Diflunisal

Pain, Rheumatoid Arthritis, Osteoarthritis + 1 more
Treatment
5 FDA approvals
20 Active Studies for Diflunisal

What is Diflunisal

DiflunisalThe Generic name of this drug
Treatment SummaryDiflunisal is a type of nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by blocking the production of substances that cause inflammation in the body. Diflunisal is commonly used to reduce pain and swelling associated with rheumatoid arthritis and osteoarthritis.
Diflunisalis the brand name
image of different drug pills on a surface
Diflunisal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diflunisal
Diflunisal
1992
17

Approved as Treatment by the FDA

Diflunisal, also known as Diflunisal, is approved by the FDA for 5 uses which include Osteoarthritis (OA) and Rheumatoid Arthritis .
Osteoarthritis (OA)
Rheumatoid Arthritis
Pain
Mild pain
Osteoarthritis

Effectiveness

How Diflunisal Affects PatientsDiflunisal is a non-narcotic painkiller, anti-inflammatory, and fever reducer. It is not known to cause addiction or tolerance. The chemical makeup of diflunisal is different from aspirin, as it has two fluorine atoms in the difluorophenyl ring structure instead of an acetyl group. It does not break down into salicylic acid, so it works differently than aspirin.
How Diflunisal works in the bodyWe don't know exactly how diflunisal works, but it likely reduces the amount of pain-causing chemicals in the body. These chemicals, called prostaglandins, can increase sensitivity to pain and inflammation. By reducing their amount in the body, diflunisal helps to reduce pain and inflammation.

When to interrupt dosage

The endorsed dosage of Diflunisal is contingent upon the diagnosed condition, including Rheumatoid Arthritis, Mild Pain and Pain. The measure of dosage varies as per the approach of application (e.g. Tablet - Oral or Oral) featured in the table beneath.
Condition
Dosage
Administration
Mild pain
500.0 mg, , 250.0 mg
Tablet, film coated, , Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet
Pain
500.0 mg, , 250.0 mg
Tablet, film coated, , Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet
Rheumatoid Arthritis
500.0 mg, , 250.0 mg
Tablet, film coated, , Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet
Osteoarthritis
500.0 mg, , 250.0 mg
Tablet, film coated, , Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet

Warnings

There are 20 known major drug interactions with Diflunisal.
Common Diflunisal Drug Interactions
Drug Name
Risk Level
Description
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Diflunisal.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Diflunisal.
Mycophenolic acid
Major
The metabolism of Mycophenolic acid can be decreased when combined with Diflunisal.
Diflunisal Toxicity & Overdose RiskThe toxic dose of diflunisal in rats, mice, and rabbits is 392mg/kg, 439mg/kg, and 603mg/kg respectively. Symptoms of an overdose include drowsiness, nausea, vomiting, diarrhea, rapid breathing, rapid heartbeat, sweating, ringing in the ears, confusion, stupor, and coma. Taking 15 grams of diflunisal at one time has been linked to death. There is a risk of cardiovascular events such as heart attack and stroke, especially with long-term use. Short-term use may increase the risk of gastrointestinal problems, kidney damage, liver
image of a doctor in a lab doing drug, clinical research

Diflunisal Novel Uses: Which Conditions Have a Clinical Trial Featuring Diflunisal?

75 active trials are currently underway to determine the potential of Diflunisal to alleviate Osteoarthritis (OA), Mild Pain and Rheumatoid Arthritis.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
55 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Mild pain
0 Actively Recruiting

Diflunisal Reviews: What are patients saying about Diflunisal?

