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What is Dyazide
TriamtereneThe Generic name of this drug
Treatment SummaryTriamterene is a medication used to treat high blood pressure. It works by promoting the excretion of sodium and water from the body while helping to retain potassium. High levels of potassium can be dangerous, so triamterene needs to be carefully monitored when prescribed. Triamterene is sometimes used with other diuretics to enhance their effects and can also be found in combination with hydrochlorothiazide for treating edema and hypertension. It was approved by the FDA in 1964 and is generally considered safe and effective.
Maxzideis the brand name
Dyazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxzide
Triamterene
1988
188
Effectiveness
How Dyazide Affects PatientsTriamterene is a medication used to lower blood pressure and reduce swelling. It works in the kidneys by not allowing sodium and magnesium to be reabsorbed, and instead promotes the excretion of potassium. This can lead to an increase in potassium levels that can cause irregular heartbeats. In clinical trials, triamterene was found to be more effective when taken with hydrochlorothiazide in lowering blood pressure. It does not affect calcium excretion.
How Dyazide works in the bodyTriamterene is a diuretic drug that helps reduce sodium absorption in the late distal tubule of the kidney. It works by blocking sodium channels, which limits the amount of sodium that can be reabsorbed into the body. It also helps reduce loss of potassium, hydrogen, and chloride ions. Triamterene increases urine output and decreases sodium, potassium, and magnesium levels in the body.
When to interrupt dosage
The portion of Dyazide is contingent upon the identified disorder, including Cirrhosis, Hypokalemia and Edema. The exact dosage is contingent upon the approach of delivery (e.g. Capsule or Tablet - Oral) described in the table hereunder.Condition
Dosage
Administration
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Thiazides
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypokalemia
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Nephrotic Syndrome
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Swollen feet or ankles
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diuretics
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cirrhosis
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
Dyazide has five contraindications, and thus should not be administered when suffering from the conditions in the following table.Dyazide ContraindicationsCondition
Risk Level
Notes
Renal Insufficiency, Chronic
Do Not Combine
Hyperkalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Liver diseases
Do Not Combine
Common Dyazide Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Neomycin.
Tacrolimus
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Tenofovir
Major
Triamterene may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Triamterene may increase the nephrotoxic activities of Tenofovir alafenamide.
Dyazide Toxicity & Overdose RiskAn overdose of triamterene can be dangerous, causing symptoms such as nausea, vomiting, weakness, and low blood pressure. These symptoms are due to an imbalance of electrolytes, such as an increase of potassium. To treat an overdose, vomiting and stomach pumping should be done right away. Doctors may also monitor electrolyte levels and fluid balance. Dialysis may be able to help remove the drug from the body. Long-term studies in mice suggest that triamterene can cause liver tumors, but it is not known if this is true in humans. Also, triamterene has not been tested to see
Dyazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Dyazide?
138 active studies are currently assessing the effectiveness of Dyazide in managing Cirrhosis, Hypokalemia and Nephrotic Syndrome.Condition
Clinical Trials
Trial Phases
Cirrhosis
51 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1
Edema
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Swollen feet or ankles
6 Actively Recruiting
Phase 2, Not Applicable
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Edema
0 Actively Recruiting
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Edema
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Thiazides
0 Actively Recruiting
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Dyazide Reviews: What are patients saying about Dyazide?
4.7Patient Review
4/23/2018 I've been taking this medication for a few years to help with water retention and it's done a great job. Recently though, I've started experiencing dry mouth and dizziness.
4.7Patient Review
8/25/2017 I use this medication for my blood pressure and I've already noticed some great results. My shortness of breath has decreased, and the swelling in my ankles from amlodipine is gone.
4.7Patient Review
4/23/2018 I've been taking this medication for a while now and it's done wonders in reducing the water retention in my legs and ankles. Recently though, I've started to experience dry mouth and dizziness.
4.7Patient Review
8/25/2017 I use this for my blood pressure and I saw an immediate difference. Not only did my shortness of breath go away, but the swelling in my ankles from amlodipine disappeared as well. I was hesitant to try this treatment at first, but I'm glad I did.
4.3Patient Review
12/23/2016Patient Q&A Section about dyazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the pill Dyazide used for?
"This drug is a combination of two diuretics, triamterene and hydrochlorothiazide, which are used to lower blood pressure to prevent strokes, heart attacks, and kidney problems."
Answered by AI
What are side effects of Dyazide?
"There are a variety of possible side effects that come with this medication, such as nausea, diarrhea, constipation, blurred vision, and a dry mouth. In rarer cases, you may experience a skin rash."
Answered by AI
Is Dyazide a good diuretic?
"Dyazide is a diuretic that is used to treat high blood pressure and swelling. It is a 2-in-1 diuretic that combines hydrochlorothiazide and triamterene. It is helpful for people who need to take hydrochlorothiazide and have low potassium levels."
Answered by AI
What class of drug is Dyazide?
"Dyazide is a type of diuretic drug which works by causing the kidneys to get rid of sodium and water while holding on to potassium."
Answered by AI