Dr. Helen M Bronte-Stewart, MD MSE
Claim this profileStanford University
Studies Dementia
Studies Parkinson's Disease
3 reported clinical trials
3 drugs studied
Affiliated Hospitals
Clinical Trials Helen M Bronte-Stewart, MD MSE is currently running
Closed Loop DBS
for Parkinson's Disease
Deep Brain Stimulation of the subthalamic nucleus (STN) has become a standard of care, FDA-approved treatment for Parkinson's disease, with stimulation delivered at a constant amplitude and voltage, operating in an open-loop fashion that does not respond to a patient's current state. Although gait deficits and freezing of gait may initially respond to continuous open-loop deep brain stimulation (olDBS) and medication, the symptoms often recur over time. The episodic and predictable nature of FOG makes it well suited for adaptive DBS (aDBS) and a device that overcomes the limitations of traditional high frequency olDBS and is capable of adapting therapy either in the frequency or intensity domain transiently to treat FOG while also treating other PD signs such as tremor and bradykinesia. The purpose of this study is to determine the feasibility of an adaptive DBS system, that responds to patient-specific neural and kinematic variables with customized DBS parameters.
Recruiting1 award N/A7 criteria
STN+NBM DBS
for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor symptoms in individuals with Parkinson's disease. The main question it aims to answer is: Is a combined deep brain stimulation approach targeting the STN and NBM with four DBS leads safe and tolerable for cognitive and cognitive-motor symptoms in individuals with Parkinson's disease with Mild Cognitive Impairment. Ten participants are anticipated to be enrolled. Participants will undergo a modification of the traditional STN DBS approach for motor symptoms of PD. In addition to the two leads placed within the STN, two additional leads will be placed with the NBM for treatment of cognitive and cognitive-motor symptoms. Novel stimulation patterns will be used within the NBM to target cognitive and cognitive-motor symptoms using an investigational software. Participants will be followed over two years while receiving this therapy with assessments at baseline and every six months. Assessments will include a combination of neuropsychological evaluations, cognitive assessments, motor tasks (including gait/walking), and questionnaires to evaluate the treatment. Two different surgical trajectories will be used, with half the cohort randomized to each group. This will allow comparison of the impact of surgical trajectory on the intervention.
Recruiting1 award N/A
More about Helen M Bronte-Stewart, MD MSE
Clinical Trial Related5 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Helen M Bronte-Stewart, MD MSE has experience with
- Bilateral Closed Loop Deep Brain Stimulation
- Adaptive DBS
- Combined STN+NBM DBS
Breakdown of trials Helen M Bronte-Stewart, MD MSE has run
Dementia
Parkinson's Disease
Mild Cognitive Impairment
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Helen M Bronte-Stewart, MD MSE specialize in?
Helen M Bronte-Stewart, MD MSE focuses on Dementia and Parkinson's Disease. In particular, much of their work with Dementia has involved treating patients, or patients who are undergoing treatment.
Is Helen M Bronte-Stewart, MD MSE currently recruiting for clinical trials?
Yes, Helen M Bronte-Stewart, MD MSE is currently recruiting for 2 clinical trials in Stanford California. If you're interested in participating, you should apply.
Are there any treatments that Helen M Bronte-Stewart, MD MSE has studied deeply?
Yes, Helen M Bronte-Stewart, MD MSE has studied treatments such as Bilateral Closed Loop Deep Brain Stimulation, Adaptive DBS, Combined STN+NBM DBS.
What is the best way to schedule an appointment with Helen M Bronte-Stewart, MD MSE?
Apply for one of the trials that Helen M Bronte-Stewart, MD MSE is conducting.
What is the office address of Helen M Bronte-Stewart, MD MSE?
The office of Helen M Bronte-Stewart, MD MSE is located at: Stanford University, Stanford, California 94305 United States. This is the address for their practice at the Stanford University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.