5Patient Review
11/22/2008
Diflunisal for Rheumatoid Arthritis
This drug was prescribed a week ago for an abcessed tooth and associated swelling. It worked very quickly to eliminate the pain overnight. The script was for 20 pills, but I'll stop taking it today. The associated benefits were relief from arthritis and fibromyalgia pain.
5Patient Review
4/23/2011
Diflunisal for Joint Damage causing Pain and Loss of Function
Within a week, I had experienced several complications including rectal bleeding, intense stomach pain, and crippling headaches. Almost all of the potential side effects listed on the medication's website applied to me.
5Patient Review
11/22/2008
Diflunisal for Pain
Unfortunately, this medication didn't do much for me in terms of pain relief or reducing inflammation. I found that a couple ibuprofren did a better job.
5Patient Review
9/30/2013
Diflunisal for Pain
This has been a life-saver for me. I'm unable to take hydrocodone, and this stops the pain just as effectively.
4.7Patient Review
8/28/2013
Diflunisal for Chronic Pain
Diflunisal has been a game-changer for me. I was diagnosed with Fibromyalgia & Chronic Myofascial Pain in 2002 and have been taking Tramadol & Cymbalta since then. The meds stopped working and I felt "radiating" pain all over my body. Diflunisal 500mg 3 x a day has helped to diminish the "radiating" pain and I am able to do more now.
4.3Patient Review
9/14/2009
Diflunisal for Arthritis
I have fibromyalgia, rheumatoid arthritis, polymyalgia, chronic mylemonocytic leukemia, incontinence and pain all over. Diflunisal works well for me in combination with Robaxin (a muscle relaxer). I see a significant difference in as little as 30 minutes. This is great because I also experience severe muscle spasms in my lower back. Additionally, it doesn't seem to bother my stomach like some other treatments do.
4.3Patient Review
6/20/2013
Diflunisal for Chronic Pain
I've been taking this for a while now with excellent results and no side effects.
4Patient Review
5/30/2013
Diflunisal for Arthritis
I've only just started taking this medication for my chronic neck pain, so it's hard to give a thorough review. So far, though, I'm cautiously optimistic.
3.7Patient Review
12/27/2012
Diflunisal for Arthritis
I've tried a lot of different medications for my arthritis, and this one is by far the most effective. It takes a few days to really kick in, but it's worth the wait.
3.3Patient Review
8/23/2011
Diflunisal for Chronic Pain
Nausea, vomiting, headaches, and fatigue have been my experience with this medication. So far it hasn't done anything to help ease the pain of my arthritis. I'm going to give it a few more days, but if things don't improve I'll be looking for something else.
3.3Patient Review
11/3/2012
Diflunisal for Arthritis
Overall, this was working great for me and I was able to walk normally again. However, it took a few days to realize that the worst outbreak of canker sores I ever had was a side effect. The same thing happened with the replacement pain killer!
3.3Patient Review
6/8/2008
Diflunisal for Chronic Pain
2.7Patient Review
1/29/2011
Diflunisal for Arthritis
I've been using this treatment for my arthritis for about three months now, and it's done a pretty good job of alleviating the symptoms.
1Patient Review
3/12/2018
Diflunisal for Pain
This medicine made me nauseous, even when I took it with food.
1Patient Review
11/4/2009
Diflunisal for Arthritis
I would not recommend this medication because it causes unexpected bleeding.
1Patient Review
12/9/2008
Diflunisal for Chronic Pain
Diflunisal is effective for treating my tendonitis and the inflammation in my hip. I don't experience any stomach upset because I take it after eating.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about diflunisal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is diflunisal an opioid?

"Dolobid is a medication that helps with pain, inflammation, and fever. It is non-narcotic and does not cause addiction, tolerance, or habituation."

Answered by AI

What are diflunisal used for?

"Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) that can be used to treat mild to moderate pain, and provides relief from arthritis symptoms (e.g. osteoarthritis and rheumatoid arthritis), including inflammation, swelling, stiffness, and joint pain."

Answered by AI

What class drug is diflunisal?

"Diflunisal is an NSAID, a medication that works by stopping the body's production of a substance that causes pain, fever, and inflammation."

Answered by AI

How long does it take for diflunisal to work?

"If you have an ongoing condition such as arthritis, keep taking the medication as prescribed by your doctor. Talk to your doctor or pharmacist about the risks and benefits of taking this drug. It may take a few weeks of regular use before you feel the full effects of the medication if you have a condition such as arthritis."

Answered by AI

Clinical Trials for Diflunisal

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.
Phase 4
Waitlist Available
Sunnybrook Health Sciences Centre (+4 Sites)
Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Have you considered Diflunisal clinical trials? We made a collection of clinical trials featuring Diflunisal, we think they might fit your search criteria.Go to Trials
Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesDaniel ZachsSecondWave Systems Inc.
Have you considered Diflunisal clinical trials? We made a collection of clinical trials featuring Diflunisal, we think they might fit your search criteria.Go to Trials
Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Image of Pender Community Health Centre in Vancouver, Canada.

Personalized Outreach for Rheumatic Diseases

18+
All Sexes
Vancouver, Canada
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia. The main question it aims to answer are: * Does providing a financial honorarium ($20 for each follow-up appointment with completed bloodwork) improve attendance rate at an inner city rheumatology clinic? * Does providing a personalized outreach service for rheumatic diseases improve attendance rate at an inner city rheumatology clinic? The researchers will compare providing patient honoraria to providing both honoraria and outreach services, and compare each of these to the regular appointment schedule without honoraria or outreach. Participants will: * Undergo randomization to receive honoraria or honoraria and outreach services together * Complete surveys about their health and understanding of their rheumatic disease at baseline, 3-month, and 6-month intervals * Visit the clinic every month for check-ups and monitoring bloodwork if they are started on immunosuppressants for their condition
Waitlist Available
Has No Placebo
Pender Community Health CentreBrent R Ohata, MD
Image of Clinical Research Of West Florida - Phase I Unit /ID# 272428 in Clearwater, United States.

Targeted Therapies for Rheumatoid Arthritis

18+
All Sexes
Clearwater, FL
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Clinical Research Of West Florida - Phase I Unit /ID# 272428 (+32 Sites)ABBVIE INC.AbbVie
Have you considered Diflunisal clinical trials? We made a collection of clinical trials featuring Diflunisal, we think they might fit your search criteria.Go to Trials
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