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Carbonated Water for Orthostatic Hypotension

N/A

Recruiting

Led By Victoria E Claydon, PhD

Research Sponsored by Simon Fraser University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Must not have

History of cardiovascular disease

History of neurological disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0-50 minutes

Awards & highlights

No Placebo-Only Group

Summary

This trial investigates if carbonated water can help people maintain normal blood pressure when standing, so they don't faint or feel dizzy.

Who is the study for?

This trial is for healthy, English-speaking individuals without a history of cardiovascular or neurological diseases, not pregnant, and who haven't fainted more than once in the past six months. It's designed to see if carbonated water helps people maintain blood pressure when standing up.

What is being tested?

The study tests whether drinking 500mL of carbonated water improves orthostatic tolerance—the ability to keep blood pressure stable when standing—compared to the same amount of still water. A smaller volume (50mL) of still water serves as an additional control.

What are the potential side effects?

There are no significant side effects expected from consuming carbonated or still water in this trial; however, some individuals might experience mild gastrointestinal discomfort due to gas from the carbonation.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a history of heart disease.

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I have a history of a neurological condition.

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I have fainted at least twice in the last 6 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0-50 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0-50 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-50 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Orthostatic tolerance

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

6Treatment groups

Experimental Treatment

Group I: 50mL still water first, then 500mL still water, then 500 mL carbonated waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 50mL still water on the first test day, 500mL carbonated water on the second test day, then 500mL carbonated water on the third day.

Group II: 50mL still water first, then 500mL carbonated water, then 500 mL still waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 50mL still water on the first test day, 500mL still water on the second test day, then 500mL still water on the third day.

Group III: 500mL still water first, then 50mL still water, then 500 mL carbonated waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL still water on the first test day, 50mL still water on the second test day, then 500mL carbonated water on the third day.

Group IV: 500mL still water first, then 500 mL carbonated water, then 50mL still waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL still water on the first test day, 500mL carbonated water on the second test day, then 50mL still water on the third day.

Group V: 500mL carbonated water first, then 50mL of still water, then 500mL of still waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL carbonated water on the first test day, 50mL still water on the second test day, then 500mL still water on the third day.

Group VI: 500mL carbonated water first, then 500mL of still water, then 50mL of still waterExperimental Treatment3 Interventions

Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL carbonated water on the first test day, 500mL still water on the second test day, then 50mL still water on the third day.

0 / 3Eligibility criteria met