Your session is about to expire
Pepcid vs Rolaids
Introduction
For patients experiencing discomfort from heartburn or acid indigestion, certain medications that can alter the acidity levels in the stomach can help alleviate these symptoms. Pepcid and Rolaids are two such drugs often used for this purpose. They each work differently to manage gastric acid secretions but both aim to provide relief from discomfort due to excessive stomach acidity. Pepcid is a type of medication known as an H2 antagonist which works by blocking histamine at the receptors of acid-producing cells; this reduces production of stomach acid giving more time for damaged esophageal tissue to heal. Rolaids, on the other hand, is classified as an antacid that contains calcium carbonate and magnesium hydroxide. It works primarily by neutralizing existing excess stomach acid quickly after ingestion providing fast relief.
Pepcid vs Rolaids Side By Side
| Attribute | Pepcid | Rolaids |
|---|---|---|
| Brand Name | Pepcid | Rolaids |
| Contraindications | Should not be taken with certain types of drugs without doctor's advice, including ketoconazole, tetracycline, iron supplements, or any prescription medication for Parkinson's disease. | Should not be used continuously for longer than two weeks without medical advice. Persistent symptoms warrant medical evaluation. |
| Cost | Approximately $0.67/day for brand name, $0.15 to $0.50 per day for generic | Approximately $0.07/day for brand name, less than $0.05/day for generic |
| Generic Name | Famotidine | Calcium carbonate and magnesium hydroxide |
| Most Serious Side Effect | Rapid or irregular heartbeat, hallucinations or confusion, unusual bleeding or bruising, jaundice, allergic reactions such as rashes, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing | Signs of an allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue or throat, unusual changes in mood or behavior, confusion or anxiety, severe dizziness or a spinning sensation (vertigo), a tremor, fast, slow or irregular heartbeats, bloody stools and/or cloudy urine |
| Severe Drug Interactions | Ketoconazole, tetracycline, iron supplements, prescription medications for Parkinson's disease | Can interact with certain medications, always discuss all medications you're taking with your doctor before starting a new one. |
| Typical Dose | 20-40mg/day for adults and adolescents, lower doses for children under 12 or those who weigh less than 40 kg | 2 to 4 tablets, chewed and swallowed as symptoms occur, can be repeated every hour if needed or as directed by a doctor. Maximum daily intake is 16 tablets for adults under 60 and 8 tablets for adults over 60. |
What is Pepcid?
Famotidine (the generic name for Pepcid) is a histamine-2 blocker, which serves to reduce the amount of acid produced by the stomach. It was first approved by the FDA in 1986. Famotidine is prescribed primarily for gastric and peptic ulcers, gastroesophageal reflux disease (GERD), and conditions where the stomach produces excessive amounts of acid like Zollinger-Ellison syndrome. On the other hand, Rolaids are antacids that work on contact with gastric acids to neutralize them immediately providing quick relief from heartburn or indigestion caused by excess stomach acid. Unlike Pepcid which acts on receptors in the stomach lining to decrease new production of acid at its source, Rolaids does not lower production but instead counteracts existing acidity levels through an alkaline effect brought about by its key ingredients: calcium carbonate and magnesium hydroxide.
What conditions is Pepcid approved to treat?
Pepcid is approved for the treatment of various conditions related to excess stomach acid:
- Gastroesophageal reflux disease (GERD), also known as heartburn
- Gastric and duodenal ulcers
- Conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome.
How does Pepcid help with these illnesses?
Pepcid helps manage symptoms of heartburn by reducing the amount of acid produced in the stomach. It accomplishes this by blocking histamine-2, which stimulates the secretion of gastric acid. This reduction in stomach acidity can alleviate discomfort and pain associated with conditions like gastroesophageal reflux disease (GERD) and ulcers. Stomach acid plays a critical role in digestion but excessive amounts or its backflow into the esophagus can lead to inflammation, discomfort, and damage to the digestive tract lining. Therefore, by inhibiting histamine-2 receptors on gastric parietal cells, Pepcid decreases acid production helping patients manage their condition and reduce their symptoms.
