Dr. Nancy D Chiaravalloti, PhD
Claim this profileKessler Foundation Research Center
Affiliated Hospitals
Kessler Foundation Research Center
Clinical Trials Nancy D Chiaravalloti, PhD is currently running
Memory Training
for Mild Cognitive Impairment
The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in individuals with Mild Cognitive Impairment (MCI). Impairment in higher level cognitive processing, such as new learning and memory, is one of the most common deficits in individuals with MCI and such deficits have been shown to exert significant negative impact on multiple aspects of everyday life, including occupational and social functioning. Despite these findings, few studies have attempted to treat these cognitive deficits in order to improve the everyday functioning of individuals with MCI. Through a small randomized clinical trial, the investigators found that individuals with MCI with documented cognitive impairment show a significant improvement in their memory performance following a treatment protocol designed to facilitate learning. The current proposal will replicate this finding and further evaluate (a) the impact of the treatment on everyday functioning, (b) the long term efficacy of the treatment and (c) the utility of booster sessions in facilitating long-term treatment effects. We will randomly assign older individuals who meet criteria for a diagnosis of amnestic MCI to a memory retraining group or a placebo control group. Both groups will undergo baseline, immediate and long-term follow-up assessment consisting of: (1) a traditional neuropsychological battery, (2) an assessment of global functioning examining the impact of the treatment on daily activities, and (3) functional neuroimaging. This design will allow the investigators to evaluate the efficacy of this particular memory retraining technique in an aMCI population through the assessment of cognitive function via a standard evaluation. In addition, the investigators will be able to draw conclusions regarding the impact of this particular memory remediation program on everyday life from questionnaires completed by the participant and a significant other. Optional enrollment in pre- post neuroimaging will also allow the investigators to look at changes in the brain.
Recruiting
0 awards
N/A
3 criteria
Combinatory Rehabilitation
for Traumatic Brain Injury
New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g. story) as well as beneficial changes in default-mode network (DMN) activation during list-learning19 following treatment with the Kessler Foundation modified Story Memory Technique® (KF-mSMT®). Benefits, however, were moderate and did not yield downstream improvements in daily life. It is thus critical to examine other approaches to complement the KF-mSMT® for robustly managing NLMI in TBI. The proposed RCT will be the first to include aerobic exercise training (AET) as a highly-promising complement to the KF-mSMT® for robustly managing NLMI, examining impact on NLM, its neural correlates, and daily life in NLM impaired persons with moderate-to-severe TBI. We thus propose a two-arm, parallel group, double-blind RCT comparing the effects of the KF-mSMT+AET with the KF-mSMT+S/T (active control condition) on NLM (Aim 1), hippocampal MRI (Aim 2), and daily life outcomes (Aim 3). 60 NLM impaired persons with moderate-to-severe TBI will be randomized to one of 2 conditions (30 per condition). Each condition will take place 3 days per week for 12 weeks and will be supervised by KF personnel. Participants will be blinded as to the intent of the conditions. We will further explore baseline predictors of clinically meaningful changes in NLM for those completing the KF-mSMT + AET condition (Exploratory Aim 4). If successful, this trial will position combinatory KF-mSMT and AET within the clinician's arsenal for robustly managing NLMI in persons with TBI. By augmenting the effects of KF-mSMT with AET, this treatment aims to exert a powerful countermeasure to TBI-related NLMI, and ultimately help those with TBI-related NLMI return to the workforce, independently manage their everyday lives, and maintain optimal quality of life. Additionally, while rigorously designed to answer the scientific question of the relative benefit of AET with the KF-mSMT, the proposed study is will likely provide some level of benefit to all study participants. If successful, this trial will provide Class I evidence of combined KF-mSMT and AET for rehabilitating NLMI in TBI, based on standards published for therapeutic trials by the American Academy of Neurology, thus positioning such an approach within the clinician's arsenal for robustly managing NLMI. By augmenting the effects of KF-mSMT with AET, we anticipate this treatment will ultimately help those with TBI-related NLMI return to the workforce, independently manage their everyday lives, and maintain optimal quality of life.
Recruiting
1 award
Phase 1
More about Nancy D Chiaravalloti, PhD
Clinical Trial Related
2 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Nancy D Chiaravalloti, PhD has experience with
- Placebo Control Exercises
- Strategy-Based Training To Enhance Memory (STEM)
- KF-mSMT Plus Aerobic Exercise Training
- KF-mSMT Plus Stretching Exercise Training
- Memory Retraining Exercises
- Placebo Control Memory Exercises
Breakdown of trials Nancy D Chiaravalloti, PhD has run
Multiple Sclerosis
Traumatic Brain Injury
Cognitive Impairment
Mild Cognitive Impairment
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Nancy D Chiaravalloti, PhD specialize in?
Nancy D Chiaravalloti, PhD focuses on Multiple Sclerosis and Traumatic Brain Injury. In particular, much of their work with Multiple Sclerosis has involved treating patients, or patients who are undergoing treatment.
Is Nancy D Chiaravalloti, PhD currently recruiting for clinical trials?
Yes, Nancy D Chiaravalloti, PhD is currently recruiting for 2 clinical trials in West Orange New Jersey. If you're interested in participating, you should apply.
Are there any treatments that Nancy D Chiaravalloti, PhD has studied deeply?
Yes, Nancy D Chiaravalloti, PhD has studied treatments such as Placebo control exercises, Strategy-Based Training to Enhance Memory (STEM), KF-mSMT Plus Aerobic Exercise Training.
What is the best way to schedule an appointment with Nancy D Chiaravalloti, PhD?
Apply for one of the trials that Nancy D Chiaravalloti, PhD is conducting.
What is the office address of Nancy D Chiaravalloti, PhD?
The office of Nancy D Chiaravalloti, PhD is located at: Kessler Foundation Research Center, West Orange, New Jersey 07052 United States. This is the address for their practice at the Kessler Foundation Research Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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