Dr. Joshua Sasine, MD, PhD
Claim this profileCedars-Sinai Medical Center
Affiliated Hospitals
Cedars-Sinai Medical Center
Clinical Trials Joshua Sasine, MD, PhD is currently running
Cyclophosphamide After Stem Cell Transplant
for Blood Cancer
The purpose of this phase 1 study is to determine the optimal dose of the immune suppressive drug, cyclophosphamide, following standard allogeneic stem cell transplant in patients aged \>/= 65 years with hematologic malignancies.
Recruiting
1 award
Phase 1
Stem Cell + CAR T-Cell Therapy
for Blood Cancers
The study is designed to examine the feasibility and safety of collecting autologous hematopoietic stem cells (HSCs) to be combined with CAR T-cell therapy for patients with relapsed/refractory (r/r) hematological disease. The study will evaluate feasibility of collecting the target dose of HSCs from at least 50% of enrolled patients. The study will assess safety based on incidence and severity of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) in the first 60 days post CAR T dosing, and also through the collection of adverse events (AEs) and serious adverse events (SAEs) as well as the durability of response after treatment with HSCs with CAR T. The study follows an open-label, single-center and single non-randomized cohort design. 20 subjects with r/r hematological malignancies will be enrolled and treated to evaluate the feasibility and preliminary safety of collecting autologous HSCs and combining them with CAR T-cell therapy.
Recruiting
1 award
Phase 1
11 criteria
More about Joshua Sasine, MD, PhD
Clinical Trial Related
2 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Joshua Sasine, MD, PhD has experience with
- Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy
- Cyclophosphamide
Breakdown of trials Joshua Sasine, MD, PhD has run
Cancer
Blood Cancers
Multiple Myeloma
Diffuse Large B-Cell Lymphoma
Acute Lymphoblastic Leukemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Joshua Sasine, MD, PhD specialize in?
Joshua Sasine, MD, PhD focuses on Cancer and Blood Cancers. In particular, much of their work with Cancer has involved treating patients, or patients who are undergoing treatment.
Is Joshua Sasine, MD, PhD currently recruiting for clinical trials?
Yes, Joshua Sasine, MD, PhD is currently recruiting for 2 clinical trials in Los Angeles California. If you're interested in participating, you should apply.
Are there any treatments that Joshua Sasine, MD, PhD has studied deeply?
Yes, Joshua Sasine, MD, PhD has studied treatments such as Autologous Hematopoietic Stem Cells with Chimeric Antigen Receptor (CAR) T-Cell Therapy, Cyclophosphamide.
What is the best way to schedule an appointment with Joshua Sasine, MD, PhD?
Apply for one of the trials that Joshua Sasine, MD, PhD is conducting.
What is the office address of Joshua Sasine, MD, PhD?
The office of Joshua Sasine, MD, PhD is located at: Cedars-Sinai Medical Center, Los Angeles, California 90048 United States. This is the address for their practice at the Cedars-Sinai Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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