Bontril

Exogenous Obesity

Treatment

1 FDA approval

0 Active Studies for Bontril

What is Bontril

Phendimetrazine

The Generic name of this drug

Treatment Summary

Phendimetrazine is a prescription medication used to promote weight loss. It is classified as a Schedule III drug in the US due to its similarity to amphetamines.

Bontril PDM

is the brand name

image of different drug pills on a surface

Bontril Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bontril PDM

Phendimetrazine

1976

79

Approved as Treatment by the FDA

Phendimetrazine, otherwise known as Bontril PDM, is approved by the FDA for 1 uses including Exogenous Obesity .

Exogenous Obesity

Helps manage Exogenous Obesity

Effectiveness

How Bontril Affects Patients

Phendimetrazine is a drug that works like the amphetamines used to treat obesity. It stimulates the central nervous system and raises blood pressure. Over time, the body can become used to the drug and it may not be as effective. These drugs are also called "anorectics" and are thought to help with weight loss by reducing appetite, although other effects on the body may also be involved.

How Bontril works in the body

Phendimetrazine works by activating the body's alpha-adrenergic system, which suppresses appetite and increases metabolism. It also works to release norepinephrine and dopamine. It does this by binding to and reversing the NET, a transport system for these hormones.

When to interrupt dosage

The prescribed measure of Bontril is contingent upon the diagnosed ailment. The amount likewise differs depending on the approach of delivery (e.g. Capsule or Capsule, extended release - Oral) featured in the referenced table.

Condition

Dosage

Administration

Exogenous Obesity

, 35.0 mg, 105.0 mg

, Oral, Tablet, Tablet - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral

Warnings

Bontril has twelve contraindications, thus it should not be ingested if any of the conditions in the table below are present.

Bontril Contraindications

Condition

Risk Level

Notes

Hyperthyroidism

Do Not Combine

Hypertensive disease

Do Not Combine

advanced arteriosclerosis

Do Not Combine

nrevousness

Do Not Combine

symptomatic cardiovascular disease

Do Not Combine

Agitation

Do Not Combine

Hypertension

Do Not Combine

Open-angle glaucoma

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Drug abuse

Do Not Combine

There are 20 known major drug interactions with Bontril.

Common Bontril Drug Interactions

Drug Name

Risk Level

Description

1-benzylimidazole

Minor

The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phendimetrazine.

2,5-Dimethoxy-4-ethylthioamphetamine

Minor

The risk or severity of hypertension can be increased when Phendimetrazine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.

5-methoxy-N,N-dimethyltryptamine

Minor

The risk or severity of hypertension can be increased when Phendimetrazine is combined with 5-methoxy-N,N-dimethyltryptamine.

Abediterol

Minor

The risk or severity of hypertension can be increased when Phendimetrazine is combined with Abediterol.

Acebutolol

Minor

The therapeutic efficacy of Acebutolol can be decreased when used in combination with Phendimetrazine.

Bontril Toxicity & Overdose Risk

Taking too much phendimetrazine can cause restlessness, confusion, aggression, hallucinations, and panic. It can also lead to extreme tiredness and sadness. Heart issues may include abnormal heartbeats, high or low blood pressure, and weak blood circulation. Other symptoms may include nausea, vomiting, diarrhea, and stomach pain. In extreme cases, there may be seizures, unconsciousness, and even death.

image of a doctor in a lab doing drug, clinical research

Bontril Novel Uses: Which Conditions Have a Clinical Trial Featuring Bontril?

No active trials are currently assessing the potential of Bontril to address Exogenous Obesity.

Condition

Clinical Trials

Trial Phases

Exogenous Obesity

0 Actively Recruiting

Bontril Reviews: What are patients saying about Bontril?

5

Patient Review

2/7/2009

Bontril for Overweight

I started this treatment on 9/30/08 and I was 230lbs. Today is 10/7/2008, and I've already lost 7 lbs. This is the first time something has actually worked for me; I'm really happy about it. Remember that this pill is meant for people who are obese, not just looking to lose 10 pounds. My doctor told me that I have to use it for 3 months, then take a break for 1 month, before starting again.

5

Patient Review

6/30/2009

Bontril for Overweight

Bontril has been effective for me in losing weight; however, it also makes me feel very irritable. I think this is because it's a stimulant and those typically increase anxiety. So far, the drug has helped with my weight loss goals despite these side effects.

5

Patient Review

5/21/2010

Bontril for Overweight

I've lost twelve pounds in three weeks thanks to this medication, and I couldn't be happier.

5

Patient Review

10/12/2009

Bontril for Overweight

I saw significant results within two months.

5

Patient Review

11/2/2011

Bontril for Overweight

Bontril was extremely effective for me. I lost 20lbs each of the first two months, and then 10lbs in the third month when I took it every other day.

5

Patient Review

10/28/2010

Bontril for Overweight

Bontril has been a great help to me in losing weight. I'm down 37lbs in just 13 weeks!

5

Patient Review

10/29/2019

Bontril for Weight Loss Management for an Obese Person

Bontril has helped me lose weight quickly and effectively. In less than six months, I went from 235 pounds to 179. My doctor was able to lower my insulin intake from 60 units to 16, and my A1C went from 8.5 to 6.8.

