Popular Trials
Biguanide
Metformin for Prediabetes
This trial is testing whether metformin can lower the risk of death, heart attacks, and strokes in people with pre-diabetes and heart or blood vessel issues. Metformin is a drug that helps control blood sugar levels and has been used to treat type 2 diabetes mellitus for more than 60 years. The study involves patients who have pre-diabetes and existing heart or blood vessel problems, aiming to see if metformin can provide additional health benefits.
Behavioral Intervention
Heat Therapy for Prediabetes
This trial aims to determine if using heat pads on the legs can improve muscle health, physical function, and blood sugar control in older individuals with prediabetes as effectively as High-Intensity Interval Training (
Hormone Therapy
Insulin Management for Non-alcoholic Fatty Liver Disease
"This trial aims to study the effects of lowering insulin levels on liver glucose production and fat synthesis in individuals with insulin resistance and fatty liver disease. Participants will undergo two procedures with different insulin levels to compare the
Behavioural Intervention
Time-Restricted Eating for Type 2 Diabetes
This trial studies the effects of timing of eating on blood sugar in those with obesity and type 2 diabetes. Participants are assigned a 4-12hr eating window with no restrictions on the food they eat. Results will compare 3 9hr windows to determine if start and stop time impacts blood sugar.
Popular Filters
Trials for Metabolic Syndrome Patients
Potassium Channel Activator
Diazoxide for Non-alcoholic Fatty Liver Disease
This trial will compare 2 doses of diazoxide to placebo to see how they affect glucose and fat metabolism in people with IR-NAFLD. Participants will take 27 doses, have fasting blood tests and wear a glucose monitor for 14 days.
Sodium-glucose cotransporter 2 (SGLT2) inhibitor
Empagliflozin for Prediabetes
This trial is testing whether the drug empagliflozin can help improve regulation of blood sugar in overweight or obese adults with prediabetes. They will also be looking at possible mechanisms to explain how empagliflozin might improve metabolism in skeletal muscle.
Behavioral Intervention
Exercise Training for Fat Metabolism in Postmenopausal Women
This trial will study how well resistance training improves fat metabolism in postmenopausal women with obesity and pre-diabetes, to see if it could help prevent type 2 diabetes.
Behavioral Intervention
Quality Improvement and Implementation Science for Mental and Physical Health in Women Veterans
This trial is testing two strategies to help support and sustain evidence-based practices for women Veterans in up to 20 VA facilities.
Trials for Obesity Patients
Sodium-glucose cotransporter 2 (SGLT2) inhibitor
Empagliflozin for Prediabetes
This trial is testing whether the drug empagliflozin can help improve regulation of blood sugar in overweight or obese adults with prediabetes. They will also be looking at possible mechanisms to explain how empagliflozin might improve metabolism in skeletal muscle.
Behavioral Intervention
Exercise Training for Fat Metabolism in Postmenopausal Women
This trial will study how well resistance training improves fat metabolism in postmenopausal women with obesity and pre-diabetes, to see if it could help prevent type 2 diabetes.
Behavioral Intervention
Quality Improvement and Implementation Science for Mental and Physical Health in Women Veterans
This trial is testing two strategies to help support and sustain evidence-based practices for women Veterans in up to 20 VA facilities.
Behavioural Intervention
Lifestyle Intervention for Preventing Type 2 Diabetes
This trial aims to study a new program to prevent type 2 diabetes in adults in the US. The program focuses on lifestyle changes and support from romantic partners to create long-lasting effects.
Trials With No Placebo
Behavioral Intervention
Small Steps for Big Changes Program for Prediabetes
This trial evaluates the effectiveness of the 'Small Steps for Big Changes' (SSBC) program, designed to help people with prediabetes improve their diet and exercise habits. The goal is to see if these changes can lower blood sugar levels, reduce weight, and decrease waist size over time. Participants receive personalized guidance and support from trainers at YMCA locations. The 'Small Steps for Big Changes' (SSBC) program emphasizes behavior change techniques and motivational interviewing to help adults at risk for type 2 diabetes.
Behavioral Intervention
Exercise Training for Fat Metabolism in Postmenopausal Women
This trial will study how well resistance training improves fat metabolism in postmenopausal women with obesity and pre-diabetes, to see if it could help prevent type 2 diabetes.
Behavioral Intervention
Quality Improvement and Implementation Science for Mental and Physical Health in Women Veterans
This trial is testing two strategies to help support and sustain evidence-based practices for women Veterans in up to 20 VA facilities.
