Dr. Anne M McKenzie-Brown, MD

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Studies HIV Infection
Studies Peripheral Neuropathic Pain
1 reported clinical trial
1 drug studied

Clinical Trials Anne M McKenzie-Brown, MD is currently running

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Low Dose Naltrexone

for Pain in HIV/AIDS

The increased life expectancy of Patients Living With HIV/AIDS (PLWHA) has increased the need for therapies for chronic conditions, such as chronic pain. Pain in the HIV population is often refractory and ends up being treated with chronic opioids, which are associated with adverse effects, including hyperalgesia, constipation, and risk of overdose. Naltrexone is an opioid antagonist used in the treatment of alcohol and opioid use disorders. Low Dose Naltrexone (LDN), naltrexone at a much lower dose, is thought to be an immune modulator and has been associated with an increased CD4 count in PLWHA. Repurposing this medication is relatively inexpensive and has the potential to expand access to treatment for a painful condition experienced in PLWHA. While there are many case reports on the efficacy of LDN in symptom reduction, there are only a small number of clinical trials that specifically examine pain and symptom relief. This study will include patients who are not completely virologically controlled and will monitor the CD4 counts drawn as a part of routine care. If the CD4 count improves with LDN and with reduced symptoms, this could be a significant improvement in HIV therapy for symptom control. There have been studies showing cytokine reduction in fibromyalgia patients but they did not investigate the correlation with cytokines and pain relief. This study involves repurposing a drug used for substance use disorder to a medication with the potential to treat pain and improve symptoms for PLWHA.
Recruiting3 awards Phase 46 criteria

More about Anne M McKenzie-Brown, MD

Clinical Trial Related1 year of experience running clinical trials · Led 1 trial as a Principal Investigator · 1 Active Clinical Trial
Treatments Anne M McKenzie-Brown, MD has experience with
  • Low Dose Naltrexone
Breakdown of trials Anne M McKenzie-Brown, MD has run
HIV Infection
Peripheral Neuropathic Pain
Pregnancy Immune Function
Lymphoma
Neuropathic Pain

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Frequently asked questions

Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Anne M McKenzie-Brown, MD specialize in?
Anne M McKenzie-Brown, MD focuses on HIV Infection and Peripheral Neuropathic Pain. In particular, much of their work with HIV Infection has involved treating patients, or patients who are undergoing treatment.
Is Anne M McKenzie-Brown, MD currently recruiting for clinical trials?
Yes, Anne M McKenzie-Brown, MD is currently recruiting for 1 clinical trial in the USA. If you're interested in participating, you should apply.
Are there any treatments that Anne M McKenzie-Brown, MD has studied deeply?
Yes, Anne M McKenzie-Brown, MD has studied treatments such as Low Dose Naltrexone.
What is the best way to schedule an appointment with Anne M McKenzie-Brown, MD?
Apply for one of the trials that Anne M McKenzie-Brown, MD is conducting.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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