5

Patient Review

10/29/2019

Bontril for Weight Loss Management for an Obese Person

I've lost a substantial amount of weight in a short period of time with Bontril, and I couldn't be happier. It's worked well for me in conjunction with insulin, and my A1C has improved as a result.

5

Patient Review

11/2/2011

Bontril for Overweight

Bontril was effective for me in helping to lose weight. I saw the most success when taking it every day for the first two months, then every other day for the third month.

5

Patient Review

2/7/2009

Bontril for Overweight

I started this treatment on 9/30/08 and I was 230lbs. Today is 10/7/2008 and I have already lost 7lbs. This is the first thing that has ever worked for me and I am very happy. Remember, this pill is for obesity, not just to lose 10 pounds. My doctor told me I have to use it for 3 months then take a break of 1 month and start again...

5

Patient Review

11/29/2007

Bontril for Overweight

5

Patient Review

8/19/2008

Bontril for Overweight

5

Patient Review

11/29/2007

Bontril for Overweight

5

Patient Review

8/19/2008

Bontril for Overweight

5

Patient Review

6/30/2009

Bontril for Overweight

Bontril is assisting me in my weight loss journey, which I am very appreciative of. The only problem I have experienced thus far is that it makes me feel incredibly irritable. This is likely due to it being a stimulant; as those usually lead to increased anxiety levels. Consequently, I have been feeling more emotional and on-edge. Hopefully, these side effects will dissipate soon enough as the drug itself has been helpful.

5

Patient Review

10/12/2009

Bontril for Overweight

In just two months, I've gone from 247 pounds to 218.

5

Patient Review

5/21/2010

Bontril for Overweight

I've lost 12lbs in 3 weeks thanks to this medication- 49 more to go!

5

Patient Review

10/28/2010

Bontril for Overweight

Bontril has been a key part of my weight-loss journey. I've lost 37 pounds in just 13 weeks, and I couldn't be happier.

3.7

Patient Review

3/19/2009

Bontril for Overweight

The phentermine 37.5 made it hard to work because my heart was racing constantly. So, I called to switch to Bontril and am waiting for that to be more effective. Has anyone else had this problem?

3.7

Patient Review

7/3/2009

Bontril for Overweight

I was disappointed that I didn't see the same rapid weight loss that others reported. Instead, my weight came off slowly. And now, even after stopping use of the medication months ago, I'm still experiencing racing heart, shortness of breath, and anxiety.

3.7

Patient Review

7/3/2009

Bontril for Overweight

I slowly lost weight while taking this medication, but have since gained half of it back. I'm also now experiencing racing heart, shortness of breath, and anxiety - even though I stopped taking the medicine months ago. Overall, not a great experience.

3.7

Patient Review

3/19/2009

Bontril for Overweight

I am currently on phentermine 37.5, but I find it difficult to concentrate at work because my heart rate is always high. I'm going to try Bontril instead and see if that helps. Has anyone else had this problem?

3

Patient Review

12/29/2008

Bontril for Overweight

I didn't feel as ravenous for the first few days, but now I'm back to normal.

3

Patient Review

12/29/2008

Bontril for Overweight

For the first few days, I experienced a decreased appetite. Now, however, my hunger is back to its original state.

2.7

Patient Review

7/6/2010

Bontril for Overweight

I was given this medication to help me lose weight, but it not only failed to do that, it also caused the worst constipation I've ever experienced.

2.7

Patient Review

7/6/2010

Bontril for Overweight

Bontril didn't help me lose any weight, and made me incredibly constipated to the point where I had to go to the ER.

2.7

Patient Review

2/7/2008

Bontril for Overweight

2.7

Patient Review

2/7/2008

Bontril for Overweight

2.7

Patient Review

7/13/2011

Bontril for Overweight

While it didn't help me with appetite or cravings, I appreciate that this treatment exists.

2.7

Patient Review

7/13/2011

Bontril for Overweight

I didn't find it effective in curbing my appetite or cravings.

2

Patient Review

6/19/2013

Bontril for Overweight

I had to stop taking this after just two pills because my vision became very blurry. Even now, a month later, it hasn't fully recovered.

2

Patient Review

6/19/2013

Bontril for Overweight

I had to stop taking this after just two pills because my vision started getting blurry. Even now, about a month later, it hasn't fully recovered.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bontril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Bontril work for weight loss?

"Phendimetrazine is a drug that is used to help people lose weight by reducing their appetite. It is often used in conjunction with a doctor-approved diet and exercise program."

Answered by AI

Is Bontril still available?

"The Bontril Slow Release product has been discontinued and is no longer available in the United States. If the Food and Drug Administration has approved generic versions of this product, there may be generic equivalents available from other manufacturers."

Answered by AI

What does Bontril do?

"This medication is designed to be used alongside a doctor-approved weight loss plan that includes reducing calorie intake and exercising regularly. It works by suppressing appetite."

Answered by AI

What is the difference between Bontril and phentermine?

"Bontril PDM can help you lose weight, but it shouldn't be used for long periods of time and it isn't for everyone. Adipex-P is effective at lowering appetite and helping with weight loss. Available in generic form, which is more affordable. You only need to take it for a short period of time."

Answered by AI