Popular Trials
Memantine for Cognitive Impairment in SLE
Recruiting0 awardsPhase 2
Nashville, Tennessee
This trial is testing memantine, a drug that blocks certain brain receptors, in people with Systemic Lupus Erythematosus (SLE) who have a specific genetic variant. The goal is to see if memantine can safely and effectively reduce cognitive symptoms in these patients. Memantine is used to treat memory and thinking problems and has been investigated for similar issues in SLE patients.
Mucolytic Agent
N-acetylcysteine for Lupus
Recruiting0 awardsPhase 2
Syracuse, New York
This trial is a phase II study to test the safety and efficacy of N-acetyl cysteine (NAC) in treating systemic lupus erythematosus (SLE). SLE is a chronic inflammatory disease which often has debilitating and potentially life-threatening consequences. The cause of SLE is unknown and current therapies lack specificity and carry significant side-effects. This study will have two groups of 105 subjects each, with one group continuing the tolerated dosage of NAC and the other group switched to placebo capsules. The study will last 13 months with seven study visits per subject. Each subject will donate approximately 100 ml of blood
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Trials for Lupus Patients
Behavioral Intervention
Pain Exposure Therapy for Fibromyalgia
Recruiting1 award
Ann Arbor, Michigan
This trial aims to determine if a short online treatment using Zoom can assist adults with fibromyalgia in learning helpful methods for managing pain, disability, and other associated issues like depression or anxiety.
Monoclonal Antibodies
PF-06823859 for Systemic Lupus Erythematosus
Recruiting0 awardsPhase 2
Oshawa, Ontario
This trial is researching if a drug, PF-06823859, is safe and effective for adults with CLE or SLE and skin symptoms. 48 participants will receive active study medicine or placebo for 65 weeks of study.
Mobile App Intervention for Childhood-Onset Lupus
Recruiting1 award
Bronx, New York
This trial aims to see if a custom mobile app can help young people with lupus stay engaged in their medical care and manage depression. The study focuses on adolescents and young adults from the Bronx, ages 15-24. The app offers personalized support to help them keep up with health appointments and improve their mood.
Cenerimod for Systemic Lupus Erythematosus
Recruiting1 awardPhase 3
Baytown, Texas
This trial is testing cenerimod, a medication aimed at reducing symptoms of Systemic Lupus Erythematosus (SLE) in adults with moderate to severe symptoms. Researchers want to see if cenerimod can help when added to existing treatments. The medication works by calming the overactive immune system, which may reduce inflammation and other symptoms.
Trials for SLE Patients
Behavioral Intervention
Pain Exposure Therapy for Fibromyalgia
Recruiting1 award
Ann Arbor, Michigan
This trial aims to determine if a short online treatment using Zoom can assist adults with fibromyalgia in learning helpful methods for managing pain, disability, and other associated issues like depression or anxiety.
Monoclonal Antibodies
PF-06823859 for Systemic Lupus Erythematosus
Recruiting0 awardsPhase 2
Oshawa, Ontario
This trial is researching if a drug, PF-06823859, is safe and effective for adults with CLE or SLE and skin symptoms. 48 participants will receive active study medicine or placebo for 65 weeks of study.
Mobile App Intervention for Childhood-Onset Lupus
Recruiting1 award
Bronx, New York
This trial aims to see if a custom mobile app can help young people with lupus stay engaged in their medical care and manage depression. The study focuses on adolescents and young adults from the Bronx, ages 15-24. The app offers personalized support to help them keep up with health appointments and improve their mood.
Cenerimod for Systemic Lupus Erythematosus
Recruiting1 awardPhase 3
Baytown, Texas
This trial is testing cenerimod, a medication aimed at reducing symptoms of Systemic Lupus Erythematosus (SLE) in adults with moderate to severe symptoms. Researchers want to see if cenerimod can help when added to existing treatments. The medication works by calming the overactive immune system, which may reduce inflammation and other symptoms.
Trials for ANA Positive Patients
CAR T-cell Therapy
Rapcabtagene Autoleucel for Lupus Nephritis
Recruiting1 awardPhase 2
Chicago, Illinois
"This trial aims to compare the effectiveness and safety of rapcabtagene autoleucel with the standard treatment in patients with lupus and kidney inflammation that has not responded to standard treatment."
Monoclonal Antibodies
Belimumab for Lupus
Recruiting1 awardPhase 2
Phoenix, Arizona
This trial is testing a medication called belimumab, given as an injection under the skin, in children with lupus. The goal is to see if it is safe and effective by calming down their overactive immune systems. Belimumab is approved for the treatment of lupus in adults with moderate disease activity.
