Dorzolamide Hydrochloride

prophylaxis of elevated intraocular pressure, neodynium yttrium aluminum garnet laser posterior capsulotomy, Glaucoma + 3 more

Treatment

7 FDA approvals

18 Active Studies for Dorzolamide Hydrochloride

What is Dorzolamide Hydrochloride

Dorzolamide

The Generic name of this drug

Treatment Summary

Dorzolamide is a medication used to treat high pressure in the eyes caused by open-angle glaucoma and ocular hypertension. It works by blocking an enzyme in the eye that helps control fluid pressure. It has minimal side effects compared to other medications and was first introduced in 1995 under the brand name Trusopt or Cosopt PF.

Trusopt

is the brand name

image of different drug pills on a surface

Dorzolamide Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Trusopt

Dorzolamide

1994

62

Approved as Treatment by the FDA

Dorzolamide, also known as Trusopt, is approved by the FDA for 7 uses such as Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma (OAG) .

Increased Intra Ocular Pressure (IOP)

Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol

Open Angle Glaucoma (OAG)

Used to treat Open Angle Glaucoma (OAG) in combination with Timolol

insufficient response to beta-blockers

Used to treat insufficient response to beta-blockers in combination with Timolol

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Timolol

Glaucoma

Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Timolol

Open Angle Glaucoma

Used to treat Open Angle Glaucoma (OAG) in combination with Timolol

Effectiveness

How Dorzolamide Hydrochloride Affects Patients

Dorzolamide is a medication that helps to lower high eye pressure caused by open-angle glaucoma or ocular hypertension. It can be used with other medications, like beta-blockers, to further reduce eye pressure. The effects of this drug usually peak after two hours after it is given.

How Dorzolamide Hydrochloride works in the body

Dorzolamide is used to treat ocular hypertension and open-angle glaucoma, which cause increased pressure in the eye. This increased pressure can lead to damage of the optic nerve, resulting in vision loss. Dorzolamide works by decreasing aqueous humour (fluid) production in the eye and reducing pressure. It does this by targeting an enzyme called carbonic anhydrase (CA), which helps regulate fluid production. Dorzolamide specifically targets CA-II, an enzyme found in red blood cells, and blocks its effects. This reduces the formation of bicarbonate ions and decreases sodium and fluid

When to interrupt dosage

The indicated dose of Dorzolamide Hydrochloride is reliant upon the determined situation, for example neodynium yttrium aluminum garnet laser posterior capsulotomy, Ocular Hypertension and Increased Intra Ocular Pressure (IOP). The quantity of dosage is contingent upon the administration approach (e.g. Solution - Ophthalmic or Solution / drops) stated in the table beneath.

Condition

Dosage

Administration

prophylaxis of elevated intraocular pressure

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

neodynium yttrium aluminum garnet laser posterior capsulotomy

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

Glaucoma

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

Open Angle Glaucoma

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

Ocular Hypertension

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

insufficient response to beta-blockers

20.0 mg/mL, , 22.3 mg/mL, 2.0 %

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic

Warnings

Dorzolamide Hydrochloride Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Dorzolamide may interact with Pulse Frequency

There are 20 known major drug interactions with Dorzolamide Hydrochloride.

Common Dorzolamide Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Acebutolol

Minor

Dorzolamide may increase the hypotensive activities of Acebutolol.

Acetylsalicylic acid

Minor

The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Acetylsalicylic acid.

Aliskiren

Minor

Dorzolamide may increase the hypotensive activities of Aliskiren.

Aloxiprin

Minor

The risk or severity of metabolic acidosis can be increased when Dorzolamide is combined with Aloxiprin.

Ambrisentan

Minor

Dorzolamide may increase the hypotensive activities of Ambrisentan.

Dorzolamide Hydrochloride Toxicity & Overdose Risk

The toxic dose of dorzolamide in rats is 1927 mg/kg and 1320 mg/kg in mice. If someone takes too much, they may have an electrolyte imbalance, acidosis, or effects on their central nervous system. If this happens, electrolyte levels and blood pH should be monitored and appropriate supportive treatment should be given.

image of a doctor in a lab doing drug, clinical research

Dorzolamide Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Dorzolamide Hydrochloride?

34 active trials are currently evaluating the efficacy of Dorzolamide Hydrochloride in treating Ocular Hypertension, Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma.

Condition

Clinical Trials

Trial Phases

Glaucoma

0 Actively Recruiting

Ocular Hypertension

10 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

insufficient response to beta-blockers

0 Actively Recruiting

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

prophylaxis of elevated intraocular pressure

0 Actively Recruiting

neodynium yttrium aluminum garnet laser posterior capsulotomy

0 Actively Recruiting

Dorzolamide Hydrochloride Reviews: What are patients saying about Dorzolamide Hydrochloride?

5

Patient Review

3/14/2018

Dorzolamide Hydrochloride for Increased Pressure in the Eye

My vision improved significantly and immediately.

4.7

Patient Review

6/23/2010

Dorzolamide Hydrochloride for Increased Pressure in the Eye

I've used this for years and it has saved my vision.

4.3

Patient Review

6/30/2011

Dorzolamide Hydrochloride for Increased Pressure in the Eye

Though this product has improved the pressure in my eye, I am now constantly tired which I believe is a side effect. As I am already blind in that eye, I am discussing with my doctor whether to stop taking it or decrease my dosage.

3.7

Patient Review

9/27/2009

Dorzolamide Hydrochloride for Wide-Angle Glaucoma

Along with two other treatments, I use this for my glaucoma. Though it was effective in reducing pressure in the eye, I found that it caused hoarseness and weakness in my vocals. Additionally, I often experienced achy pain in the treated eye.

3

Patient Review

2/8/2014

Dorzolamide Hydrochloride for Increased Pressure in the Eye

I find this drug makes me incredibly tired, to the point where I have almost fallen asleep at the wheel. I also get more headaches and my sinuses are always bothering me since using it. The nasel secretions are very thick and sticky-stringy like paste. I get severe eye pain that is only relieved with a narcotic! & it barely reduces the interoccular pressure.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dorzolamide hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When should dorzolamide be taken?

"For adults, use one drop in the affected eye two times a day. For children 2 years of age or older, the dose must be determined by a doctor."

Answered by AI

What are the side effects for dorzolamide?

"You may experience some temporary side effects such as blurred vision, burning or stinging sensations in the eyes, watery eyes, dry eyes, increased sensitivity to light, a bitter taste, or a headache."

Answered by AI

How long can I use dorzolamide eye drops?

"You should only use eye drops that have been opened for four weeks or less to help prevent the risk of eye infections. Single-dose units should be used immediately after they are opened."

Answered by AI

What is Dorzolamide Hydrochloride used for?

"Dorzolamide ophthalmic drops are used to treat increased pressure in the eye caused by open-angle glaucoma or hypertension of the eye. Both conditions are caused by high pressure in your eye and can lead to pain and eventual harm to your vision."

Answered by AI

Clinical Trials for Dorzolamide Hydrochloride

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We made a collection of clinical trials featuring Dorzolamide Hydrochloride, we think they might fit your search criteria.
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Have you considered Dorzolamide Hydrochloride clinical trials?

We made a collection of clinical trials featuring Dorzolamide Hydrochloride, we think they might fit your search criteria.
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Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

Have you considered Dorzolamide Hydrochloride clinical trials?

We made a collection of clinical trials featuring Dorzolamide Hydrochloride, we think they might fit your search criteria.
Go to Trials