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What is Aczone
DapsoneThe Generic name of this drug
Treatment SummaryA sulfone is an antibiotic that targets a broad range of bacteria, but is mostly used against Mycobacterium leprae. It works by blocking the production of folic acid in susceptible organisms, similar to the way sulfonamides work. It can also be combined with pyrimethamine to treat malaria.
Dapsoneis the brand name
Aczone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dapsone
Dapsone
1979
46
Effectiveness
How Aczone Affects PatientsDapsone is a medication with anti-inflammatory, antibacterial, and antibiotic properties. It is most commonly used to treat leprosy, malaria, and Pneumocystic carinii pneumonia in AIDS patients. It is quickly and almost completely absorbed by the body when taken orally. It spreads to all parts of the body, but mostly stays in the skin, muscles, liver, and kidneys. Even after stopping treatment, small traces of dapsone may remain in these organs for up to 3 weeks.
How Aczone works in the bodyDapsone works against bacteria and protozoa by blocking their ability to make the chemical dihydrofolic acid. It also has anti-inflammatory effects, although the exact way it works is still not clear.
When to interrupt dosage
The recommended dosage of Aczone is contingent upon the indicated condition, such as moderate Pneumocystis pneumonia, Relapsing Polychondritis and prophylaxis of mild Pneumocystis pneumonia. The measure of dosage may differ as per the approach of delivery (e.g. Gel - Topical or Topical) listed in the table beneath.Condition
Dosage
Administration
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pneumonia, Pneumocystis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pneumonia, Pneumocystis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous dermatitis herpetiformis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Acne Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Drug Resistance
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pemphigus Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Relapsing Polychondritis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Leprosy
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous Systemic Lupus Erythematosus
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Immune thrombocytopenic purpura
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
HIV
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Aczone.Common Aczone Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Dapsone.
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acetophenazine.
Alimemazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Alimemazine.
Aczone Toxicity & Overdose RiskTaking more than the recommended dose of this drug may cause a stuffy nose, fainting, or hallucinations. If necessary, steps should be taken to stabilize the patient's blood pressure.
Aczone Novel Uses: Which Conditions Have a Clinical Trial Featuring Aczone?
Presently, 144 active trials are assessing the potential of Aczone in providing relief from Bullous Systemic Lupus Erythematosus, mild Pneumocystis pneumonia and Immune thrombocytopenic purpura.Condition
Clinical Trials
Trial Phases
HIV
131 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1
Pneumonia, Pneumocystis
2 Actively Recruiting
Phase 3
Bullous dermatitis herpetiformis
0 Actively Recruiting
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
prophylaxis of mild Pneumocystis pneumonia
0 Actively Recruiting
prophylaxis of moderate Toxoplasma gondii encephalitis
0 Actively Recruiting
prophylaxis of mild Toxoplasma gondii encephalitis
0 Actively Recruiting
Immune thrombocytopenic purpura
0 Actively Recruiting
Pemphigus Vulgaris
2 Actively Recruiting
Phase 1
Leprosy
0 Actively Recruiting
Pneumonia, Pneumocystis
0 Actively Recruiting
Bullous Systemic Lupus Erythematosus
0 Actively Recruiting
Toxoplasmosis
0 Actively Recruiting
Acne Vulgaris
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Toxoplasmosis
1 Actively Recruiting
Phase 4
Relapsing Polychondritis
0 Actively Recruiting
Drug Resistance
0 Actively Recruiting
Aczone Reviews: What are patients saying about Aczone?
5Patient Review
6/9/2016 I've only used it for a few days and I can tell the condition of my skin is already improving. I've tried so many acne products, and nothing really has worked-- until now. I have hormonal painful acne and have been struggling with it for the past 2 years. So far, this product has given me great results.
5Patient Review
2/27/2022 Aczone has quickly and effectively cleared up my breakouts, sometimes in just one to two nights. Not only that, but it also doesn't dry out or flake my skin like other treatments I've tried (looking at you, biacna). If you suffer from hormonal cystic acne or regular old breakouts as an adult, do yourself a favor and give this stuff a try.
5Patient Review
2/18/2020 This acne cream is very effective and doesn't dry out my skin. However, it's very expensive. I've been able to find a discount through CarePoint, which is $60 a bottle about 6-8 weeks. My insurance doesn't cover this and estimates my out of pocket cost would be over $2,000 for this drug.
5Patient Review
2/25/2016 Aczone is very effective in halting acne growth. I was really blown away by how well it worked. However, the price tag is pretty hefty at $200-$275 per tube (30 grams). And, once your year of insurance coverage runs out, you're stuck paying that high price unless a generic form becomes available (which thankfully will be in September 2016 when the patent expires).
5Patient Review
3/22/2017 Aczone is the only medication that has worked for me. Not only does it quickly reduce swelling and redness, but blemishes are gone within 1-2 days. I highly recommend this to anyone struggling with breakouts!
5Patient Review
10/12/2015 This was the only treatment that helped my acne.
2.3Patient Review
9/8/20151.7Patient Review
8/12/2017 The smell of this stuff was really off-putting, and it actually bleached my towels when I used them to dry my hands. On top of that, it made the skin on my fingers peel off! Overall, terrible experience with nasty side effects.
1Patient Review
4/25/2017 Aczone is an overpriced and ineffective medication, distributed by the greedy pharmaceutical company Allergan. Save your money and buy a better product that won't cost you an arm and a leg. I'm switching back to Finacea, which is just as good on my skin and doesn't break the bank.
Patient Q&A Section about aczone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Aczone do for skin?
"This medication is used to treat acne by decreasing the number and severity of acne pimples, and also helping pimples that do develop to heal more quickly."
Answered by AI
How long can you use Aczone?
"The recommended treatment time for ACZONE® gel is 12 weeks (3 months). Your doctor will decide if treatment should continue after this time period."
Answered by AI
Is Aczone gel a retinoid?
"The medication Differin is used to treat acne vulgaris and belongs to the drug class called retinoids. Dapsone is a different medication used to treat bacterial infections and belongs to the drug class called antibacterials. A brand name for dapsone is Aczone."
Answered by AI
Does Aczone work for hormonal acne?
"Aczone can be used to treat both facial and body acne. It is most effective for breakouts that are inflammatory, but it can also help treat non-inflammatory breakouts like blackheads and milia."
Answered by AI