Dr. Victoria E Claydon, PhD

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Simon Fraser University

Studies Vasovagal Syncope
Studies Postural Orthostatic Tachycardia Syndrome
3 reported clinical trials
5 drugs studied

Affiliated Hospitals

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Simon Fraser University

Clinical Trials Victoria E Claydon, PhD is currently running

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Blood Phobia Impact on Fainting

for

The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia \[needle phobia\]) during an orthostatic (upright) challenge in individuals with and without known needle phobia. It is well established that emotional stress can produce hypotensive (low blood pressure) reactions. Interestingly, these hypotensive reactions to venipuncture (even with minimal blood drawn), insulin injections, finger sticks for blood sugar monitoring, dental care, and vaccinations can affect up to a quarter of adults and appear to be uniquely associated with blood-injection-injury phobia rather than other phobias. These hypotensive reactions can ultimately lead to a vasovagal syncope (fainting) response, and lead to increased avoidance of medical and dental procedures as a result of this phobia. Ultimately, this has severe implications on public health and places additional strain on the Canadian healthcare system. Currently, there is limited understanding surrounding the initiation of this response. Additionally, a comprehensive profile of cardiovascular autonomic function during exposure to provoking stimuli during orthostatic stress has not been captured in the literature. We will test individuals with and without blood-injection-injury phobia using our standard approach while exposing them to emotional stimuli.

Recruiting

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N/A

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Counterpressure Maneuvers

for Fainting

The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.

Recruiting

0 awards

N/A

3 criteria

More about Victoria E Claydon, PhD

Clinical Trial Related

1 year of experience running clinical trials · Led 3 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Victoria E Claydon, PhD has experience with

  • Baseline Stand
  • Counterpressure Maneuvers
  • Water Carbonation
  • Blood-injection-injury (BII) Phobia Stimuli
  • Neutral Stimuli

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