Dr. Priya U. Kumthekar
Claim this profileNorthwestern University
Studies Glioblastoma
Studies Brain Cancer
12 reported clinical trials
44 drugs studied
Area of expertise
1Glioblastoma
IDH negative
MET negative
MGMT
2Brain Cancer
IDH negative
Stage IV
MET negative
Affiliated Hospitals
Clinical Trials Priya U. Kumthekar is currently running
Ultrasound-assisted Chemotherapy
for Glioblastoma
Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion with albumin-bound paclitaxel. In the phase 1 component, increasing doses of chemotherapy will be delivered as long deemed safe based on the prior patient not experiencing severe toxicity. Once the the recommended dosing has been established, carboplatin will be added to the regimen and additional patients will be treated in order to better evaluate the antitumor efficacy of this novel treatment. The device will be implanted at the time of surgical resection of the recurrent tumor. During that procedure and when feasible, a first test dose of the chemotherapy will be administered in the operating room after sonication (procedure of activating ultrasound and opening the BBB) and tissue concentrations in different parts of the resected tumor will be measured. In select patients, the sonication procedure may occur immediately after the test dose of chemotherapy is administered. The objectives of this trial are to establish a safe and effective dose of albumin-bound paclitaxel, to demonstrate that the opening of the BBB increases chemotherapy concentration in the tumor, and to estimate how effective this treatment is in reducing the tumor burden and prolonging life.
Recruiting3 awards Phase 1 & 219 criteria
Targeted Therapy
for Brain Cancer
This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several genes have been found to be altered or mutated in brain metastases such as NTRK, ROS1, CDK, PI3K, or KRAS G12C. Medications that target these genes such as abemaciclib, paxalisib, entrectinib and adagrasib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Genetic testing may help doctors tailor treatment for each mutation.
Recruiting1 award Phase 217 criteria
More about Priya U. Kumthekar
Clinical Trial Related4 years of experience running clinical trials · Led 12 trials as a Principal Investigator · 9 Active Clinical TrialsTreatments Priya U. Kumthekar has experience with
- Radiation Therapy
- Bevacizumab
- Nivolumab
- Capivasertib
- Vismodegib
- Abemaciclib
Breakdown of trials Priya U. Kumthekar has run
Glioblastoma
Brain Cancer
Brain Tumor
Relapse
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Priya U. Kumthekar specialize in?
Priya U. Kumthekar focuses on Glioblastoma and Brain Cancer. In particular, much of their work with Glioblastoma has involved IDH negative patients, or patients who are MET negative.
Is Priya U. Kumthekar currently recruiting for clinical trials?
Yes, Priya U. Kumthekar is currently recruiting for 9 clinical trials in Chicago Illinois. If you're interested in participating, you should apply.
Are there any treatments that Priya U. Kumthekar has studied deeply?
Yes, Priya U. Kumthekar has studied treatments such as Radiation Therapy, Bevacizumab, Nivolumab.
What is the best way to schedule an appointment with Priya U. Kumthekar?
Apply for one of the trials that Priya U. Kumthekar is conducting.
What is the office address of Priya U. Kumthekar?
The office of Priya U. Kumthekar is located at: Northwestern University, Chicago, Illinois 60611 United States. This is the address for their practice at the Northwestern University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.