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What is Hydrodiuril
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a commonly prescribed medication used to treat swelling and high blood pressure. Although it is still used, it is becoming less popular as angiotensin converting enzyme inhibitors and angiotensin II receptor blockers become more popular options. There are multiple combination products available that contain hydrochlorothiazide and either an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker. Hydrochlorothiazide was approved by the FDA in 1959.
Esidrixis the brand name
Hydrodiuril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 30 uses including Congestive Heart Failure (CHF) and Hypertension .Congestive Heart Failure (CHF)
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertension
Used to treat Antihypertensive Treatment in combination with Eprosartan
Edema
Used to treat Edema in combination with Triamterene
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Cirrhosis of the Liver
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypertension
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Hypertrophy, Left Ventricular
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertension, Essential Hypertension
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Hypertension
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
prophylaxis of preeclampsia
Helps manage prophylaxis of preeclampsia
Ascites
Used to treat Ascites in combination with Spironolactone
Premenstrual tension with edema
Helps manage Premenstrual tension with edema
Hypokalemia
Used to treat hypokalemia with solo treatment in combination with Triamterene
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Effectiveness
How Hydrodiuril Affects PatientsHydrochlorothiazide helps your body remove more water by blocking the reabsorption of sodium and water from the distal convoluted tubule. This drug can be taken in doses ranging from 25-100mg, depending on the patient's individual needs. People with reduced kidney or liver function should use this drug with caution.
How Hydrodiuril works in the bodyHydrochlorothiazide helps lower blood pressure by blocking sodium reabsorption in the kidneys. It does this by binding to an organic anion transporter, which carries it into kidney cells. There, it binds to a protein that helps transport it into the lumen of the tubule. Hydrochlorothiazide then blocks a molecule that helps move sodium and chloride into kidney cells, reducing the concentration difference between them and the tubule, which reduces water reabsorption.
When to interrupt dosage
The proposed dose of Hydrodiuril is contingent upon the determined disorder, including Antepartum magnesium sulfate prophylaxis, inadequate blood pressure control with monotherapy and antihypertensives. The quantity of dosage is contingent upon the approach of administration (e.g. Tablet, coated - Oral or Oral) as expressed in the subsequent table.Condition
Dosage
Administration
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Swollen feet or ankles
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertrophy, Left Ventricular
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Hydrodiuril ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Hydrodiuril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Hydrodiuril Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Symptoms of an overdose may include low levels of potassium, chlorine, or sodium in the blood. Treatment for an overdose should involve supportive care such as fluids and electrolytes, as well as specific treatments such as vasopressors to treat low blood pressure and oxygen for respiratory issues.
Hydrodiuril Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydrodiuril?
158 active clinical trials are being conducted to appraise the efficacy of Hydrodiuril in mitigating conditions such as Cirrhosis, Oedema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Sodium retention
0 Actively Recruiting
Diuretics
0 Actively Recruiting
restriction of fluid and sodium
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Hypertrophy, Left Ventricular
0 Actively Recruiting
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
prophylaxis of calcium nephrolithiasis
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
19 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Congestive Heart Failure
13 Actively Recruiting
Not Applicable, Phase 1, Phase 2
calcium channel blockers
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Diabetes Insipidus
1 Actively Recruiting
Phase 2
Renal tubular acidosis
0 Actively Recruiting
Hydrodiuril Reviews: What are patients saying about Hydrodiuril?
5Patient Review
7/15/20102.7Patient Review
4/8/2013 I began taking this medication and have since then developed a cough that just won't go away. I'm concerned that the drug might be the culprit.
2.3Patient Review
1/23/2015 Long-term use of this medication has led to an aggravation of my cough, as well as urination problems.
2.3Patient Review
6/13/2014 Since taking this medication, I have developed a hacking cough that just won't go away. Additionally, I've been having to use the restroom more frequently than usual, which is incredibly inconvenient.
Patient Q&A Section about hydrodiuril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of HydroDIURIL?
"You may experience muscle weakness, dizziness, cramps, constipation, thirst, stomach pain, nausea, or vomiting."
Answered by AI
Is hydrochlorothiazide and HydroDIURIL the same?
"Water pills like hydrochlorothiazide are used to treat high blood pressure and edema by helping the body get rid of excess water and salt. Hydrochlorothiazide is sold as a generic drug and also under the brand names Microzide, HydroDiuril, and Oretic."
Answered by AI
What should you avoid when taking hydrochlorothiazide?
"If you take barbiturates with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take lithium with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take blood pressure drugs with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take cholesterol-lowering drugs with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take corticosteroids with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take diabetes drugs with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take narcotics with hydrochlorothiazide, your blood pressure may be lowered too much.
If you take nonsteroidal anti-inflammatory drugs (NSAIDs) with hydrochlorothiazide, your blood pressure may be lowered too much."
Answered by AI
What is HydroDIURIL used for?
"This helps your body get rid of extra salt and water.
This medication lowers blood pressure by causing the body to get rid of extra salt and water through urine."
Answered by AI