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What is Adapalene
AdapaleneThe Generic name of this drug
Treatment SummaryAcne vulgaris is a skin condition caused by an increase in sebum, inflammation, and changes to the follicles. Adapalene is a topical retinoid used to treat acne vulgaris. It is effective and safe compared to other medications, such as tretinoin, and can be combined with benzoyl peroxide for even better results. The brand name Differin was approved by the FDA in 1996 and is available as a 0.1% topical solution, gel, cream, or lotion, or 0.3% gel products. Epiduo, a combination of adapalene and benz
Adapaleneis the brand name
Adapalene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Adapalene
Adapalene
1996
71
Effectiveness
How Adapalene Affects PatientsAdapalene can help stop new comedones (acne) and inflammation from forming. It works similarly to other retinoid compounds, but should be used with sunscreen, as it can be affected by sunlight. Some people may experience minor skin irritation such as redness, flaking, dryness, and stinging or burning.
How Adapalene works in the bodyAdapalene works to treat and maintain mild to severe acne. It does this by binding to proteins in the skin's cells that help regulate cell growth and differentiation. This helps reduce the number of blocked pores and comedones. Adapalene also works to reduce inflammation caused by the bacteria that are often associated with acne. When combined with benzoyl peroxide, the two agents work together to reduce inflammation and comedones.
When to interrupt dosage
The proposed measure of Adapalene is contingent upon the determined condition. The amount of dosage likewise alters as per the mode of delivery (e.g. Topical or Gel) demonstrated in the table beneath.Condition
Dosage
Administration
Acne Vulgaris
0.001 mg/mg, , 0.003 mg/mg, 1.0 mg/mL, 0.1 %, 0.3 %, 45.0 mg/mg, 1.5 mg/mg
, Topical, Cream - Topical, Cream, Gel, Gel - Topical, Lotion, Lotion - Topical, Swab, Swab - Topical, Liquid - Topical, Liquid, Solution, Solution - Topical, Kit
Warnings
Adapalene ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Adapalene may interact with Pulse Frequency
Common Adapalene Drug Interactions
Drug Name
Risk Level
Description
Adapalene Toxicity & Overdose RiskAdapalene is generally considered safe, however, an overdose may cause redness, scaling, and skin discomfort. In animal studies, the highest dose of adapalene that did not cause any adverse effects was 5000mg/kg for rats and mice and 30mg/kg for mice when applied topically.
Adapalene Novel Uses: Which Conditions Have a Clinical Trial Featuring Adapalene?
Condition
Clinical Trials
Trial Phases
Acne Vulgaris
8 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Adapalene Reviews: What are patients saying about Adapalene?
5Patient Review
11/20/2015 I've been using this for about five weeks now, and my skin is finally clearing up. At first, I actually broke out more as everything was coming to the surface; but it's worth it in the long run. Another benefit is that it's also helping to fade some of my sun spots!
5Patient Review
9/30/2020 Adapalene has been working great for me for the last five years. It's worth noting that, when you first start using it, your acne might get worse before it gets better. In my experience, preventing excessive dryness and irritation is a matter of washing your face, waiting 20 minutes or so, applying the product, waiting another 20 minutes, then washing it off and applying moisturizer while your skin is still damp.
5Patient Review
9/14/2017 This medication is amazing! It's helped both my daughter and myself.
5Patient Review
10/4/2016 I didn't see results for about a week after I started using this product, but it was well worth the wait. My skin completely cleared up and now looks healthy and vibrant.
4.3Patient Review
1/30/2018 I was surprised to find myself still dealing with acne in my forties, but this medication has been a huge help. After just two weeks of consistent use, my skin is almost entirely clear. I would definitely recommend this product to others!
4.3Patient Review
8/5/2021 Acne gets worse before it gets better. Scaling , peeling and dryness are my side effects. I have "maskney" since I'm in the medical field, I have to wear a mask....and wearing it all day gives me pimples :(
3.7Patient Review
5/31/2016 I've had mixed results with this medication. Sometimes it works great and other times I feel like a total hermit. The acne got worse when I first started taking it, but that may just be part of the process.
3Patient Review
2/8/2015 After using this product for a little over a month, my skin is five times worse than when I started. I'm not sure if that's because it's supposed to clean out your pores or if the product just doesn't work for me, but either way it sucks. My acne scars have gotten worse and I've been breaking out more.
3Patient Review
2/25/2022 My face is in a lot of pain.
3Patient Review
6/27/2017 I used this medication for acne treatment for over a year, but recently stopped because my face became very irritated. The redness was constant and difficult to cover with makeup. Additionally, I didn't feel like the product was working very well for me.
2.7Patient Review
11/29/2014 I was given this medication for my cystic acne, but after reading that it can take months for your skin to get used to it, I've decided not to bother. It's caused me nothing but more problems.
2.7Patient Review
4/26/2019 I found that this product drying my skin out to an excessive degree, to the point where it was uncomfortable for over two weeks every time I used it.
1.7Patient Review
10/3/2016 I've been using Adaplene for a few weeks now, but my acne seems to be getting worse. I'm really hoping this treatment will help me clear up my skin, as I've been dealing with acne for twelve years now.
1Patient Review
3/2/2020 DO NOT USE THIS PRODUCT. I ended up with a chemical burn that made my face red, swollen, and burning. It's been two days and I still can't put anything on my face except for cold washcloths. So disappointed, would not recommend to anyone.
Patient Q&A Section about adapalene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does adapalene do for skin?
"Adapalene is a medication used to treat acne. It works by preventing pimples from forming under the surface of the skin."
Answered by AI
Does adapalene Gel remove dark spots?
"Adapalene is a retinoid drug derived from vitamin A, and is approved by the FDA for treating acne. It can also be used to lighten dark spots, lessen wrinkles and fine lines, and treat actinic keratoses and other skin conditions."
Answered by AI
What are the side effects of adapalene?
"The side effects of the medication usually go away after a few weeks of taking it, but some skin conditions may get worse before they get better. If you experience any of these side effects, talk to your doctor or pharmacist."
Answered by AI
Is adapalene the same as retinol?
"Are Retinol and Adapalene the Same Thing? Both retinol and adapalene are retinoids, but they are not the same thing. Retinol is like broccoli and adapalene is like cauliflower--both are vegetables with florets but one isn't the other. Adapalene is stronger and more potent than retinol because it contains active retinoic acid."
Answered by AI