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What is Simbrinza
BrinzolamideThe Generic name of this drug
Treatment SummaryBrimonidine is a medication used to reduce intraocular pressure in patients with glaucoma. It is a third generation alpha-2 adrenergic receptor agonist, meaning it binds to alpha-2 adrenoceptors more selectively than other similar drugs. Brimonidine is also known as Alphagan and Simbrinza and is used topically to treat rosacea in adults under the brand name Mirvaso. It is an effective and safe alternative to beta-blockers for patients with or at risk for cardiopulmonary disease.
Azoptis the brand name
Simbrinza Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Azopt
Brinzolamide
1998
9
Approved as Treatment by the FDA
Brinzolamide, also known as Azopt, is approved by the FDA for 7 uses which include Increased Intra Ocular Pressure (IOP) and Ocular Hypertension .Increased Intra Ocular Pressure (IOP)
Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Timolol
Open Angle Glaucoma (OAG)
Used to treat Open Angle Glaucoma (OAG) in combination with Timolol
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Timolol
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Timolol
Glaucoma
Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol
Open Angle Glaucoma
Used to treat Open Angle Glaucoma (OAG) in combination with Timolol
Effectiveness
How Simbrinza Affects PatientsBrimonidine is a medicine that targets the alpha-2 adrenergic receptor in the body, reducing the risk of certain side effects like low blood pressure and drowsiness. When used in the eyes, it has been shown to reduce intraocular pressure in people with glaucoma, and can reduce redness and inflammation in people with rosacea. Taking brimonidine by mouth can cause a decrease in blood pressure and heart rate, as well as a lengthening of the PR interval on an electrocardiogram. Brimonidine has also been studied for its possible neuroprotective effects, though further research is needed.
How Simbrinza works in the bodyBrimonidine is a drug used to treat glaucoma and rosacea. In the eye, it works by activating alpha-2 adrenoreceptors. This helps reduce the production of aqueous humour and increases uveoscleral outflow. This cutdown in fluid pressure lowers intraocular pressure (IOP). Reducing IOP helps reduce the risk of vision loss from glaucoma. On the skin, brimonidine works by narrowing the small arteries and veins, reducing redness and inflammation.
When to interrupt dosage
The quantity of Simbrinza is contingent upon the diagnosed state, such as Open Angle Glaucoma, facial erythema and Ocular Hypertension. The dosage also relies on the mode of delivery indicated in the table below.Condition
Dosage
Administration
Glaucoma
, 10.0 mg/mL, 1.0 %
, Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic
Open Angle Glaucoma
, 10.0 mg/mL, 1.0 %
, Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic
Ocular Hypertension
, 10.0 mg/mL, 1.0 %
, Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic
inadequate response to monotherapy
, 10.0 mg/mL, 1.0 %
, Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic
Warnings
There are 18 known major drug interactions with Simbrinza.Common Simbrinza Drug Interactions
Drug Name
Risk Level
Description
Ziconotide
Minor
The risk or severity of CNS depression can be increased when Brinzolamide is combined with Ziconotide.
Benzylpenicillin
Moderate
Brinzolamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Haloperidol
Moderate
The serum concentration of Haloperidol can be increased when it is combined with Brinzolamide.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Brinzolamide is combined with Insulin argine.
Insulin aspart
Moderate
The risk or severity of hypoglycemia can be increased when Brinzolamide is combined with Insulin aspart.
Simbrinza Toxicity & Overdose RiskThe amount of brimonidine needed to cause harm in mice is 50mg/kg, and 100mg/kg in rats. If an adult takes too much brimonidine, they may experience low blood pressure, weakness, vomiting, drowsiness, slowed heart rate, breathing problems, low body temperature, and seizures. Treatment for this kind of overdose includes providing supportive care. Reports of overdose in young children have also been seen and can cause similar symptoms. There is no evidence that taking brimonidine during pregnancy or while breastfeeding will cause harm. However, it is not recommended for infants under 2 or for pediatric patients under 18 due to
Simbrinza Novel Uses: Which Conditions Have a Clinical Trial Featuring Simbrinza?
114 active studies are in progress to ascertain the efficacy of Simbrinza in managing Open Angle Glaucoma, inadequately controlled intraocular pressure and Open Angle Glaucoma.Condition
Clinical Trials
Trial Phases
Ocular Hypertension
13 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
Glaucoma
0 Actively Recruiting
Open Angle Glaucoma
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
inadequate response to monotherapy
0 Actively Recruiting
Simbrinza Reviews: What are patients saying about Simbrinza?
5Patient Review
1/31/2022 I'm 75 years old and have tried a lot of different medications. It's important to remember that all medications come with potential side effects. I started using Simbrinza five months ago when my pressure was 37. Now, my pressure is only 15! This medicine is fantastic--it's the best without a doubt. There are no negative side effects for me, just a little bit of blurred vision that goes away after five minutes. I'm very happy now thanks to Simbrinza.
4.7Patient Review
2/22/2019 I had some sensitivity to light and spasms in my eye muscles. It was painful. When I take the medicine, I pinch my tear ducts for five minutes so that I don't taste it at all. Then I sponge my eyes and dry them three times using water and tissues. This removes the remaining preservatives in the Simbitza. Without this method, I can't use it.
4Patient Review
8/5/2016 The side effects didn't last long and this is the only medication I've found that doesn't cause inflammation of the retina. It's very expensive, but worth it to me.
4Patient Review
9/1/2022 Worked well for about three years, but then I developed allergies to the ingredients and started getting mild conjunctivitis and dermatitis.
4Patient Review
3/16/2018 I've been using this medication for five months now to address burning and taste issues related to my eyes.
Patient Q&A Section about simbrinza
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was SIMBRINZA discontinued?
"11% of people taking SIMBRINZA had to stop taking it because of bad reactions. Other reactions that have been reported during clinical trials for the individual components are listed below."
Answered by AI
What is SIMBRINZA eye drops used for?
"This product contains two medications that are used to lower the pressure in the eye for people who have glaucoma or ocular hypertension. By lowering the pressure in the eye, it reduces the risk of vision loss, nerve damage, or blindness."
Answered by AI
Is SIMBRINZA safe to use?
"Simbrinza can make you drowsy. Be careful when driving, operating machinery, or doing other activities that could be dangerous. If you have any of the following symptoms, stop taking Simbrinza and call your doctor immediately: blurred or tunnel vision, eye pain, seeing halos around lights, eye redness, or severe discomfort."
Answered by AI