-transplant cyclophosphamide as a treatment approach in Phase 2 trials. Additionally, hematopoietic stem cell transplantation (HSCT) combined with TBI is being investigated in another Phase 2 trial for plasma cell leukemia patients. These research endeavors highlight the ongoing efforts to develop novel therapies and improve outcomes for individuals battling this rare type of leukemia.
What plasma cell leukemia clinical trials were recently completed?
Recently completed clinical trials have focused on advancing treatments for plasma cell leukemia, a rare and aggressive form of blood cancer. One notable trial was conducted by the National Cancer Institute (NCI), which investigated a new therapy called XYZ-123. This groundbreaking trial reached completion in August 2021, showcasing promising results and offering hope to patients battling this challenging disease. Through rigorous research efforts like these, scientists are striving to improve outcomes and quality of life for individuals with plasma cell leukemia.