View More Related Trials
Frequently Asked Questions
Introduction to prediabetes
What are the top hospitals conducting prediabetes research?
When it comes to cutting-edge clinical trials aimed at combating prediabetes, several top hospitals are leading the charge. Columbia University Irving Medical Center in New york is at the forefront of this research, currently conducting three active trials focused on prediabetes. While their all-time tally stands at just three, their commitment to exploring this condition is evident as they recorded their first trial in 2022.
The University of Kentucky in Lexington is also making significant strides with three ongoing prediabetes trials and two completed studies under their belt. Since initiating their first trial in 2020, they have been dedicated to advancing our understanding of prediabetes and finding novel approaches for prevention and treatment.
On the southeastern side of the United States, Florida State University in Tallahassee has joined the efforts by actively conducting two prediabetes trials while having accomplished a total of three since recording its initial investigation back in 2015. Their contributions play an essential role within this field.
Over on the West Coast, specifically located within West Los Angeles, CA., the VA Greater Los Angeles Healthcare System has taken up the mantle with two active prediabetes trials under its belt along with previous completion upon initiation achieved through another pair beginning from2021 onwards; though relatively new compared to other facilities mentioned here but showcasing impressive progress nonetheless.
And lastly,the Durham VA Medical Center situated in Durham,North carolina might not appear as extensive numerically when it comes down towards active or previously held experiments focusing on tackling Prediabetic scenarios,but nevertheless stands no less commendable being amongst those contributing valuable data through undertaking around two current investigations along with one earlier conducted; successfully commencing only recently itself during year 2023
These hospitals exemplify dedication towards addressing and understanding a growing concern worldwide -prediabetes- offering hope for individuals who may be at risk and reinforcing our collective pursuit of comprehensive preventive strategies that can potentially lead us toward healthier futures
Which are the best cities for prediabetes clinical trials?
When it comes to prediabetes clinical trials, several cities emerge as leaders in research and development. New york City boasts 9 active trials focusing on interventions like Diazoxide oral suspension, Metformin XR, and the Reduction toward euinsulinemia (RE) protocol. Birmingham, Alabama follows closely behind with 6 ongoing studies exploring treatments such as Metformin therapy and the Abbott Freestyle Libre 2 system. Baltimore, Maryland and San Antonio,Texas each have 5 active trials investigating various interventions including Metformin XR, HTD1801, Semaglutide, and lifestyle modifications. Lastly, Lexington,Kentucky hosts four active trials studying interventions such as Mirabegron and Metformin XR. These cities offer individuals with prediabetes access to cutting-edge clinical research that may pave the way for improved preventive measures against diabetes onset.
Which are the top treatments for prediabetes being explored in clinical trials?
The search for effective treatments for prediabetes is ongoing, with several potential options being explored in clinical trials. Empagliflozin, a newcomer to the field since its listing in 2022, has already garnered attention with two active trials dedicated specifically to prediabetes. Metformin, a well-known player in diabetes management, also shows promise with two active trials and an impressive history of 31 all-time prediabetes studies since its introduction in 2010. In addition to drug-based approaches, intervention-based treatments are gaining traction as well, as evidenced by two ongoing clinical trials focused on addressing prediabetes through lifestyle modifications or other non-pharmaceutical methods. As researchers delve deeper into these avenues of exploration, they bring us one step closer to finding effective interventions for those at risk of developing type 2 diabetes.
What are the most recent clinical trials for prediabetes?
Exciting developments are underway in the field of prediabetes research, with recent clinical trials offering potential breakthroughs for early intervention and treatment. One promising trial is focused on the Reduction toward euinsulinemia (RE) protocol, which aims to address prediabetes through innovative strategies. Another study explores the use of Diazoxide oral suspension as a potential therapy for individuals with prediabetes. Additionally, ongoing Phase 2 trials are assessing various treatments including ADI-PEG20 and Metformin XR to determine their effectiveness in managing this condition. These studies provide hope for individuals at risk of developing type 2 diabetes by identifying novel approaches that could help prevent or delay its onset.
What prediabetes clinical trials were recently completed?
Recently, there have been notable advancements in the field of prediabetes research through the completion of significant clinical trials. In October 2020, Indiana University concluded a trial examining the potential use of Antidepressant Medications for this condition. Furthermore, Mayo Clinic completed a trial investigating Exenatide SR in May 2019. These studies represent important steps forward in understanding and treating prediabetes, offering hope for individuals at risk of developing type 2 diabetes and guiding future interventions to prevent its progression.