On comparison, Rolaids is an over-the-counter antacid that works differently than Pepcid. Instead of reducing future production of stomach acids like Pepcid does through H2 blockers; Rolaids neutralizes existing excess stomach acid upon intake providing immediate relief from heartburn symptoms. This makes it suitable for dealing with acute episodes rather than long-term management.
What is Rolaids?
Rolaids is a brand name for an over-the-counter antacid that contains calcium carbonate and magnesium hydroxide. It works by neutralizing stomach acid to provide relief from heartburn, acid indigestion, and sour stomach. Rolaids was first introduced in 1954 and has since become a household name for fast-acting relief against gastric discomfort.
In contrast to Pepcid (famotidine), which belongs to the class of drugs known as H2 blockers that reduce the production of stomach acid, Rolaids acts directly on existing stomach acid to neutralize it. Its dual-action formula combines two active ingredients: Calcium carbonate helps in treating heartburn while magnesium hydroxide assists with rapid acid neutralization.
Although rare, some side effects can include constipation or diarrhea. However, unlike Pepcid which may take longer to work but provides more lasting relief, Rolaids generally works quickly—within minutes—to alleviate symptoms of heartburn and indigestion.
What conditions is Rolaids approved to treat?
Rolaids, an over-the-counter antacid, is approved for use in the treatment of:
- Heartburn or acid indigestion
- Sour stomach associated with these conditions
It functions by neutralizing stomach acid and providing fast relief from discomfort.
How does Rolaids help with these illnesses?
Calcium and magnesium are essential minerals that play roles in many processes in the body, regulating muscle function, nerve transmission, blood clotting, and heart health. An imbalance or deficiency of these minerals can lead to various health issues such as heartburn or acid indigestion. Rolaids works by neutralizing stomach acid through its active ingredients - calcium carbonate and magnesium hydroxide- thereby alleviating some of the symptoms associated with heartburn and indigestion. Its action on neutralizing excess stomach acid may also explain why it's effective at providing rapid relief from these discomforts. Since Rolaids doesn't inhibit production of stomach acids like Pepcid (an H2 antagonist), it is often chosen for immediate relief when a patient experiences sudden episodes of heartburn or requires quick acting remedy for indigestion.
How effective are both Pepcid and Rolaids?
Both famotidine (Pepcid) and calcium carbonate/magnesium hydroxide (Rolaids) have established histories of success in managing symptoms of heartburn, indigestion, and acid reflux. These two medications were approved by the FDA several years apart with Pepcid being approved first. As they act through different mechanisms within the gastrointestinal system to neutralize or reduce stomach acid, they may be recommended under different circumstances.
The effectiveness of Pepcid as a histamine-2 blocker to reduce stomach acid was directly studied in numerous clinical trials since its introduction in the 1980s; it exhibited efficacy in managing symptoms related to excess stomach acid such as heartburn as well as a safe profile when used appropriately. On the other hand, Rolaids operates differently - instead of reducing production of stomach acid like Pepcid does, Rolaids is an antacid that works by neutralizing existing stomach acid. Clinical studies have shown this can provide quick relief for occasional heartburn and indigestion.
A review based on multiple reports has demonstrated that famotidine is effective at providing longer-lasting relief from symptoms compared to traditional antacids like Rolaids but may take slightly longer initially to start working. Famotidine has also been shown to be safe for use even among elderly populations who often deal with chronic conditions requiring various treatments.
Like all medicines though, both drugs should only be taken after consultation with a healthcare provider and understanding potential side effects which might include constipation or diarrhea more commonly seen with Rolaids usage due its direct interaction with gastric acids.
While comparing these two medications' efficacy against each other would depend on individual patient factors including severity and frequency of their condition whether it's severe GERD or mild occasional gastritis/indigestion episodes among others alongwith what they prefer between immediate symptom relief vs long-term control.
Related trials for pepcid and rolaids
Find Top Clinical Trials
Choose from over 30,000 active clinical trials.
At what dose is Pepcid typically prescribed?
