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What is Kapvay
ClonidineThe Generic name of this drug
Treatment SummaryClonidine is a medication used to treat high blood pressure, severe pain, and Attention Deficit Hyperactivity Disorder (ADHD). It works by activating alpha-2 adrenoceptors in the body. Clonidine was approved by the FDA in 1974 and has been commonly prescribed ever since.
Catapresis the brand name
Kapvay Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Catapres
Clonidine
1974
447
Effectiveness
How Kapvay Affects PatientsClonidine works by activating certain receptors in the body, which can reduce blood pressure, make you sleepy, and decrease electrical activity in the nerves. The amount of clonidine needed for it to be effective varies from person to person, and it is typically taken twice a day. The usual recommended dose is between 0.1mg to 2.4mg daily.
How Kapvay works in the bodyClonidine works by binding to the Alpha-2 adrenoceptor, a G-protein found in the brain. This binding causes a change in the G-protein's structure, allowing it to interact with an effector. This process can cause decreased blood pressure, inhibited pain signals, and increased sleepiness. It can also affect regulators of blood pressure in certain areas of the brain.
When to interrupt dosage
The advised measure of Kapvay is contingent upon the diagnosed condition, including methadone, diabetic diarrhea and Hypertensive disease. The dosage fluctuates as per the administration technique (e.g. Oral or Tablet) provided in the table below.Condition
Dosage
Administration
Disease
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Pheochromocytoma
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Hypertensive disease
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Tourette Syndrome
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Attention Deficit and Disruptive Behavior Disorders
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Smoke
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
clonidine suppression test
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
clozapine
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
methadone
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Cancer Pain
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
growth hormone stimulation test
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
diabetic diarrhea
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Hot flashes
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Neuralgia, Postherpetic
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Human Growth Hormone Deficiency
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Attention Deficit Hyperactivity Disorder
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Smoking Cessation
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Hot Flashes
, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release, For suspension, extended release - Oral, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release, Suspension, extended release - Oral
Warnings
Kapvay has five contraindications. It should not be consumed when experiencing any of the conditions enumerated in the following table.Kapvay ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
administration above the C4 dermatome
Do Not Combine
Communicable Diseases
Do Not Combine
bleeding diathesis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Clonidine may interact with Pulse Frequency
Common Kapvay Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The risk or severity of sedation can be increased when Clonidine is combined with 1,2-Benzodiazepine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The risk or severity of sedation can be increased when Clonidine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The risk or severity of sedation can be increased when Clonidine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
Major
The risk or severity of sedation can be increased when Clonidine is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The risk or severity of sedation can be increased when Clonidine is combined with 5-methoxy-N,N-dimethyltryptamine.
Kapvay Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is 126mg/kg. For humans, the lowest toxic dose is 70µg/kg in children, 126µg/kg in women, and 69µg/kg in men. Symptoms of overdose include high or low blood pressure, slow heartbeat, shallow breathing, hypothermia, drowsiness, decreased reflexes, weakness, irritability, and pupil constriction. In severe cases, patients may experience cardiac problems, difficulty breathing, coma, or seizures. It is not recommended to induce vomiting, but gastric lavage or activated charcoal may be helpful if the
Kapvay Novel Uses: Which Conditions Have a Clinical Trial Featuring Kapvay?
231 active trials are being conducted to investigate the potential of Kapvay in aiding Smoking Cessation, managing Menopause symptoms and alleviating severe Cancer pain.Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
62 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Smoking Cessation
97 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3
clonidine suppression test
0 Actively Recruiting
growth hormone stimulation test
0 Actively Recruiting
diabetic diarrhea
0 Actively Recruiting
Tourette Syndrome
14 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Neuralgia, Postherpetic
1 Actively Recruiting
Not Applicable
Human Growth Hormone Deficiency
4 Actively Recruiting
Phase 4, Phase 2
Cancer Pain
0 Actively Recruiting
Hot Flashes
8 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Disease
9 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
methadone
0 Actively Recruiting
Attention Deficit and Disruptive Behavior Disorders
5 Actively Recruiting
Not Applicable
clozapine
0 Actively Recruiting
Hot flashes
15 Actively Recruiting
Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 4
Pheochromocytoma
0 Actively Recruiting
Smoke
0 Actively Recruiting
Kapvay Reviews: What are patients saying about Kapvay?
5Patient Review
11/19/2011 This treatment has been great for my daughter. She's four years old and was diagnosed with ADHD, so she takes Kapvay and risperidone twice a day. They both work well and help her stay focused and calm throughout the day. It was hard to get her to take the pills at first, but after a while she was able to do it on her own and even tells me when it is time to take them.
5Patient Review
1/12/2012 This drug has been a game-changer for my five-year-old. She's been sleeping through the night since we started using it six months ago.
3.7Patient Review
11/14/2012 My son is 12 years old. He is Autistic, ODD, ADHD and Bi-polar. This medication was suppose to treat the impulsive rage that he has. It helped at first, but after the second week, it stopped working. My doctor just decided to change drugs due to how intense my son's 'freak out' moments were getting. The drug did work very well at first-- for a full two days we had NO drama!!! That was a welcomed blessing from above!
3Patient Review
7/17/2012 My daughter didn't seem to concentrate or focus any better on this medication, and it was quite expensive to maintain the prescribed dosage. She did have fewer upper respiratory infections, however.
2.3Patient Review
5/28/2013 If your child has accidentally taken a double dose of this medication, it's important to seek professional medical advice right away.
Patient Q&A Section about kapvay
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Kapvay prescribed for?
"This drug is used to treat ADHD by itself or with other drugs as part of a comprehensive treatment plan that also includes psychological and social therapies, among other treatments."
Answered by AI
Is Kapvay the same as clonidine?
"Both Kapvay and Catapres contain the drug clonidine. The doses of the two drugs are usually similar. However, Kapvay is used to treat ADHD, while Catapres is used to treat high blood pressure. Catapres is available as an immediate-release tablet, while Kapvay is available as an extended-release tablet."
Answered by AI
How does Kapvay work for ADHD?
"The drug Kapvay works by targeting alpha-2 receptors in the brain in order to potentially reduce symptoms of hyperactivity by altering the way the brain processes emotions, attention, and behavior. While the method by which this drug treats ADHD is not known for certain, the FDA approved its use for pediatric patients aged 6-17 in September of 2010."
Answered by AI
Is Kapvay a stimulant?
"Kapvay is a prescription medicine that is used to treat attention deficit hyperactivity disorder (ADHD). It is supplied as an extended-release tablet. Your doctor may prescribe Kapvay alone or together with other ADHD medicines. Kapvay is not a central nervous system (CNS) stimulant."
Answered by AI