Janus Kinase (JAK) Inhibitor
Deucravacitinib for Lupus
Recruiting1 awardPhase 3
La Jolla, California
This trial is testing a new medication called deucravacitinib to see if it is safe and effective for people with moderate to severe lupus, a disease where the immune system attacks the body. The medication aims to reduce inflammation by targeting specific enzymes in the immune system.
Deucravacitinib for Lupus
Recruiting1 awardPhase 3
Denver, Colorado
This trial is testing a new medication called deucravacitinib to see if it can help people with moderate to severe Systemic Lupus Erythematosus (SLE). The medication works by calming down the immune system and reducing inflammation. The goal is to find out if it is safe and effective for these patients.
Monoclonal Antibodies
Obinutuzumab for Lupus
Recruiting1 awardPhase 3
Fullerton, California
This trial is testing a medication called obinutuzumab in people with active lupus who have specific antibodies in their blood. These patients are already on standard treatments but need more help. The medication works by reducing harmful immune cells that cause inflammation and damage.
Trials for Anti-dsDNA Positive Patients
CAR T-cell Therapy
Rapcabtagene Autoleucel for Lupus Nephritis
Recruiting1 awardPhase 2
Chicago, Illinois
"This trial aims to compare the effectiveness and safety of rapcabtagene autoleucel with the standard treatment in patients with lupus and kidney inflammation that has not responded to standard treatment."
Monoclonal Antibodies
Belimumab for Lupus
Recruiting1 awardPhase 2
Phoenix, Arizona
This trial is testing a medication called belimumab, given as an injection under the skin, in children with lupus. The goal is to see if it is safe and effective by calming down their overactive immune systems. Belimumab is approved for the treatment of lupus in adults with moderate disease activity.
Janus Kinase (JAK) Inhibitor
Deucravacitinib for Lupus
Recruiting1 awardPhase 3
La Jolla, California
This trial is testing a new medication called deucravacitinib to see if it is safe and effective for people with moderate to severe lupus, a disease where the immune system attacks the body. The medication aims to reduce inflammation by targeting specific enzymes in the immune system.
Monoclonal Antibodies
Obinutuzumab for Lupus
Recruiting1 awardPhase 3
Fullerton, California
This trial is testing a medication called obinutuzumab in people with active lupus who have specific antibodies in their blood. These patients are already on standard treatments but need more help. The medication works by reducing harmful immune cells that cause inflammation and damage.
Upadacitinib for Lupus
Recruiting1 awardPhase 3
Flagstaff, Arizona
This trial will assess if upadacitinib is a safe and effective treatment for SLE. 500 people will take part in this trial globally, taking either upadacitinib or a placebo in 3 sub-studies. Regular visits & assessments to check the effect of the treatment will be done.
Phase 3 Trials
Cenerimod for Systemic Lupus Erythematosus
Recruiting1 awardPhase 3
Baytown, Texas
This trial is testing cenerimod, a medication aimed at reducing symptoms of Systemic Lupus Erythematosus (SLE) in adults with moderate to severe symptoms. Researchers want to see if cenerimod can help when added to existing treatments. The medication works by calming the overactive immune system, which may reduce inflammation and other symptoms.
Litifilimab for Lupus
Recruiting1 awardPhase 3
Upland, California
This trial is testing a new drug for Lupus called BIIB059. The goal is to see if it is effective in reducing disease activity, and if it has any other benefits compared to placebo. There are many secondary objectives to this study, including assessing the safety and immunogenicity of the drug.
Anti-malarial drug
Stopping Hydroxychloroquine for Lupus
Recruiting1 awardPhase 3
Los Angeles, California
This trial is testing if older lupus patients can safely stop taking Hydroxychloroquine, a drug that reduces lupus symptoms but can harm the eyes over time. The study focuses on patients aged 60 and above who have stable disease. Researchers will monitor these patients for an extended period to see if their condition remains stable without the drug.
Janus Kinase (JAK) Inhibitor
Deucravacitinib for Lupus
Recruiting1 awardPhase 3
La Jolla, California
This trial is testing a new medication called deucravacitinib to see if it is safe and effective for people with moderate to severe lupus, a disease where the immune system attacks the body. The medication aims to reduce inflammation by targeting specific enzymes in the immune system.
Trials With No Placebo
Behavioral Intervention
Pain Exposure Therapy for Fibromyalgia
Recruiting1 award
Ann Arbor, Michigan
This trial aims to determine if a short online treatment using Zoom can assist adults with fibromyalgia in learning helpful methods for managing pain, disability, and other associated issues like depression or anxiety.
Mobile App Intervention for Childhood-Onset Lupus
Recruiting1 award
Bronx, New York
This trial aims to see if a custom mobile app can help young people with lupus stay engaged in their medical care and manage depression. The study focuses on adolescents and young adults from the Bronx, ages 15-24. The app offers personalized support to help them keep up with health appointments and improve their mood.
View More Related Trials
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.