Oral dosages of Pepcid for adults and adolescents range from 20-40mg/day, but studies have shown that a dosage of 20mg/day is usually effective in managing stomach acid production. Children under the age of 12 or those who weigh less than 40 kg may be started on lower doses as directed by their healthcare provider. If there is no response after several weeks, then the dosage can be increased gradually up to a maximum dose of 40 mg per day. However, it's important not to exceed this daily limit unless specifically instructed by your doctor.
At what dose is Rolaids typically prescribed?
Rolaids treatment typically begins with a dosage of 2 to 4 tablets, chewed and swallowed as symptoms occur. This dose can be repeated every hour if needed or as directed by a doctor. The maximum daily intake is 16 tablets for adults under the age of 60 and 8 tablets for adults over the age of 60. It's important to note that Rolaids should not be used continuously for longer than two weeks unless instructed by a healthcare professional. Persistent symptoms warrant medical evaluation.
What are the most common side effects for Pepcid?
Common side effects associated with Pepcid include:
- Headache
- Dizziness
- Constipation or diarrhea
- Nausea and vomiting
Whereas, Rolaids might cause:
- Nausea
- Loss of appetite
- Constipation
- Dry mouth or increased thirst
- Altered taste sense
While both medications are used to treat heartburn and indigestion, they have differing active ingredients which can lead to different side effects. Always consult your healthcare provider for the best treatment option for you.
Are there any potential serious side effects for Pepcid?
While Pepcid and Rolaids are often used interchangeably to treat heartburn, they can occasionally cause adverse effects. Specifically for Pepcid, the following symptoms could be a sign of serious issues:
- Rapid or irregular heartbeat
- Hallucinations or confusion
- Unusual bleeding or bruising
- Jaundice (yellowing of the skin or eyes)
- Allergic reactions such as rashes, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
For Rolaids on the other hand, you should watch out for these possible side effects:
- Kidney problems: Symptoms may include changes in urine volume/output, pink/bloody/cloudy urine, extreme fatigue/weakness.
- High calcium/magnesium levels: This might lead to symptoms like constipation, loss of appetite, nausea/vomiting.
As always if any severe discomfort persists consult with your healthcare provider immediately.
What are the most common side effects for Rolaids?
Rolaids, an antacid commonly used to neutralize stomach acid and relieve heartburn or indigestion, may have the following side effects:
- Dry mouth
- Increased thirst
- Stomach cramps or upset stomach
- Constipation
- Metallic taste in the mouth
- Bone pain (with long-term use) While these are generally mild and rare, any persistent symptoms should be reported to your healthcare provider. It's important to note that Rolaids can interact with certain medications, so always discuss all medications you're taking with your doctor before starting a new one.
Are there any potential serious side effects for Rolaids?
Rolaids, while generally safe and effective for most people, can occasionally lead to some serious side effects. These may include:
- Signs of an allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Unusual changes in mood or behavior
- Confusion or anxiety
- Severe dizziness or a spinning sensation (vertigo)
- A tremor (uncontrollable shaking)
- Fast, slow or irregular heartbeats
- Bloody stools and/or cloudy urine If you experience any of these symptoms after taking Rolaids, seek immediate medical attention.
Contraindications for Pepcid and Rolaids?
Both Pepcid and Rolaids, like most other antacid medications, might cause some digestive or abdominal discomfort in a few individuals. If you notice your indigestion symptoms worsening after these medications, such as an increase in stomach pain or irregular bowel movements, please consult with your healthcare provider immediately.
Neither Pepcid nor Rolaids should be taken if you are taking certain types of drugs without the advice of a doctor. This especially includes ketoconazole, tetracycline, iron supplements or any prescription medication for Parkinson's disease. Always inform your physician about all the medications you are using; some medicines may require a period to clear from the system to prevent dangerous interactions with Pepcid and Rolaids.
How much do Pepcid and Rolaids cost?
For the brand name versions of these drugs:
- The price for 30 tablets of Pepcid (20 mg) averages around $20, which works out to approximately $0.67/day.
- The cost for a bottle of 72 Rolaids Extra Strength tablets is about $5, working out to roughly $0.07/day.
