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N Acetylcysteine for Cognitive Impairment
Phase 2
Waitlist Available
Led By Krista L Lanctôt, PhD
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Summary
This trial tests if taking an NAC supplement can help improve brain function in patients with mild cognitive issues who are also in a heart rehab program. NAC works by protecting brain cells from damage. N-acetylcysteine (NAC) has been studied for its potential benefits in various conditions, including brain injury, cognitive impairment, and oxidative stress.
Eligible Conditions
- Vascular dementia
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in executive function
Secondary study objectives
Change in memory
Change in processing speed
Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: N-acetylcysteineActive Control1 Intervention
Participants randomized into the N-acetylcysteine arm will be receiving N-acetylcysteine for 24 weeks.
Group II: PlaceboPlacebo Group1 Intervention
Participants randomized into the placebo arm will be receiving placebo for 24 weeks.
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Who is running the clinical trial?
Sunnybrook Health Sciences CentreLead Sponsor
674 Previous Clinical Trials
1,565,795 Total Patients Enrolled
Krista L Lanctôt, PhDPrincipal InvestigatorSunnybrook Research Institute
2 Previous Clinical Trials
25,015 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have had a stroke in the past.You have extremely high or low blood pressure, as determined by a doctor.You have a current neurological condition such as Parkinson's disease, multiple sclerosis, or significant traumatic brain injury.You have severe liver, kidney, or lung problems, or have been diagnosed with HIV, HBV, or HCV infections, or have a history of cancer.You have a past of seizures or epilepsy.You have a severe mental health condition such as depression, schizophrenia, bipolar disorder, or substance abuse issues (e.g. heavy alcohol or cigarette use).You have asthma that is not under control and has required hospitalization or emergency room visits in the past 3 months, according to what you tell us.You use Nitroglycerin on a daily basis.You are allergic to NAC or lactose.
Research Study Groups:
This trial has the following groups:- Group 1: N-acetylcysteine
- Group 2: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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