Thus, if you are taking one tablet per day as needed for relief from heartburn with Pepcid, it would be more costly compared to Rolaids on a per-day treatment basis. However, it's important to remember that cost should not be your primary consideration in determining which drug is right for you.
For the generic versions of Pepcid (famotidine) and Rolaids (calcium carbonate/magnesium hydroxide), costs can vary but are generally lower:
- Famotidine is available in packs starting from 10 up to 200 tablets with approximate costs ranging between $0.15 and $0.50 per day depending on the pack size.
- Generic forms of calcium carbonate/magnesium hydroxide can start at prices as low as around $3 for a pack of 150 chewable tablets - this works out at less than $0.05/day if used regularly.
Popularity of Pepcid and Rolaids
Famotidine, available in generic form as well as under brand names such as Pepcid, is a type of medication known as an H2 antagonist which helps reduce the production of stomach acid. It was estimated that about 3.7 million prescriptions were filled for famotidine in the United States in 2020. Famotidine accounted for roughly 10% of all H2 antagonist prescriptions last year; its usage has been relatively steady over the past decade.
Calcium carbonate and magnesium hydroxide, commonly sold under the brand name Rolaids, are antacids used to neutralize stomach acid on contact. While there isn't specific data detailing how many people use Rolaids each year, it's clear that millions rely on over-the-counter antacids like this one to manage symptoms related to heartburn or indigestion. Antacid usage tends to spike during periods of high stress or around major holidays - times when dietary indiscretions can lead to discomfort.
Conclusion
Both Pepcid (famotidine) and Rolaids (calcium carbonate and magnesium hydroxide) are commonly used medications for the treatment of heartburn, acid indigestion, and sour stomach. They have been extensively tested through clinical studies showing their efficacy in providing relief from these symptoms compared to placebo treatments. While both can be beneficial, they operate differently within the body.
Pepcid is a histamine-2 blocker that works by decreasing the amount of acid produced by the stomach. It's often recommended for those who need consistent management of their symptoms over a longer period. On the other hand, Rolaids is an antacid that neutralizes existing stomach acid on contact providing quick but temporary relief from occasional discomfort.
Both medicines are available over-the-counter representing significant savings especially for patients paying out-of-pocket. Both may require some time before noticeable effects kick in with Pepcid generally taking longer due to its mechanism of action.
In terms of side effects, both drugs are usually well-tolerated but can cause minor issues such as constipation or diarrhea with prolonged use. Despite this similarity, it's crucial for users to pay attention to how they feel while using either medication; if any adverse reactions occur or current symptoms worsen after administration they should seek medical help immediately.
Other Trials to Consider
Popular Categories
Popular Guides
Learn More About These Treatments
Refrences
- Netzer, Brabetz‐Höfliger, BrÜndler, Flogerzi, Hüsler, & Halter. (1998, April). Comparison of the effect of the antacid Rennie versus low‐dose H<sub>2</sub>‐receptor antagonists (ranitidine, famotidine) on intragastric acidity. Alimentary Pharmacology & Therapeutics. Wiley.http://doi.org/10.1046/j.1365-2036.1998.00316.x
- COLIN‐JONES, D. G. (1995, April). The role and limitations of H<sub>2</sub>‐receptor antagonist in the treatment of gastro‐oesophageal refrux disease. Alimentary Pharmacology & Therapeutics. Wiley.http://doi.org/10.1111/j.1365-2036.1995.tb00778.x
- Boccia, G., Manguso, F., Miele, E., Buonavolontà, R., & Staiano, A. (2007, June). Maintenance Therapy for Erosive Esophagitis in Children After Healing by Omeprazole: Is It Advisable?. The American Journal of Gastroenterology. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1111/j.1572-0241.2007.01152.x
- Holtmeier, W., Holtmann, G., Caspary, W. F., & Weingärtner, U. (2007, July). On-demand Treatment of Acute Heartburn With the Antacid Hydrotalcite Compared With Famotidine and Placebo. Journal of Clinical Gastroenterology. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/mcg.0b013e31802e7efb